Vaccination has prevented serious illness and death in children and adults for more than 200 years. However, conflicting statements and misleading information about the benefits and risks of vaccines are becoming more common. This is especially true on the internet and social media. Many of...
Recent Resources
Management of Orthostatic Hypotension: A Review
Importance: Orthostatic hypotension is a common but underrecognized condition that increases with age and is associated with a lower quality of life, falls, and increased mortality. The frequent coexistence of supine hypertension and postprandial hypotension with orthostatic hypotension makes it...
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Does This Child Have a Concussion?: The Rational Clinical Examination Systematic Review
Importance: Concussion is a mild traumatic brain injury with associated abnormalities in brain function, rather than structural injury. An estimated 1.1 million to 1.9 million pediatric concussions occur annually in the US.
Objective: To determine the accuracy of clinical history and...
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Celiac Disease
Celiac disease, a common autoimmune condition affecting approximately 1% of the population, can develop with exposure to gluten at any age. Diagnosis involves serologic testing, especially for IgA antibodies against tissue transglutaminase, and may include tests to confirm the presence of...
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Clinical Examination of the Lumbar Spine
Low back pain is one of the most common causes of health care visits and has the highest global prevalence of all musculoskeletal conditions. Although musculoskeletal back pain is often temporary and self-limited, it may represent more worrisome pathologic conditions that can lead to permanent...
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What Parents Need to Know About Moles in Children
Moles can be seen at birth, but most appear during childhood, increase in adolescence, and can continue to increase in number until about age 40 years. Most moles are harmless, and these benign moles can grow as the child grows. However, when moles change in certain ways, as described below, a...
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Transformative therapies for sickle cell disease
Sickle cell disease (SCD) is associated with major morbidity, reduced life expectancy, and impaired quality of life.
Transformative therapies for SCD include allogeneic hematopoietic stem cell transplant and gene therapy.
After successful transformative therapy, people with SCD no...
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2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Aim: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol."
Methods: A comprehensive literature...
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Diagnosis and Management of Resistant Hypertension: A Review
Importance: Hypertension, defined as office systolic blood pressure (SBP) 130 mm Hg or greater and/or diastolic blood pressure 80 mm Hg or greater, affects 43.9% of women and 49.5% of men in the US. Approximately 19.7% of patients treated for hypertension have apparent resistant hypertension (...
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Management of Hypertension in Adults
Hypertension is the leading modifiable risk factor worldwide for ASCVD, and approximately half of US adults have hypertension.1 Uncontrolled BP contributes to heart failure, stroke, atrial fibrillation, and sudden cardiac death and is associated with development of kidney failure and dementia.2...
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