In the last year, older adults in the U.S. sought medical care nearly 5 million times due to serious side effects from one or more medications. More than a quarter million of these visits resulted in hospitalizations, at a cost of $3.8 billion (see Appendix A in the full report). These numbers...
Recent Resources
Medication Overload: America’s Other Drug Problem. How the drive to prescribe is harming older adults.
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Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study
IMPORTANCE:
Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia.
OBJECTIVE:
To assess associations between anticholinergic drug treatments and risk of ...
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Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People
Introduction to the guidelines The Center of Excellence for Transgender Health (CoE) at the University of California – San Francisco is proud to present these Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People. Transgender people have a gender...
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Deficient Functioning of Frontostriatal Circuits During the Resolution of Cognitive Conflict in Cannabis-Using Youth
Abstract
OBJECTIVE:
Disturbances in self-regulatory control are involved in the initiation and maintenance of addiction, including cannabis use disorder. In adults, long-term cannabis use is associated with disturbances in frontostriatal circuits during tasks that require the...
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Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden
Abstract
OBJECTIVE:
To examine associations between gabapentinoids and adverse outcomes related to coordination disturbances (head or body injuries, or both and road traffic incidents or offences), mental health (suicidal behaviour, unintentional overdoses), and criminality.
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Ten tips for advancing a culture of improvement in primary care
Embracing practice-based quality improvement (QI) represents one way for clinicians to improve the care they provide to patients while also improving their own professional satisfaction. But engaging in care redesign is challenging for clinicians. In this article, we describe our experience over...
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Some benefits from donepezil in Alzheimer’s disease
CLINICAL QUESTION
How effective is exercise-based cardiac rehabilitation on mortality, morbidity, and health-related quality of life (QOL) in patients with coronary heart disease (CHD)?
BOTTOM LINE
Compared to usual care, in medium to longer-term follow-up (≥12 months)...
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Measles/Plan-for-Travel
Most measles cases in the U.S. result from international travel. Make sure you and your loved ones are protected against measles before international travel.
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The effects of sleep extension on cardiometabolic risk factors: A systematic review
Studies have shown bidirectional relationships between short- or long-sleep duration and risk for obesity, non-communicable diseases, all-cause mortality and cardiovascular disease mortality. Increasing sleep duration may be an appropriate strategy to reduce cardiometabolic riskin short-sleeping...
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Periprocedural Bridging in Patients with Venous Thromboembolism: A Systematic Review
Abstract
BACKGROUND:
Vitamin K antagonists (VKA) are the most widely used anticoagulants, and bridging is commonly administered during periprocedural VKA interruption. Given the unclear benefits and risks of periprocedural bridging in patients with previous venousthromboembolism,...
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