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Drug Threat Bulletin: DSUVIA (Sufentanil)

Author/s: Oklahoma Bureau of Narcotics and Dangerous Drugs

The US Food and Drug Administration (FDA) approved DSUVIA, the synthetic opioid sufentanil in tiny blue tablet form, on Nov. 2, 2018 for single doses ingested under the tongue. Sufentanil is chemically similar to fentanyl (the lethal narcotic showing up as fake oxycodone pills and as a cutting...

Keywords/Tags:
DSUVIA opioids opioid-use disorder sufentanil

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

Author/s: Hayden, Frederick G., Sugaya, Norio, Hirotsu, Nobuo, Lee, Nelson, de Jong, Menno D., Hurt, Aeron C., Ishida, Tadashi, Sekino, Hisakuni, Yamada, Kota, Portsmouth, Simon, Kawaguchi, Keiko, Shishido, Takao, Arai, Masatsugu, Tsuchiya, Kenji, Uehara, Takeki, Watanabe, Akira, Baloxavir Marboxil Investigators Group

BACKGROUND:

Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.

METHODS:

We conducted two...

Keywords/Tags:
baloxavir marboxil oseltamivir influenza

Catheter Ablation of Atrial Fibrillation: An Overview for Clinicians

Author/s: Nebojša, Marinković, Milan, Lenarczyk, Radoslaw, Tilz, Roland, Potpara, Tatjana S.

Abstract

Catheter ablation (CA) of atrial fibrillation (AF) is currently one of the most commonly performed electrophysiology procedures. Ablation of paroxysmal AF is based on the elimination of triggers by pulmonary vein isolation (PVI), while different strategies for additional AF...

Keywords/Tags:
atrial fibrillation catheter ablation interventional cardiology pulmonary vein isolation stroke substrate modification

Pharmacologic Management of Newly Detected Atrial Fibrillation

Author/s: Frost, Jennifer L., Campos-Outcalt, Doug, Hoelting, David, LeFevre, Michael, Lin, Kenneth W., Vaughan, William, Bird, Melanie D.

Purpose
To review the evidence and provide clinical recommendations for the pharmacologic management of atrial fibrillation.
 

Methods
This guideline is based on two systematic reviews of published randomized controlled trials (RCTs) and...

Keywords/Tags:
atrial fibrillation pharmacologic management

FRAMES: The Essentials of a Brief Intervention for Problem Drinking Pocket Cards

Pocket cards of FRAMES: brief intervention for problem drinkers.
Keywords/Tags:
alcoholism drinking interventions alcohol

Diagnosis and Management of Nonalcoholic Liver Disease

Author/s: Paul, Sonali, Davis, Andrew M.

MAJOR RECOMMENDATIONS

• Patients with incidental hepatic steatosis detected on imaging who lack any liver-related symptoms or signs and have normal liver biochemistries should be assessed for metabolic risk factors (eg, obesity, diabetes mellitus, dyslipidemia) and other causes of hepatic...

Keywords/Tags:
non-alcoholic liver disease non-alcoholic fatty liver disease liver disease liver cirrhosis

Effectiveness of multicomponent programs with community mobilization for reducing alcohol-impaired driving

Author/s: Shults, Ruth A., Elder, Randy W., Nichols, David A., Compton, Richard, Chattopadhyay, Sajal K., Taskforce on Community Preventive Services

A systematic review was conducted to determine the effectiveness and economic efficiency of multicomponent programs with community mobilization for reducing alcohol-impaired driving. The review was conducted for the Guide to Community Preventive Services (Community Guide). Six studies of...

Keywords/Tags:
DUI driving under the influence community intervention community

Motivational Interviewing and Field Instruction: The FRAMES model

Author/s: Kamya, Hugo

Motivational interviewing is defined as a “client-centered, directive method for enhancing intrinsic motivation to change by exploring and resolving ambivalence” (Miller & Rollnick, 2002). In supervision of staff, the ultimate goal is to improve an organization’s efficiency by increasing...

Keywords/Tags:
motivational interviewing motivation burnout, professional compassion fatigue alcohol abuse alcoholism

Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial

Author/s: Gardner, Christopher G., Trepanowski, John F., Del Gobbo, Liana C., Hauser, Michelle E., Rigdon, Joseph, Ionnidis, John P. A., Desai, Manisha, King, Abby C.

Importance

Dietary modification remains key to successful weight loss. Yet, no one dietary strategy is consistently superior to others for the general population. Previous research suggests genotype or insulin-glucose dynamics may modify the effects of diets.

Objective

To...

Keywords/Tags:
diet weight loss

The Physical Activity Guidelines for Americans

Author/s: Piercy, Katrina L., Trioano, Richard P., Ballard, Rachel M., Carlson, Susan A., Fulton, Janet E., Galuska, Deborah A., George, Stephanie M., Olson, Richard D.

Importance  Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep better and reduce risk of many chronic diseases.

Objective  To...

Keywords/Tags:
physical activity lifestyle behaviors

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