Objective. To summarize the effects of long-term osteoporosis drug treatment (ODT) and ODT discontinuation and holidays on fractures and harms.
Data sources. MEDLINE®, Embase®, and Cochrane databases from 1995 to October 2018; ClinicalTrials.gov;...
Recent Resources
Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
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Cannabidiol (CBD) - What we know and what we don't
Cannabidiol (CBD) has been recently covered in the media, and you may have even seen it as an add-in booster to your post-workout smoothie or morning coffee. What exactly is CBD? Why is it suddenly so popular?
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Association of State Laws With Influenza Vaccination of Hospital Personnel
Introduction
Healthcare personnel influenza vaccination can reduce influenza illness and patient mortality. State laws are one tool promoting healthcare personnel influenza vaccination.
Methods
A 2016 legal assessment in 50 states and Washington DC identified (1) assessment...
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Disseminated Gonococcal Infection
A 20-year-old woman presented to the emergency department with a rash involving the arms, legs, trunk, and scalp, which had erupted that morning . . .
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Thrombotic Thrombocytopenic Purpura
A 35-year-old man presented to the emergency department with a 2-day history of abdominal pain, headache, and brown urine . . .
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Does CBD Actually Work?
Perhaps you’ve heard a lot of people are using CBD.
The chemical compound, naturally occurring in cannabis plants, doesn’t get you high, but does have a wide swath of other purported...
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Influence of changes in diet quality on unhealthy aging: the Seniors-ENRICA cohort
Background
Whether adopting a better diet in late life influences the aging process is still uncertain. Thus, we examined the association between changes in diet quality and unhealthy aging.
Methods
Data came from 2042 individuals aged ≥ 60 years recruited in the Seniors-...
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A Systematic Review of Trials to Improve Child Outcomes Associated With Adverse Childhood Experiences
Context
The purpose of this systematic literature review was to summarize current evidence from RCTs for the efficacy of interventions involving pediatric health care to prevent poor outcomes associated with adverse childhood experiences measured in childhood (C-ACEs).
Evidence...
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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
BACKGROUND
Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve...
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Tapering Long-term Opioid Therapy in Chronic Noncancer Pain: Evidence and Recommendations for Everyday Practice
Increasing concern about the risks and limited evidence supporting the therapeutic benefit of long-term opioid therapy for chronic noncancer pain are leading prescribers to consider discontinuing the use of opioids. In addition to overt addiction or diversion, the presence of adverse effects,...
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