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APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

Author/s: Choudhury, Parichita, Ramanan, Vijay K., Boeve, Bradley F.

A 64-year-old man presented with concern about an abnormal genetic test result for apolipoprotein E (APOE) obtained through his primary care physician. He reported forgetfulness and word-finding difficulties for 3 years but performed all activities of daily living independently and was generally...

Keywords/Tags:
Alzheimer Disease aged elderly Elderly care elderly patients

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process

Author/s: Harwood, Rachel, Allin, Benjamin, Jones, Christine E., Whittaker, Elizabeth, Ramnarayan, Padmanabhan, Ramanan, Athimalaipet V., Kaleem, Musa, Tulloh, Robert, Peters, Mark J., Almond, Sarah, Davis, Peter J., Levin, Michael, Tometzki, Andrew, Faust, Saul N., Knight, Marian, Kenny, Simon

Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to provide guidance for clinicians caring for children with PIMS-TS. A...

Keywords/Tags:
COVID-19 SARS coronavirus SARS-CoV-2 coronavirus children

Update to CDC's Treatment Guidelines for Gonococcal Infection, 2020

Author/s: Syr, Sancta St., Lindley, Barbee, Workowski, Kimberly A., Bachmann, Laura, Pham, Cau, Schlanger, Karen, Torrone, Elizabeth

Not available
Keywords/Tags:
gonorrhea sexually transmitted infections treatment

Treatments for Acute Pain: A Systematic Review

Author/s: Agency for Healthcare Research and Quality

Not available
Keywords/Tags:
pain management

Clinical diagnosis of benign paroxysmal positional vertigo and vestibular neuritis

Author/s: Johns, Peter, Quinn, James

Not available
Keywords/Tags:
benign paroxysmal positional vertigo vestibular neuritis

Obesity in adults: a clinical practice guideline

Author/s: Wharton, Sean, Lau, David, Vallis, Michael, Sharma, Arya, Biertho, Laurent, Campbell-Scherer, Denise, Adamo, Kristi

Not available
Keywords/Tags:
obesity outcomes delivery of health care

Bupropion and Naltrexone in Methamphetamine Use Disorder

Author/s: Madhukar H., Walker, Robrina, Ling, Walter, Cruz, Adriane, Sharma, Guarav, Carmody, Thomas, Ghitza, Udi, Wahle, Aimee, Kim, Mora, Shores-Wilson, Kathy, Sparenborg, Steven, Coffin, Phillip

BACKGROUND

The use of naltrexone plus bupropion to treat methamphetamine use disorder has not been well studied.

METHODS

We conducted this multisite, double-blind, two-stage, placebo-controlled trial with the use of a sequential parallel comparison design to evaluate the...

Keywords/Tags:
methamphetamine addiction treatment

APOE ɛ4 Allele Testing and Risk of Alzheimer Disease

Author/s: Choudhury, Parichita, Boeve, Bradley F., Ramanan, Vijay K

A 64-year-old man presented with concern about an abnormal genetic test result for apolipoprotein E (APOE) obtained through his primary care physician. He reported forgetfulness and word-finding difficulties for 3 years but performed all activities of daily living independently and was...

Keywords/Tags:
dementia Alzheimer Disease Genetic testing

Weekly and Monthly Subcutaneous Buprenorphine Depot Formulations vs Daily Sublingual Buprenorphine With Naloxone for Treatment of Opioid Use Disorder: A Randomized Clinical Trial

Author/s: Lofwall, Michelle R., Walsh, Sharon L., Nunes, Edward V., Bailey, Genie L., Sigmon, Stacey C., Kampman, Kyle M., Frost, Michael, Tiberg, Fredrik, Linden, Marareta, Sheldon, Behshad, Oosman, Sonia, Peterson, Stefan, Chen, Michael, Kim, Sonnie

Importance: Buprenorphine treatment for opioid use disorder may be improved by sustained-release formulations.

Objective: To determine whether treatment involving novel weekly and monthly subcutaneous (SC) buprenorphine depot formulations is noninferior...

Keywords/Tags:
opioids Opioid Use Disorder Buprenorphine Buprenorphine-naloxone

Masks and Face Coverings for the Lay Public : A Narrative Update

Author/s: Czypionka, Thomas, Greenhalgh, Trisha, Bassler, Dirk, Bryant, Manuel B.

Whether and when to mandate the wearing of facemasks in the community to prevent the spread of coronavirus disease 2019 remains controversial. Published literature across disciplines about the role of masks in mitigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission...

Keywords/Tags:
face masks Face Coverings masks COVID-19 coronavirus SARS coronavirus SARS-CoV-2 Freedom Policy

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