Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer’s patients, and levels correlated with tau and...
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Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
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Aspirin Use in Primary Care
An update for clinicians on the role of low-dose aspirin for prevention of cardiiovascular events from the Healthy Hearts for OK project.
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Blood Pressure Control in Primary Care
An update for clinicians on the role of blood pressure for prevention of cardiiovascular events from the Healthy Hearts for OK project.
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Cholesterol Management in Primary Care
An update for clinicians on the use of statins to prevent cardiiovascular events from the Healthy Hearts for OK project.
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Smoking Cessation in Primary Care
An update for clinicians on the importance of smoking cessation for the prevention of cardiiovascular events from the Healthy Hearts for OK project.
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Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials
BACKGROUND:
Randomised controlled trials (RCTs) of vitamin D to prevent COPDexacerbations have yielded conflicting results.Individual participant data meta-analysis could identify factors that explain this variation.
METHODS:
PubMed, Embase, the Cochrane Central Register of ...
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Antipsychotics for Children with Hyperactivity or Disruptive Disorders
New evidence can help clinicians, caretakers, and others weigh the benefits and harms of antipsychotic treatment for children and adolescents.
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How Will Treating My Early-Stage Prostate Cancer Affect My Quality of Life?
Early-stage prostate cancer can be treated in different ways. The three main ways are active surveillance, surgery, and radiotherapy. Active surveillance means having your prostate checked every few months to make sure the cancer is not spreading. Surgery would take out the prostate, and...
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Choosing Wisely - 5 Things Physicians & Patients Should Question
Don’t recommend daily home finger glucose testing in patients with Type 2 diabetes mellitus not using insulin.
Self-monitoring of blood glucose (SMBG) is an integral part of patient self-management in maintaining safe and target-driven glucose control in type 1 diabetes...
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Radical Prostatectomy or Watchful Waiting in Prostate Cancer - 29-Year Follow-up
BACKGROUND
Radical prostatectomy reduces mortality among men with clinically detected localized prostate cancer, but evidence from randomized trials with long-term follow-up is sparse.
METHODS
We randomly assigned 695 men with localized prostate cancer to watchful waiting or...
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