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Why We Should Target Small Airways Disease in Our Management of Chronic Obstructive Pulmonary Disease

Author/s: Usmani, O., Dhand, R., Lavorini, F., Price, D.

For more than 50 years, small airways disease has been considered a key feature of chronic obstructive pulmonary disease (COPD) and a major cause of airway obstruction. Both preventable and treatable, small airways disease has important clinical consequences if left unchecked. Small airways...

Keywords/Tags:
Small Airways Disease chronic obstructive pulmonary disease copd

Milestones in Heart Failure: How Far We Have Come and How Far We Have Left to Go

Author/s: H., Kela, I., Kakarlala, C., Hassan, M., Belavadi, R., Gudigopuram, S. V. R., Raguthu, C., Modi, S., Sange, I.

Heart failure is a clinically complex syndrome that results due to the failure of the ventricles to function as pump and oxygenate end organs. The repercussions of inadequate perfusion are seen in the form of sympathetic overactivation and third spacing, leading to clinical signs of increased...

Keywords/Tags:
heart failure Cardiology Ventricles blood pressure

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

Author/s: Bernal, A. J., Gomes da Silva, M., Musungaie, D., Kovalchuk, E., Gonzalez, A., Delos Reyes, V., Martin-Quiros, A., Caraco, Y., Williams-Diaz, A., Brown, M., Du, J., Pedley, A., Assaid, C., Strizki, J., Grobler, J., Shamsuddin, H., Tipping, R., Wan, H., Paschke, A., Butterton, J., Johnson, M., De Anda, C., MOVe-OUT Study Group

Abstract
Background: New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: We...

Keywords/Tags:
Molnupiravir Oral Treatment COVID-19 Nonhospitalized Patients

COVID-19 and Pregnancy

Author/s: Walter, K.

Pregnant and recently pregnant individuals who become infected with the COVID-19 virus
are at high risk of requiring extra medical care.
According to the Centers for Disease Control and Prevention (CDC),
between January 22, 2020, and November 29, 2021, 148 327
pregnant...

Keywords/Tags:
Pregnancy COVID-19 Center for Disease Control CDC

Screening and Interventions to Prevent Dental Caries in Children Younger Than 5 Years US Preventive Services Task Force Recommendation Statement

Author/s: US Preventative Services task Force

IMPORTANCE Dental caries is the most common chronic disease in children in the US.
According to the 2011-2016 National Health and Nutrition Examination Survey, approximately
23% of children aged 2 to 5 years had dental caries in their primary teeth. Prevalence is higher
in...

Keywords/Tags:
Dental Caries screening Intervention children

Dietary Approaches to Improve Efficacy and Control Side Effects of Levodopa Therapy in Parkinson's Disease: A Systematic Review

Author/s: Boelens Keun, J., Arnoldussen, I., Vriend, C., Van de Rest, O.

Although levodopa remains the most effective drug for symptomatic management of Parkinson's Disease (PD), treatment during advanced disease stages may raise unpredictable motor fluctuations and other complications. Counteracting these complications with other pharmacological therapies may prompt...

Keywords/Tags:
diet Levodopa Therapy Parkinson's Disease PD Side Effects

Infectious Diseases Society of America Guidelines on Infection Prevention for Healthcare Personnel Caring for Patients with Suspected or Known COVID-19

Author/s: Lynch, J. B., Davitkov, P., Anderson, D. J., Bhimraj, A., Cheng, V. C. C., Guzman-Cottrill, J., Dhindsa, J., Duggal, A., Jain, M. K., Lee, G. M., Liang, S. Y., McGeer, A., Varghese, J., Lavergne, V., Murad, M. H., Mustafa, R. A., Sultan, S., Falck-Ytter, Y., Morgan, R. L.

Background: Since its emergence in late 2019, SARS-CoV-2 continues to pose a risk to healthcare personnel (HCP) and patients in healthcare settings. Although all clinical interactions likely carry some risk of transmission, human actions like coughing and care activities like aerosol-generating...

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

Author/s: Glauser, T., Shinnar, S., Gloss, D., Alldredge, B., Arya, R., Bainbridge, J., Bare, M., Bleck, T., Dodson, W. E., Garrity, L., Jagoda, A., Lowenstein, D., Pellock, J., Riviello, J., Sloan, E., Treiman, D. M.

CONTEXT: The optimal pharmacologic treatment for early convulsive status epilepticus is unclear. OBJECTIVE: To analyze efficacy, tolerability and safety data for anticonvulsant treatment of children and adults with convulsive status epilepticus and use this analysis to develop an evidence-based...

The frequency and impact of undiagnosed benign paroxysmal positional vertigo in outpatients with high falls risk

Author/s: Hawke, L. J., Barr, C. J., McLoughlin, J. V.

Background
The frequency and impact of undiagnosed benign paroxysmal positional vertigo (BPPV) in people identified with high falls risk has not been investigated.

Objective
To determine the frequency and impact on key psychosocial measures of undiagnosed BPPV in adult...

Cervical cancer screening guideline for individuals at average risk

Author/s: Chor, J., Davis, A. M., Rusiecki, J. M.

Major recommendations

Begin screening at age 25 years regardless of sexual history or HPV vaccination status (strong recommendation)

Primary HPV testing every 5 years through age 65 years (strong recommendation)

If primary HPV testing is not available use cotesting (HPV+...

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