Importance: Pharmacologic interventions for addressing social impairments in autism spectrum disorder (ASD) are lacking. Proton magnetic resonance spectroscopy (1H-MRS) studies in individuals with ASD have documented altered glutamate levels in the pregenual anterior cingulate cortex (pgACC)....
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Memantine to Treat Social Impairment in Youths With Autism Spectrum Disorder A Randomized Clinical Trial
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Self-Collection for Cervical Cancer Screening in a Safety-Net Setting: The PRESTIS Randomized Clinical Trial
Importance There are limited data on the effectiveness of mailed self-collection to increase cervical cancer screening (CCS) participation in underresourced health care settings.
Objective To compare the effectiveness of mailed self-collection kits, with and without patient navigation,...
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Self-Collection for Cervical Cancer Screening in a Safety-Net Setting: The PRESTIS Randomized Clinical Trial
Importance There are limited data on the effectiveness of mailed self-collection to increase cervical cancer screening (CCS) participation in underresourced health care settings.
Objective To compare the effectiveness of mailed self-collection kits, with and without patient navigation,...
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Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults: A Randomized Clinical Trial
Importance The wide use of unregulated cannabidiol (CBD) products among consumers raises safety concerns. Most research on CBD has studied the relatively high doses used by patients taking prescription CBD. However, limited safety data are available at lower doses.
Objective To study...
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Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation: The ALONE-AF Randomized Clinical Trial
Importance: Data from randomized clinical trials on a long-term anticoagulation strategy for patients after catheter-based ablation for atrial fibrillation (AF) are lacking.
Objective: To evaluate whether discontinuing oral anticoagulant therapy provides superior clinical outcomes...
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Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation
Background: The appropriate antithrombotic regimen for patients with chronic coronary syndrome who are at high atherothrombotic risk and receiving long-term oral anticoagulation remains unknown.
Methods: We conducted a multicenter, double-blind, randomized, placebo-controlled trial in...
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Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial
Importance: Existing pharmacological treatments for insomnia have significant limitations.
Objective: To assess the effective dose range, safety, and tolerability of the novel selective orexin-2 receptor antagonist seltorexant in insomnia disorder.
Design, setting, and participants...
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As-Needed Albuterol–Budesonide in Mild Asthma
Background: As-needed use of albuterol-budesonide has been shown to result in a significantly lower risk of severe asthma exacerbation than as-needed use of albuterol alone among patients with moderate-to-severe asthma. Data on albuterol-budesonide in mild asthma are needed.
Methods: We...
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Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial
Background: Surgery and corticosteroid injections are established treatments for carpal tunnel syndrome, but the optimal treatment strategy remains unclear. This study aimed to compare starting treatment with surgery versus starting with a corticosteroid injection.
Methods: We conducted...
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Metformin for Knee Osteoarthritis in Patients With Overweight or Obesity: A Randomized Clinical Trial
Importance: Preclinical and preliminary human evidence suggests that metformin, a first-line treatment for type 2 diabetes, reduces inflammation, preserves cartilage, and improves knee pain in knee osteoarthritis.
Objective: To evaluate the effects of metformin on knee pain at 6 months in...
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