Opioid use disorder is a chronic disease characterized by a maladaptive pattern of opioid use despite negative consequences. In the US, nearly 75 000 overdose deaths occurred in 2023, a 10-fold increase from 1999.1 However, only 1 in 4 US adults eligible for MOUD received it in 2022.2 The 2024...
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Intranasal Treatments for Children With Sleep-Disordered Breathing: The MIST+ Randomized Clinical Trial
Importance: Symptoms of obstructive sleep apnea are common in childhood and associated with significant comorbidity. Surgical treatment with adenotonsillectomy is first-line treatment but medical treatments show potential to improve symptoms and reduce the need for surgery.
Objective: To...
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The Role of Vaccination in Maternal and Perinatal Outcomes Associated With COVID-19 in Pregnancy
Importance: Gaps in knowledge exist about the impact of COVID-19 and vaccination on pregnancy outcomes.
Objective: To investigate the impact of vaccination on maternal and perinatal outcomes associated with SARS-CoV-2 infection in pregnancy.
Design, setting, and population:...
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What Is Prostatitis?
Prostatitis involves infection, inflammation, or pain in the prostate gland and affects about 9% of men during their lifetime.
What Is Acute Bacterial Prostatitis?
Acute bacterial prostatitis is a urinary tract infection that involves the prostate.1 Patients with acute prostatitis...
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Stillbirth
Stillbirth, defined as fetal death at 20 or more weeks of gestation or 350 g or greater in birth weight, is a tragic outcome for families and clinicians.1 Stillbirth affects approximately 5.7 per 1000 births in the US—equivalent to 21 000 annually—and can occur antenatally (83%) or intrapartum (...
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Gastric Cancer: A Review
Importance Globally, 968 350 new cases and 659 853 deaths from gastric cancer were reported in 2022. In the US, 30 300 new cases and 10 780 deaths were estimated in 2025.
Observations Gastric cancer is more common in men, and the median age at diagnosis is 68 years. Most gastric cancers...
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New Cervical Cancer Screening Guidelines From the US Department of Health and Human Services: Strengthening Women’s Preventive Health
Cervical cancer screening is one of the most significant public health accomplishments of the 20th century. Over the last 50 years, incidence and mortality rates from cervical cancer in the US have decreased by more than 50%1 because of widespread use of the Papanicolaou test and later adoption...
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What Parents Need to Know About Sleep in Children
Half of all children have sleep issues at some point during childhood.
When a child does not sleep well, the entire family feels the impact. Sleep supports growth and development and prevents other illnesses. Poor sleep can lead to daytime irritability, trouble focusing, behavioral issues...
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Online Unsupervised Tai Chi Intervention for Knee Pain and Function in People With Knee Osteoarthritis: The RETREAT Randomized Clinical Trial
Importance Tai chi is a type of exercise recommended for knee osteoarthritis, but access to in-person tai chi can be limited.
Objective To evaluate the effects of an unsupervised multimodal online tai chi intervention on knee pain and function for people with knee osteoarthritis.
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Chronic kidney disease
Globally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. By 2050, chronic kidney disease is projected to become the fifth leading underlying cause of...
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