Atopic dermatitis (AD) is a chronic inflammatory skin disease with persistent itching, which impairs quality of life (QoL). Although various conventional treatments for AD exist, patients with AD often seek complementary and alternative therapies when conventional therapy has failed to relieve...
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Infant pacifier sanitization and risk of challenge-proven food allergy: A cohort study
Background: Environmental microbial exposure plays a role in immune system development and susceptibility to food allergy.
Objective: We sought to investigate whether infant pacifier use during the first postnatal year, with further consideration of...
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The Key Role of Nonpharmacologic Management of Cachexia in Persons With Advanced Illness: A Teachable Moment
A man in his 80s with advanced colon cancer and malignant ascites presented to the oncology clinic to discuss next steps. He reported weight loss (approximately 15 kg in 2 months), and his daughter commented on his limited appetite, weakness, and that he was “just bones.” Recent computed...
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Get SET Early to Identify and Treatment Refer Autism Spectrum Disorder at 1 Year and Discover Factors That Influence Early Diagnosis
Objectives
To examine the impact of a new approach, Get SET Early, on the rates of early autism spectrum disorder (ASD) detection and factors that influence the screen-evaluate-treat chain.
Study design
Following Get SET Early training, 203 pediatricians...
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Trajectories of Opioid Use Following First Opioid Prescription in Opioid-Naive Youths and Young Adults
Importance: Although prescription opioids are the most common way adolescents and young adults initiate opioid use, many studies examine population-level risks following the first opioid prescription. There is currently a lack of understanding regarding how patterns of opioid...
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Non-steroidal anti-inflammatory drugs for acute low back pain
Background: Acute low back pain (LBP) is a common health problem. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used in the treatment of LBP, particularly in people with acute LBP. In 2008, a Cochrane Review was published about the efficacy of NSAIDs for LBP...
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Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians
Description: Antimicrobial overuse is a major health care issue that contributes to antibiotic resistance. Such overuse includes unnecessarily long durations of antibiotic therapy in patients with common bacterial infections, such as acute bronchitis with chronic obstructive...
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Safety and tolerability of natural and synthetic cannabinoids in adults aged over 50 years: A systematic review and meta-analysis
Background: Cannabinoid-based medicines (CBMs) are being used widely in the elderly. However, their safety and tolerability in older adults remains unclear. We aimed to conduct a systematic review and meta-analysis of safety and tolerability of CBMs in adults of age ≥50 years....
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Management of Persistent Pain in the Older Patient A Clinical Review
Importance: Persistent pain is highly prevalent, costly, and frequently disabling in later life.
Objective: To describe barriers to the management of persistent pain among older adults, summarize current management approaches, including pharmacologic and...
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Screening for Lung Cancer US Preventive Services Task Force Recommendation Statement
Importance: Lung cancer is the second most common cancer and the leading cause of cancer death in the US. In 2020, an estimated 228 820 persons were diagnosed with lung cancer, and 135 720 persons died of the disease. The most important risk factor for lung cancer is smoking....
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