The treatment of breast cancer has evolved largely based on refinements in understanding of the biology of the disease and the variable risk for mortality among separate disease subtypes.1 Further, due to...
Recent Resources
Tapering Long-term Opioid Therapy in Chronic Noncancer Pain: Evidence and Recommendations for Everyday Practice
Increasing concern about the risks and limited evidence supporting the therapeutic benefit of long-term opioid therapy for chronic noncancer pain are leading prescribers to consider discontinuing the use of opioids. In addition to overt addiction or diversion, the presence of adverse effects,...
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Psyllium fiber improves glycemic control proportional to loss of glycemic control: a meta-analysis of data in euglycemic subjects, patients at risk of type 2 diabetes mellitus, and patients being treated for type 2 diabetes mellitus
BACKGROUND:
A number of health benefits are associated with intake of soluble, viscous, gel-forming fibers, including reduced serum cholesterol and the attenuation of postprandial glucose excursions.
OBJECTIVE:
We assess the effects of psyllium, which is a soluble, gel-...
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Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis
We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between...
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The 10 Building Blocks of High-Performing Primary Care
Our experiences studying exemplar primary care practices, and our work assisting other practices to become more patient centered, led to a formulation of the essential elements of primary care, which we call the 10 building blocks of high-performing primary care. The building blocks include 4...
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What Are Polygenic Scores and Why Are They Important?
Mendelian disorders and monogenic traits result from combinations of variants in 1 or a few genes that have a large effect on the propensity...
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Screening for Breast Cancer in Average-Risk Women: A Guidance Statement From the American College of Physicians
Description:
The purpose of this guidance statement is to provide advice to clinicians on breast cancer screening in average-risk women based on a review of existing guidelines and the evidence they include.
Methods:
This guidance statement is derived from an appraisal of...
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Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial
IMPORTANCE:
Sport-related concussion (SRC) is a significant public health problem without an effective treatment.
OBJECTIVE:
To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase...
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Adverse Effects of First-line Pharmacologic Treatments of Major Depression in Older Adults
Objective. To assess selected adverse events of antidepressants in the treatment of major depressive disorder (MDD) in adults 65 years old or older. Antidepressants included in this review, as determined by expert opinion, are selective serotonin reuptake inhibitors (SSRIs),...
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Terminating a Patient: Is It Time to Part Ways?
Many family physicians chose the specialty of family medicine because of the value placed on the therapeutic relationship between the patient and the physician. When that relationship is significantly or repeatedly challenged, family physicians feel it deeply, and it’s not always clear how best...
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