Importance: Approximately 19.7% of children and adolescents aged 2 to 19 years in the US have a body mass index (BMI) at or above the 95th percentile for age and sex, based on Centers for Disease Control and Prevention growth charts from 2000. The prevalence of high BMI increases with age and is...
Library & Search Results
Interventions for High Body Mass Index in Children and Adolescents: US Preventive Services Task Force Recommendation Statement
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Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial
Importance: Little is known about the relative effectiveness of nicotine-containing electronic cigarettes (ECs) compared with varenicline as smoking cessation aids.
Objective: To determine the relative effectiveness of ECs in smoking cessation.
Design, setting, and participants:...
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Optimization of type 2 diabetes care in adults aged 65 or older: Practical approach to deintensification
Effective diabetes management, particularly in older and frail adults, requires a nuanced approach that balances the benefits of antihyperglycemic medications with the risks of intensive glycemic control. While certain diabetes medications are important to the prevention of chronic complications...
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Diets
Food consumption provides essential and nonessential nutrients in the human body and thereby promotes growth and health. Individual food choice and the potential modification of eating habits are complex issues, influenced by the availability and acceptability of foods.1 The availability of...
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Sodium-Glucose Cotransporter-2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis
Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) consistently improve heart failure and kidney-related outcomes; however, effects on major adverse cardiovascular events (MACE) across different patient populations are less clear.
Methods: This was a collaborative trial-level...
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Olgotrelvir as a Single-Agent Treatment of Nonhospitalized Patients with Covid-19
Background: Olgotrelvir is an oral antiviral with dual mechanisms of action targeting severe acute respiratory syndrome coronavirus 2 main protease (i.e., Mpro) and human cathepsin L. It has potential to serve as a single-agent treatment of coronavirus disease 2019 (Covid-19).
Methods: We...
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Management of Depression in Adults: A Review
Importance: Approximately 9% of US adults experience major depression each year, with a lifetime prevalence of approximately 17% for men and 30% for women.
Observations: Major depression is defined by depressed mood, loss of interest in activities, and associated psychological and somatic...
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What Should I Know About Recurrent UTIs in Older Women?
This JAMA Internal Medicine Patient Page describes urinary tract infections, their causes, and how to treat them and prevent future episodes.
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Recurrent Urinary Tract Infection in Older Outpatient Women
This Clinical Insights discusses special considerations in recurrent urinary tract infection diagnosis and management in older women.
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Bacterial vaginosis
Bacterial vaginosis is the most common cause of abnormal vaginal discharge, affecting 23%–30% of reproductive-aged people
Bacterial vaginosis is caused by a disrupted vaginal microbiome balance. Symptoms include itch, dysuria, and a thin, grey discharge with a “fishy” odour, particularly...
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