Chronic diarrhea is defined as loose or watery stools lasting longer than 4 weeks and affects approximately 6% to 7% of adults in the US. More than 90% of patients with chronic diarrhea have a noninfectious etiology.
Observations The most common causes of chronic, noninfectious diarrhea...
Endometrial cancer accounts for 95% of uterine cancers, which are the fourth most common cancer in women in the US.1 Approximately 1 in 32 women in the US will develop endometrial cancer in their lifetimes. Eighty percent of endometrial cancer cases in the US are diagnosed in postmenopausal...
Importance Accurate assessment of intravascular volume facilitates management decisions about fluid management in patients with volume overload.
Objective To identify the most accurate clinical examination, radiographic, and laboratory findings for assessing volume overload in...
Vaccination has prevented serious illness and death in children and adults for more than 200 years. However, conflicting statements and misleading information about the benefits and risks of vaccines are becoming more common. This is especially true on the internet and social media. Many of...
Importance: Orthostatic hypotension is a common but underrecognized condition that increases with age and is associated with a lower quality of life, falls, and increased mortality. The frequent coexistence of supine hypertension and postprandial hypotension with orthostatic hypotension makes it...
Importance: Concussion is a mild traumatic brain injury with associated abnormalities in brain function, rather than structural injury. An estimated 1.1 million to 1.9 million pediatric concussions occur annually in the US.
Objective: To determine the accuracy of clinical history and...
Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA antibodies against tissue transglutaminase, and may include tests to confirm the presence of...
Low back pain is one of the most common causes of health care visits and has the highest global prevalence of all musculoskeletal conditions. Although musculoskeletal back pain is often temporary and self-limited, it may represent more worrisome pathologic conditions that can lead to permanent...
Moles can be seen at birth, but most appear during childhood, increase in adolescence, and can continue to increase in number until about age 40 years. Most moles are harmless, and these benign moles can grow as the child grows. However, when moles change in certain ways, as described below, a...
Sickle cell disease (SCD) is associated with major morbidity, reduced life expectancy, and impaired quality of life.
Transformative therapies for SCD include allogeneic hematopoietic stem cell transplant and gene therapy.
After successful transformative therapy, people with SCD no...
