Author/s: Chanchlani, Neil, Walters, Thomas D., Russell, Richard K.
KEY POINTS
• Children present frequently to primary and emergency care with nonspecific abdominal pain.
• Only a few treatment options exist to manage colicky, undifferentiated pain; however, most children will not present more than once or twice to health services for this problem...
Author/s: Joint Committee on Clinical Practice Guidelines
Author/s: Gupta, A., Waldfogel, J.M., Sharma, R., Feliciano, J.L., Sedhom, R., Day, J., Gersten, R.A., Davidson, P.M.
Main Points
For patients with advanced cancer:
- Airflow interventions (fans) were more effective for improving breathlessness compared with usual care or sham.
- Bilevel ventilation (a form of noninvasive positive pressure ventilation) was more effective than standard...
Author/s: Gencer, Baris, Marston, Nicholas A., Im, KyungAh, Cannon, Christopher P., Sever, Peter, Keech, Anthony, Braunwald, Eugene, Giugliano, Robert P., Sabatine, Marc S.
Background: The clinical benefit of LDL cholesterol lowering treatment in older patients remains debated. We aimed to summarise the evidence of LDL cholesterol lowering therapies in older patients.
Methods: In this systematic review and meta-analysis, we...
Author/s: Chandler, P.D., Chen, W.Y., Ojala, O.N.
Importance Epidemiologic and trial data suggest that vitamin D supplementation may reduce metastatic cancer and cancer mortality, reflecting shared biological pathways.
Objective To follow up on the possible reduction in cancer death in the Vitamin D...
Author/s: Garber, A.J., Handelsman, Y., Grunberger, G., Einhorn, D., Abrahamson, M.J., Barzilay, J.I., Blonde, L., Bush, M.A.
Author/s: Gregory A., Ovsyannikova , Inna G., Kennedy, Richard B.
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such as hyperimmune globulin and convalescent human plasma, and to developing vaccines, antivirals, and monoclonal antibodies...
Author/s: Ebell, M.H., Bentivegna, M., Hulme, C.
Abstract
Purpose: Benefit of lung cancer screening using low-dose computed tomography (LDCT) in reducing lung cancer-specific and all-cause mortality is unclear. We undertook a meta-analysis to assess its associations with outcomes.
Methods: We...
Author/s: Navaneethan, Sankar D., Zougas, Sophia, Caramori, M.L., Chan, Juliana C.N., Heerspink, Hiddo J.L., Hurst, Clint, Liew, Adrian, Michos, Erin D., Olowu, Wasiu A., Sadusky, Tami, Tandon, Nikhil, Tuttle, Katherine R., Wanner, Christoph, Wilkens, Katy G., Lytvyn, Lyubov, Craig, Jonathan C., Tunnicliffe, David J., Howell, Martin, Tonelli, Marcello, Cheung, Michael, Earley, Amy, Rossing, Peter, De Boer, Ian H., Khunti, Kamlesh
Description: The Kidney Disease: Improving Global Outcomes (KDIGO) organization developed a clinical practice guideline in 2020 for the management of patients with diabetes and chronic kidney disease (CKD).
Methods: The KDIGO Work Group (WG) was tasked...