Purpose of review: Prescribed and non-prescribed cannabis use is common. Providers in specialties treating chronic pain – primary care, pain management, and neurology–will be coming across medical cannabis as a treatment for chronic pain, regardless of whether they are prescribers. It is...
Library & Search Results
Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events
Background: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear.
Methods: In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of...
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Prescribing for common complications of spinal cord injury
Objective: To describe prescribing patterns for 3 common complications associated with spinal cord injury (SCI) and to provide family doctors with strategies for optimizing the care of patients with SCI.
Sources of information: Results of a nationwide survey of prescription medication use...
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Cost-effectiveness of management strategies in recurrent acute otitis media
Objective: To evaluate the cost-effectiveness of tympanostomy tube placement vs. nonsurgical medical management, with the option of tympanostomy tube placement in the event of treatment failure, in children with recurrent acute otitis media (AOM).
Study design: A Markov decision model...
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Long-Term Health Outcomes in Obstructive Sleep Apnea: A Systematic Review of Comparative Studies Evaluating Positive Airway Pressure and the Validity of Breathing Measures as Surrogate Outcomes
Background. Obstructive sleep apnea (OSA) is a disorder characterized by periods of airflow
cessation (apnea) or reduced airflow (hypopnea) during sleep. The diagnosis and severity of
OSA, and response to therapy, have historically been assessed using the apnea-hypopnea index
(...
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Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children
Objectives: The objective of the study was to compare the antibiotic treatment failure and recurrence rates between antibiotic agents (amoxicillin, amoxicillin-clavulanate, cefdinir, and azithromycin) for children with uncomplicated acute otitis media (AOM).
Study design: We completed a...
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Health benefits of physical activity: the evidence
The primary purpose of this narrative review was to evaluate the current literature and to provide further insight into the role physical inactivity plays in the development of chronic disease and premature death. We confirm that there is irrefutable evidence of the effectiveness of regular...
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Individualized antidepressant therapy in patients with major depressive disorder: Novel evidence-informed decision support tool
Objective: To introduce a visual clinical decision support tool to assist with individualizing first-line antidepressant pharmacotherapy for adults with major depressive disorder (MDD) in a Canadian context.
Sources of information: A literature review was conducted with Google Scholar,...
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Alcohol Use Disorder and Alcohol-Associated Liver Disease
This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent institute of the National Institutes of Health,...
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Suicide Prevention in Primary Care: A Toolkit for Primary Care Clinicians and Leaders
Suicide prevention has been named a national priority and much work has been done to review existing evidence and identify gaps in how our nation’s mental health and health care systems address this public health challenge. A national task force that was part of the effort to update the national...
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