University of Oklahoma Health Sciences Center

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Author/s:

Godfred-Cato, S., Bryant, B., Leung, J.

Date Added:

August 11, 2020

Journal/Publication:

Morbidity and Mortality Weekly Report

Publisher:

Centers for Disease Control and Prevention

Publication Date:

August 7, 2020

URL:

COVID-19–Associated Multisystem Inflammatory Syndrome in Children — United States, March–July 2020

Type:

Clinical Research Results

Format:

Article

DOI (1):

http://dx.doi.org/10.15585/mmwr.mm6932e2

MeSH

health personnel

Early Diagnosis

Public Health Practice

Inflammation

RPR Commentary

A summary from the CDC of what is currently known about COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C) in the U.S. James W. Mold, MD, MPH

Abstract

Summary

What is already known about this topic?

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe condition that has been reported approximately 2–4 weeks after the onset of COVID-19 in children and adolescents.

What is added by this report?

Most cases of MIS-C have features of shock, with cardiac involvement, gastrointestinal symptoms, and significantly elevated markers of inflammation, with positive laboratory test results for SARS-CoV-2. Of the 565 patients who underwent SARS-CoV-2 testing, all had a positive test result by RT-PCR or serology.

What are the implications for public health practice?

Distinguishing MIS-C from other severe infectious or inflammatory conditions poses a challenge to clinicians caring for children and adolescents. As the COVID-19 pandemic continues to expand in many jurisdictions, health care provider awareness of MIS-C will facilitate early recognition, early diagnosis, and prompt treatment.

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