The treatment of breast cancer has evolved largely based on refinements in understanding of the biology of the disease and the variable risk for mortality among separate disease subtypes.1 Further, due to...
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Sexually Transmitted Infections
This collection features the best content from AFP, as identified by the AFP editors, on sexually transmitted disease and related issues, including chlamydia, genital herpes, gonorrhea, human papillomavirus, and syphilis. New research may affect the interpretation and...
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Screening for Breast Cancer in Average-Risk Women: A Guidance Statement From the American College of Physicians
Description:
The purpose of this guidance statement is to provide advice to clinicians on breast cancer screening in average-risk women based on a review of existing guidelines and the evidence they include.
Methods:
This guidance statement is derived from an appraisal of...
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What Are Polygenic Scores and Why Are They Important?
Mendelian disorders and monogenic traits result from combinations of variants in 1 or a few genes that have a large effect on the propensity...
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The 10 Building Blocks of High-Performing Primary Care
Our experiences studying exemplar primary care practices, and our work assisting other practices to become more patient centered, led to a formulation of the essential elements of primary care, which we call the 10 building blocks of high-performing primary care. The building blocks include 4...
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Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis
We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between...
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Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus
BACKGROUND:
A number of health benefits are associated with intake of soluble, viscous, gel-forming fibers, including reduced serum cholesterol and the attenuation of postprandial glucose excursions.
OBJECTIVE:
We assess the effects of psyllium, which is a soluble, gel-...
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Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial
IMPORTANCE:
Sport-related concussion (SRC) is a significant public health problem without an effective treatment.
OBJECTIVE:
To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase...
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Hepatitis (and Other Liver Diseases)
This collection features the best content from AFP, as identified by the AFP editors, on hepatitis and other liver disease and related issues, including cirrhosis, chronic liver failure, hemochromatosis, hepatitis A, hepatitis B, hepatitis C, jaundice, and nonalcoholic fatty...
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Adverse Effects of First-line Pharmacologic Treatments of Major Depression in Older Adults
Objective. To assess selected adverse events of antidepressants in the treatment of major depressive disorder (MDD) in adults 65 years old or older. Antidepressants included in this review, as determined by expert opinion, are selective serotonin reuptake inhibitors (SSRIs),...
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