A “no-biopsy” approach to diagnosing celiac disease

Author/s: 
Mott, T., Gray, C., Storey, J.
Date Added: 
October 25, 2022
Journal/Publication: 
Journal of Family Practice
Publisher: 
Frontline Medical Communications
Publication Date: 
October 1, 2022
Issue: 
8
Volume: 
71
Pages: 
359-361
Type: 
Meta-analyses, Reviews, and Guidelines
Format: 
Article
DOI (1): 
10.12788/jfp.0485

RPR Commentary

This antibody test is almost as good as a biopsy for diagnosing celiac disease. James W. Mold, MD, MPH

Abstract

PRACTICE CHANGER
CONSIDER A “NO-BIOPSY” APPROACH BY EVALUATING SERUM IMMUNOGLOBULIN (IG) A ANTI-TISSUE TRANSGLUTAMINASE (TTG-IGA) ANTIBODY TITERS IN ADULT PATIENTS WHO PRESENT WITH SYMPTOMS CONCERNING FOR CELIAC DISEASE (CD). AN INCREASE OF ≥ 10 TIMES THE UPPER LIMIT OF NORMAL (ULN) FOR TTG-IGA HAS A POSITIVE PREDICTIVE VALUE (PPV) OF ≥ 95% FOR DIAGNOSING CD WHEN COMPARED WITH ESOPHAGOGASTRODUODENOSCOPY (EGD) WITH DUODENAL BIOPSY—THE CURRENT GOLD STANDARD.

Text Availability

Free full text