Hormone therapy is the most effective treatment for managing menopausal vasomotor symptoms. Hot flashes and night sweats affect approximately 70% of midlife women and may persist for a decade or longer.1 ...
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Association of Nonfasting vs Fasting Lipid Levels With Risk of Major Coronary Events in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm
IMPORTANCE:
Recent guidelines have recommended nonfasting for routine testing of lipid levels based on comparisons of nonfasting and fasting populations. However, no previous study has examined the association of cardiovascular outcomes with fasting vs nonfasting lipid levels measured in...
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Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults
BACKGROUND
Bariatric surgery results in weight loss and health improvements in adults and adolescents. However, whether outcomes differ according to the age of the patient at the time of surgery is unclear.
METHODS
We evaluated the health effects of Roux-en-Y gastric bypass...
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2018 Cholesterol Clinical Practice Guidelines: Synopsis of the 2018 American Heart Association/American College of Cardiology/Multisociety Cholesterol Guideline
Description:
In November 2018, the American Heart Association and American College of Cardiology (AHA/ACC) released a new clinical practice guideline on cholesterol management. It was accompanied by a risk assessment report on primary prevention of atherosclerotic cardiovascular disease (...
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The Many Faces of Cobalamin (Vitamin B12) Deficiency
Although cobalamin (vitamin B12) deficiency was described over a century ago, it is still difficult toestablish the correct diagnosis and prescribe the right treatment. Symptoms related to vitamin B12 deficiency may be diverse and vary from neurologic to psychiatric. A number of individuals with...
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The Many Faces of Cobalamin (Vitamin B12) Deficiency
Although cobalamin (vitamin B12) deficiency was described over a century ago, it is still difficult toestablish the correct diagnosis and prescribe the right treatment. Symptoms related to vitamin B12 deficiency may be diverse and vary from neurologic to psychiatric. A number of individuals with...
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New Approaches to Management of Depression
Interview with Andrew A. Nierenberg, MD, author of Evolving Issues in the Treatment of Depression
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Grommets (ventilation tubes) for recurrent acute otitis media in children
BACKGROUND:
Acute otitis media (AOM) is one of the most common childhood illnesses. While many children experience sporadic AOM episodes, an important group suffer from recurrent AOM (rAOM), defined as three or more episodes in six months, or four or more in one year. In this subset of ...
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Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
BACKGROUND:
Optimal long-term osteoporosis drug treatment (ODT) is uncertain.
PURPOSE:
To summarize the effects of long-term ODT and ODT discontinuation and holidays.
DATA SOURCES:
Electronic bibliographic databases (January 1995 to October 2018) and systematic...
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Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma
BACKGROUND:
In double-blind, placebo-controlled trials, budesonide-formoterol used on an as-needed basis resulted in a lower risk of severe exacerbation of asthma than as-needed use of a short-acting β2-agonist (SABA); the risk was similar to that of budesonide maintenance therapy plus as...
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