IMPORTANCE Major depressive disorder (MDD), a common mental disorder in the US, may
have substantial impact on the lives of affected individuals. If left untreated, MDD can
interfere with daily functioning and can also be associated with an increased risk of
cardiovascular...
Recent Resources
Screening for Depression and Suicide Risk in Adults US Preventive Services Task Force Recommendation Statement
Effects of Tai Chi and Qigong on cognitive and physical functions in older adults: systematic review, meta-analysis, and meta-regression of randomized clinical trials
Background: Older adults experience age-related declines in physical and cognitive functions due to interactions between aging and chronic diseases. Tai Chi and Qigong (TCQ) might be beneficial in improving the physical function and delaying the cognitive decline of this population. The...
Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity
Importance Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19 are key to assess population levels of protection and future needs for booster doses to face the resurgence of epidemic waves.
Objective To quantify the progressive waning of VE associated with the...
Diagnosis and management of depression in adolescents
Depression is common among adolescents in Canada and has the potential to negatively affect long-term function and quality of life; despite this, in most affected adolescents depression remains undetected and untreated.
Management requires a multimodal approach, including risk assessment...
Bedbugs
A resurgence in bedbugs is a result of increased travel and insecticide resistance
Many bedbug populations are resistant to pyrethroid, a chemical contained in most currently used insecticides.1 Bedbugs multiply exponentially, with thousands of bugs per infestation after 2–3 months.
Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes The GRADE Randomized Clinical Trial
Importance: Type 2 diabetes (T2D) is the leading cause of kidney disease in the US. It is not known whether glucose-lowering medications differentially affect kidney function.
Objective: To evaluate kidney outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative...
A pragmatic approach to the management of menopause
Menopause is defined as 1 year of amenorrhea caused by
declining ovarian reserve or as the onset of vasomotor
symptoms in people with iatrogenic amenorrhea. It is preceded
by perimenopause or the menopause transition, which can last
for as long as 10 years. Although many...
Recommendations on screening for primary prevention of fragility fractures
Background: Fragility fractures are a major health concern for older adults and can result in disability, admission to hospital and long-term care, and reduced quality of life. This Canadian Task Force on Preventive Health Care (task force) guideline provides evidence-based recommendations on...
What Is Narcolepsy?
Narcolepsy is a chronic disorder that causes excessive daytime sleepiness
and other symptoms that are due to abnormal rapid eye movement (REM) sleep.
Other signs and symptoms:
• Quick transitions into REM sleep
• Vivid dreams, hallucinations, and sleep paralysis
•...
Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment
Importance The association between statin-induced reduction in low-density lipoprotein cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than composite, outcomes, such as all-cause mortality, myocardial infarction, or stroke, is unclear.
Objective To...