1. Home
  2. Meta-analyses, Reviews, and Guidelines
  3. Recent Resources

Recent Resources

Interventions for Substance Use Disorders in Adolescents: A Systematic Review. Comparative Effectiveness Review No. 225

Author/s: Steele, CW, Becker, SJ, Danko, KJ, Balk, EM, Saldanha, IJ, Adam, GP, Bagley, SM, Friedman, C, Spirito, A, Scott, K, Ntzani, EE, Saeed, I, Smith, B, Popp, J, Trikalinos, TA

Objectives. This systematic review (SR) synthesizes the literature on behavioral, pharmacologic, and combined interventions for adolescents ages 12 to 20 years with problematic substance use or substance use disorder. We included interventions designed to achieve abstinence,...

Keywords/Tags:
substance use disorder adolescents alcohol use disorder cannabis use motivational interviewing pharmacological interventions

Using Insulin to Treat Poorly Controlled Type 2 Diabetes in 2020

Author/s: Hirsch, IB, Gaudiani, LM

No abstract available
Keywords/Tags:
type 2 diabetes insulin metformin blood gluclose

Estimating Lifetime Benefits of Comprehensive Disease-Modifying Pharmacological Therapies in Patients With Heart Failure With Reduced Ejection Fraction: A Comparative Analysis of Three Randomised Controlled Trials

Author/s: Vaduganathan, M., Claggett, BL, Jhund, PS, Cunningham, JW, Ferreira, JP, Zannad, F, Packer, M, Fonarow, GC, McMurray, JJV, Solomon, S.D.

Background: Three drug classes (mineralocorticoid receptor antagonists [MRAs], angiotensin receptor-neprilysin inhibitors [ARNIs], and sodium/glucose cotransporter 2 [SGLT2] inhibitors) reduce mortality in patients with heart failure with reduced ejection fraction (HFrEF)...

Keywords/Tags:
CHF patients heart failure pharmacologic management

Aspirin for Primary Atherosclerotic Cardiovascular Disease Prevention as Baseline Risk Increases: A Meta-Regression Analysis

Author/s: Nudy, M, Cooper, J, Ghahramani, M, Ruzieh, M, Mandrola, J, Foy, AJ

Background

Aspirin is often prescribed for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) however, recent randomized trials (RCTs) have challenged this practice. Despite this, aspirin is commonly recommended for high risk primary prevention. We tested the...

Keywords/Tags:
aspirin primary prevention Atherosclerotic Cardiovascular Disease myocardial infarction Ischemic Stroke Major Bleeding

Evidenced-Based Pharmacotherapies for Alcohol Use Disorder

Author/s: Fairbanks, J, Umbreit, A, Kolla, BP, Karpyak, VM, Schneekloth, TD, Loukianova, LL, Sinha, S

Pathologic alcohol use affects more than 2 billion people and accounts for nearly 6% of all deaths worldwide. There are three medications approved for the treatment of alcohol use disorder by the US Food and Drug Administration (FDA): disulfiram, naltrexone (oral and long-acting injectable), and...

Keywords/Tags:
alcohol use disorder pharmacotherapy disulfiram naltrexone acamprosate anticonvulsants Baclofen

Clinical Practice Guideline: Ménière's Disease Executive Summary

Author/s: Basura, GJ, Adams, ME, Monfared, A, Schwartz, SR, Antonelli, PJ, Burkard, R, Bush, ML, Bykowski, J, Colandrea, M, Derebery, J, Kelly, EA, Kerber, KA, Koopman, CF, Kuch, AA, Marcolini, E, McKinnon, BJ, Ruckenstein, MJ, Valenzuela, CV, Vosooney,A, Walsh, SA, Nnacheta, LC, Dhepyasuwan, N, Buchanan, EM

OBJECTIVE:

Ménière's disease (MD) is a clinical condition defined by spontaneous vertigo attacks (each lasting 20 minutes to 12 hours) with documented low- to midfrequency sensorineural hearing loss in the affected ear before, during, or after one of the episodes of vertigo. It also...

Keywords/Tags:
Meniett device electrocochleography endolymphatic hydrops endolymphatic sac decompression fluctuating aural symptoms gentamicin labyrinthectomy sensorineural hearing loss sodium-restricted diet vestibular testing

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

Author/s: Martineau, AR, Jolliffe, DA, Hooper, RL, Greenberg, L, Aloia, JF, Bergman, P, Dubnov-Raz, G, Esposito, S, Ganmaa, D, Ginde, AA, Goodall, EC, Grant, CC, Griffiths, CJ, Janssens, W, Laaksi, I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach, I, Kumar, GT, Urashima, M", CA Jr

Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.

Design Systematic review and meta-analysis of individual participant data (IPD) from...

Keywords/Tags:
vitamin D respiratory tract infections dietary supplements

Tummy Time and Infant Health Outcomes: A Systematic Review

Author/s: Hewitt, Lyndel, Kerr, Erin, Stanley, Rebecca, Okley, A.D.

Context: The World Health Organization recommends tummy time for infants because of the benefits of improved motor development and reduced likelihood of plagiocephaly. Because of poor uptake of these recommendations, the association of tummy time with other health outcomes...

Keywords/Tags:
tummy time parents benefits

St. John Health System Grand Rounds: Direct Oral Anticoagulants— The Good, The Bad, The Bloody

Author/s: Lepley, S., Strnad, C., Dixon, R., Wenger, J., Chow, G., Lesselroth, B., Ledbetter, M., Corbett, A.

Not available. 
Keywords/Tags:
St. John's Health System

Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia

Author/s: Hemmy, L.S, Fink, H.A., Linskens, E.J., Silverman, P.G., MacDonald, R., McCarten, J.R., Talley, K.M.C., Desai, P.J., Forte, M.L., Miller, M.A., Brasure, M., Nelson, V.A., Taylor, B.C., Ng, W., Ouellette, J.M., Greer, N.L., Sheets, K.M., Wilt, T.J., Butler, M.

Objective. To summarize evidence on: (1) the accuracy of brief cognitive tests for identifying clinical Alzheimer’s-type dementia (CATD) in individuals with suspected cognitive impairment; (2) the accuracy of biomarkers for identifying Alzheimer’s disease (AD) in individuals...

Keywords/Tags:
cognitive screening tests alzheimer's disease treatment

RPR User Guide

Research-to-Practice-to-Research (RPR) Exchange

If you need assistance with the RPR Exchange, please use the QOS form and leave a question or suggestion.  We review them regularly and will get back with you.  If you  need general information about using the RPR Exchange, the User Guide is available on-line.  You might also find the FAQs useful for some of the common questions RPR users have.