Videos from the Patient-Centered Outcomes Research Institute on the prevention of stroke in patients with atrial fibrillation.
Recent Resources
Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial
BACKGROUND::
Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with...
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Radical Prostatectomy or Watchful Waiting in Prostate Cancer - 29-Year Follow-up
BACKGROUND
Radical prostatectomy reduces mortality among men with clinically detected localized prostate cancer, but evidence from randomized trials with long-term follow-up is sparse.
METHODS
We randomly assigned 695 men with localized prostate cancer to watchful waiting or...
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Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain The SPACE Randomized Clinical Trial
Importance Limited evidence is available regarding long-term outcomes of opioids compared with nonopioid medications for chronic pain.
Objective To compare opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and...
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Brief physician advice for problem alcohol drinkers. A randomized controlled trial in community-based primary care practices
OBJECTIVE:
Project TrEAT (Trial for Early Alcohol Treatment) was designed to test the efficacy of brief physician advice in reducing alcohol use and health care utilization in problem drinkers.
DESIGN:
Randomized controlled clinical trial with 12-month follow-up.
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Brief physician and nurse practitioner-delivered counseling for high-risk drinking. Results at 12-month follow-up
BACKGROUND:
The objective of this study was to determine the effects of a brief primary care provider-delivered counseling intervention on the reduction of alcohol consumption by high-risk drinkers. The intervention was implemented as part of routine primary care medical practice.
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Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding.
IMPORTANCE:
Anticoagulant choice and proton pump inhibitor (PPI) cotherapy could affect the risk of upper gastrointestinal tract bleeding, a frequent and potentially serious complication of oral anticoagulant treatment.
OBJECTIVES:
To compare the incidence of hospitalization...
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Glucose Self-monitoring in Non–Insulin-Treated Patients With Type 2 Diabetes in Primary Care Settings
IMPORTANCE:
The value of self-monitoring of blood glucose (SMBG) levels in patients with non-insulin-treated type 2 diabetes has been debated.
OBJECTIVE:
To compare 3 approaches of SMBG for effects on hemoglobin A1c levels and health-related quality of life (HRQOL) among...
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Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents
BACKGROUND:
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.
METHODS:
We conducted two...
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Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial
Importance
Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets.
Objective
To...
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