This JAMA Clinical Guidelines Synopsis summarizes the 2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations for inhaled pharmacotherapy for stable COPD.
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Diagnosis and Treatment of Type 2 Diabetes in Adults A Review
Importance: Type 2 diabetes involves progressive loss of insulin secretion from pancreatic β cells in the setting of insulin resistance and manifests clinically as hyperglycemia. Type 2 diabetes accounts for 90% to 95% of all cases of diabetes globally, with estimates ranging from 589 million to...
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New Frontier, New Challenges—Recognizing and Managing Adverse Effects of Antiamyloid Therapies
This clinical insight discusses the diagnosis and management of adverse effects of antiamyloid therapies and what medications require consideration or avoidance.
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Early Invasive or Conservative Strategies for Older Patients With Acute Coronary Syndromes: A Meta-Analysis
Importance: The optimal management strategy for older patients who present with acute coronary syndrome (ACS) remains unclear due to a paucity of randomized evidence. New large and longer-term randomized data are available.
Objective: To test the association of an early invasive strategy...
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Occupational Heat-Related Illness
This JAMA Insights proposes solutions to help reduce the risk of heat-related illnesses among workers.
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Adrenal Insufficiency in Adults: A Review
Importance: Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal...
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Reframing Micronutrient Deficiencies for Modern times: A Review
Micronutrient deficiencies are often discounted in as an entity of the past when access to quality nutrition was scarce. However modern-day conditions such as hemodialysis, complex medication interactions, parenteral nutrition, gastrointestinal resections, institutional living, and substance use...
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Uveitis in Adults
Importance: Uveitis is characterized by inflammation of the uvea—the middle portion of the eye composed of the iris, ciliary body, and choroid—causing eye redness, pain, photophobia, floaters, and blurred vision. Untreated uveitis may cause cataracts, glaucoma, macular edema, retinal detachment...
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Diverticulitis in Older Adults: A Review of Etiology, Diagnosis, and Management
Background: Diverticulitis accounts for over 300,000 hospitalizations annually in the United States and its incidence increases with age. Among older adults, diverticulitis is the fourth leading cause for emergency surgery. Older adults with multimorbidity and geriatric syndromes are often...
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