Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US.1 Approximately 1 in 32 women in the US will develop endometrial cancer in their lifetimes. Eighty percent of endometrial cancer cases in the US are diagnosed in postmenopausal...
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Does This Patient Have Volume Overload?: The Rational Clinical Examination
Importance Accurate assessment of intravascular volume facilitates management decisions about fluid management in patients with volume overload.
Objective To identify the most accurate clinical examination, radiographic, and laboratory findings for assessing volume overload in...
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Where Can I Find Reliable Information About Vaccines?
Vaccination has prevented serious illness and death in children and adults for more than 200 years. However, conflicting statements and misleading information about the benefits and risks of vaccines are becoming more common. This is especially true on the internet and social media. Many of...
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Management of Orthostatic Hypotension: A Review
Importance: Orthostatic hypotension is a common but underrecognized condition that increases with age and is associated with a lower quality of life, falls, and increased mortality. The frequent coexistence of supine hypertension and postprandial hypotension with orthostatic hypotension makes it...
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Does This Child Have a Concussion?: The Rational Clinical Examination Systematic Review
Importance: Concussion is a mild traumatic brain injury with associated abnormalities in brain function, rather than structural injury. An estimated 1.1 million to 1.9 million pediatric concussions occur annually in the US.
Objective: To determine the accuracy of clinical history and...
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Celiac Disease
Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA antibodies against tissue transglutaminase, and may include tests to confirm the presence of...
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Clinical Examination of the Lumbar Spine
Low back pain is one of the most common causes of health care visits and has the highest global prevalence of all musculoskeletal conditions. Although musculoskeletal back pain is often temporary and self-limited, it may represent more worrisome pathologic conditions that can lead to permanent...
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What Parents Need to Know About Moles in Children
Moles can be seen at birth, but most appear during childhood, increase in adolescence, and can continue to increase in number until about age 40 years. Most moles are harmless, and these benign moles can grow as the child grows. However, when moles change in certain ways, as described below, a...
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Transformative therapies for sickle cell disease
Sickle cell disease (SCD) is associated with major morbidity, reduced life expectancy, and impaired quality of life.
Transformative therapies for SCD include allogeneic hematopoietic stem cell transplant and gene therapy.
After successful transformative therapy, people with SCD no...
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2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Aim: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol."
Methods: A comprehensive literature...
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