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Recent Resources

Confronting Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use

Author/s: Ford, Morgan A., Phillips, Jonathan K., Bonnie, Richard J.

The ongoing opioid crisis lies at the intersection of two substantial public health challenges—reducing the burden of suffering from pain and containing the rising toll of the harms that can result from the use of opioid medications. In March 2016, the U.S. Food and Drug Administration (FDA)...

Keywords/Tags:
opioids pain management chronic pain public health

Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma

Author/s: Sobieraj, Diana M., Baker, William L., Weeda, Erin R., Nguyen, Elaine, Coleman, Craig I., White, C. Michael, Lazarus, Stephen C., Blake, Kathryn V., Lang, Jason E.

Objective. To assess efficacy of intermittent inhaled corticosteroid (ICS) therapy in different populations (0 to 4 years old with recurrent wheezing, 5 years and older with persistent asthma, with or without long-acting beta agonist [LABA]), and to assess efficacy of added long...

Keywords/Tags:
asthma musacarinic antagonist corticosteroids

Omega-3 Fatty Acids and Cardiovascular Disease: Current State of the Evidence

Author/s: Balk, Ethan M., Adam, Gaelen P., Langberg, Valerie, Halladay, Christopher, Chung, Mei, Lin, Lin, Robertson, Sarah, Yip, Agustin, Steele, Dale, Smith, Bryant T., Lau, Joseph, Lichtenstein, Alice H., Trikalinos, Thomas A.

Focus of This Summary

This is a summary of a systematic review that evaluated the recent evidence regarding the effects of omega-3 fatty acids (FAs), primarily from marine oil supplements, on clinical and selected intermediate cardiovascular (CV) outcomes (i.e., blood pressure, lipid...

Keywords/Tags:
omega-3 fatty acids cholesterol blood pressure

Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review

Author/s: Skelly, Andrea C., Chou, Roger, Dettori, Joseph R., Turner, Judith A., Friedly, Janna L., Rundell, Sean D., Fu, Rongwei, Brodt, Erika D., Wasson, Ngoc, Winter, Cassandra, Ferguson, Aaron J. R.

Objectives. Many interventions are available to manage chronic pain; understanding the durability of treatment effects may assist with treatment selection. We sought to assess which noninvasive nonpharmacological treatments for selected chronic pain conditions are associated...

Keywords/Tags:
chronic pain nonpharmacological treatment noninvasive treatment

The Role of Immunotherapy in the Treatment of Asthma

Author/s: Lin, Sandra Y., Azar, Antoine, Suarez-Cuervo, Catalina, Diette, Gregory B., Brigham, Emily, Rice, Jessica, Ramanathan, Murugappan Jr., Gayleard, Jessica, Robinson, Karen A.

Objectives. To evaluate the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in the treatment of allergic asthma.

Data Sources. We searched PubMed, Embase, and CENTRAL through May 8, 2017.

Methods...

Keywords/Tags:
asthma SLIT SCIT subcutaneous immunotherapy sublingual immunotherapy

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

Author/s: Cholesterol Treatment Trialists' Collaboration

BACKGROUND:

Statin therapy has been shown to reduce major vascular events and vascular mortality in a wide range of individuals, but there is uncertainty about its efficacy and safetyamong older people. We undertook a meta-analysis of data from all large statin trials to compare the...

Keywords/Tags:
statin statin therapy cholesterol, LDL

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