Author/s: Rothwell, Peter M., Cook, Nancy R., Gaziano, J. Michael, Price, Jacqueline F., Blech, Jill F. F., Roncaglioni, Maria Carla, Morimoto, Takeshi, Mehta, Ziyah
BACKGROUND:
A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes...
Author/s: British Thoracic Society Standards of Care Committee, British Thoracic Society Pneumonia Guidelines Committee
The British Thoracic Society (BTS) Guidelines for the management of Community Acquired Pneumonia (CAP) in Adults was published in December 2001 and superseded Guidelines published in 1993. A web-based update of the 2001 Guidelines was published in 2004. The 2004 Guidelines assessed relevant...
Author/s: British Thoracic Society Standards of Care Committee, British Thoracic Society Pneumonia Guidelines Committee
The British Thoracic Society (BTS) Guidelines for the management of Community Acquired Pneumonia (CAP) in Adults was published in December 2001 and superseded Guidelines published in 1993. A web-based update of the 2001 Guidelines was published in 2004. The 2004 Guidelines assessed relevant...
Author/s: Buchbinder, Rachelle, Johnston, Renea V., Rischin, Kobi J., Jomik, Joanne, Jones, C. Allyson, Golmohammadi, Kamran, Kallmes, David F.
High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm.
Author/s: GBD 2016 Alcohol Collaborators
Background
Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the...
Author/s: Hooper, Lee, Al-Khudairy, Lena, Abdelhamid, Asmaa S., Rees, Karen, Brainard, Julii S., Brown, Tracey J., Ajabnoor, Sarah M., O'Brien, Alex T., Winstanley, Lauren E., Donaldson, Daisy H., Song, Fujian, Deane, Katherine H. O.
BACKGROUND:
Omega-6 fats are polyunsaturated fats vital for many physiological functions, but their effect on cardiovascular disease (CVD) risk is debated.
OBJECTIVES:
To assess effects of increasing omega-6 fats (linoleic acid (LA), gamma-linolenic acid (GLA), dihomo-gamma-...
Author/s: Ustun, Berk, Adler, Lenard A., Rudin, Cynthia, Faraone, Stephen V., Spencer, Thomas J., Berglund, Patricia, Gruber, Michael J., Kessler, Ronald C.
IMPORTANCE:
Recognition that adult attention-deficit/hyperactivity disorder (ADHD) is common, seriously impairing, and usually undiagnosed has led to the development of adult ADHD screening scales for use in community, workplace, and primary care settings. However, these scales are all...
Author/s: Vermandere, Mieke, Aertgeerts, Bert, Agoritsas, Thomas, Liu, Catherine, Burgers, Jako, Merglen, Arnaud, Okwen, Patrick Mbah, Lytvyn, Lyubov, Chua, Shunjie, Vandvik, Per O., Guyatt, Gordon H., Beltran-Arroyave, Claudia, Lavergne, Valéry, Speeckaert, Reinhart, Steen, Finn E., Arteaga, Victoria, Sender, Rachelle, McLeod, Shelley, Sun, Xin, Wang, Wen, Siemieniuk, Reed A.C.
What you need to know
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For uncomplicated skin abscesses, we suggest using trimethoprim-sulfamethoxazole (TMP-SMX) or clindamycin in addition to incision and drainage rather than incision and drainage alone, and emphasise the need for shared decision making
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TMP-...
Author/s: Forman-Hoffman, Valerie, Middleton, Jennifer Cook, Feltner, Cynthia, Gaynes, Bradley N., Weber, Rachel Palmieri, Bann, Carla, Viswanathan, Meera, Lohr, Kathleen N., Baker, Claire, Green, Joshua
Objective. To assess efficacy, comparative effectiveness, and harms of psychological and pharmacological treatments for adults with posttraumatic stress disorder (PTSD) and to update the original 2013 review.
Data sources. MEDLINE®, CINAHL®, Cochrane...
Author/s: Grossman, David C., Curry, Susan J., Owens, Douglas K., Barry, Michael J., Davidson, Karina W., Doubeni, Chyke A., Epling, John W. Jr., Kemper, Alex R., Krist, Alex H., Kurth, Ann E., Landefeld, Seth, Mangione, Carol M., Phipps, Maureen G., Silverstein, Michael, Simon, Melissa A., Tseng, Chien-Wen
IMPORTANCE:
With approximately 14 000 deaths per year, ovarian cancer is the fifth most common cause of cancer death among US women and the leading cause of death from gynecologic cancer. More than 95% of ovarian cancer deaths occur among women 45 years and older.
OBJECTIVE:
...