Importance: The ELEKT-D: Electroconvulsive Therapy (ECT) vs Ketamine in Patients With Treatment Resistant Depression (TRD) (ELEKT-D) trial demonstrated noninferiority of intravenous ketamine vs ECT for nonpsychotic TRD. Clinical features that can guide selection of ketamine vs ECT may inform...
Library & Search Results
Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial
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Electronic Cigarettes vs Varenicline for Smoking Cessation in Adults: A Randomized Clinical Trial
Importance: Little is known about the relative effectiveness of nicotine-containing electronic cigarettes (ECs) compared with varenicline as smoking cessation aids.
Objective: To determine the relative effectiveness of ECs in smoking cessation.
Design, setting, and participants:...
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Olgotrelvir as a Single-Agent Treatment of Nonhospitalized Patients with Covid-19
Background: Olgotrelvir is an oral antiviral with dual mechanisms of action targeting severe acute respiratory syndrome coronavirus 2 main protease (i.e., Mpro) and human cathepsin L. It has potential to serve as a single-agent treatment of coronavirus disease 2019 (Covid-19).
Methods: We...
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The Women’s Health Initiative Randomized Trials and Clinical Practice
Importance: Approximately 55 million people in the US and approximately 1.1 billion people worldwide are postmenopausal women. To inform clinical practice about the health effects of menopausal hormone therapy, calcium plus vitamin D supplementation, and a low-fat dietary pattern, the Women's...
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Semaglutide vs Endoscopic Sleeve Gastroplasty for Weight Loss
Importance: Obesity is a disease with a large socioeconomic burden. Endoscopic sleeve gastroplasty (ESG) is a minimally invasive endoscopic bariatric procedure with wide global adoption. More recently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (eg,...
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Surveillance Colonoscopy Findings in Older Adults With a History of Colorectal Adenomas
Importance
Postpolypectomy surveillance is a common colonoscopy indication in older adults; however, guidelines provide little direction on when to stop surveillance in this population.
Objective
To estimate surveillance colonoscopy yields in older adults.
Design,...
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Omalizumab for the Treatment of Multiple Food Allergies
BACKGROUND
Food allergies are common and are associated with substantial morbidity; the only approved treatment is oral immunotherapy for peanut allergy.
METHODS
In this trial, we assessed whether omalizumab, a monoclonal anti-IgE antibody, would be effective and safe as...
ADHD Pharmacotherapy and Mortality in Individuals With ADHD
Importance: Attention-deficit/hyperactivity disorder (ADHD) is associated with increased risks of adverse health outcomes including premature death, but it is unclear whether ADHD pharmacotherapy influences the mortality risk.
Objective: To investigate whether initiation of ADHD...
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Age and Probability of Spontaneous Umbilical Hernia Closure
This cohort study of children younger than 6 years uses electronic health records to investigate whether a child’s age is associated with the probability of spontaneous umbilical hernia closure and to refine guidelines for surgical repair.
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Project nature: promoting outdoor physical activity in children via primary care
Background
Families face a range of barriers in supporting their children’s active play in nature including family circumstances, environmental constraints, and behavioral factors. Evidence-based strategies to address these barriers are needed. We aimed to develop and pilot test a primary...
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