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Neutropenia

Author/s: Mithoowani, Siraj, Cameron, L., Crowther, M. A.

»Neutropenia is seen in 5%–10% of healthy people
Based on absolute neutrophil count, neutropenia is commonly defined as
mild (1.0–1.5 × 109
/L), moderate (0.5–0.9 × 109
/L) or severe (< 0.5 × 109
/L).1
However, the reference interval is specific to the...

Keywords/Tags:
neutropenia complete blood count neutrophil count treatment Autoimmune Diseases

Review of systemic and syndromic complications of cannabis use: A review

Author/s: Shah, J., Fermo, O.

Purpose of review: Prescribed and non-prescribed cannabis use is common. Providers in specialties treating chronic pain – primary care, pain management, and neurology–will be coming across medical cannabis as a treatment for chronic pain, regardless of whether they are prescribers. It is...

Keywords/Tags:
neurology marijuana Pain managing pain complications of cannabis use

Chlorthalidone vs. Hydrochlorothiazide for Hypertension–Cardiovascular Events

Author/s: Ishani, A., Cushman, W. C., Leatherman, S. M., R. A., Woods, P., Glassman, P. A., Taylor, A. A., Hau, C., Klint, A., Huang, G. D., Brophy, M. T., Fiore, L. D., Ferguson, R. E., Diuretic Comparison Project Writing Group

Background: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear.

Methods: In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of...

Keywords/Tags:
hypertension cardiovascular events heart failure veterans infarction

Prescribing for common complications of spinal cord injury

Author/s: McColl, M. A., Gupta, S., McColl, A., Smith, K.

Objective: To describe prescribing patterns for 3 common complications associated with spinal cord injury (SCI) and to provide family doctors with strategies for optimizing the care of patients with SCI.

Sources of information: Results of a nationwide survey of prescription medication use...

Keywords/Tags:
Pain therapy Muscle spasticity spinal cord injuries common complications prescriptions

Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children

Author/s: Frost, H. M., Bizune, D., Gerber, J. S., Hersh, A. L., Hicks, L. A., Tsay, S. V.

Objectives: The objective of the study was to compare the antibiotic treatment failure and recurrence rates between antibiotic agents (amoxicillin, amoxicillin-clavulanate, cefdinir, and azithromycin) for children with uncomplicated acute otitis media (AOM).

Study design: We completed a...

Keywords/Tags:
Amoxicillin-Potassium Clavulanate Combination amoxicillin cefdinir Azithromycin acute otitis media

Individualized antidepressant therapy in patients with major depressive disorder: Novel evidence-informed decision support tool

Author/s: Chin, T., Huyghebaert, T., Svrcek, C., Oluboka, O.

Objective: To introduce a visual clinical decision support tool to assist with individualizing first-line antidepressant pharmacotherapy for adults with major depressive disorder (MDD) in a Canadian context.

Sources of information: A literature review was conducted with Google Scholar,...

Keywords/Tags:
Systematic Reviews as Topic antidepressive agents Serotonin Uptake Inhibitors Major Depressive Disorder SSRI

Health benefits of physical activity: the evidence

Author/s: Warburton, D. E. R., Nicol, C. W., Bredin, S. S. D.

The primary purpose of this narrative review was to evaluate the current literature and to provide further insight into the role physical inactivity plays in the development of chronic disease and premature death. We confirm that there is irrefutable evidence of the effectiveness of regular...

Keywords/Tags:
Health Behavior exercise Health Status Chronic Disease physical activity

Long-Term Health Outcomes in Obstructive Sleep Apnea: A Systematic Review of Comparative Studies Evaluating Positive Airway Pressure and the Validity of Breathing Measures as Surrogate Outcomes

Author/s: Balk, E. M., Adam, G. P., Cao, W., Bhuma, M. R., Forbes, S., Mehta, S., Panagiotou, O., D'Ambrosio, C., Trikalinos, T. A.

Background. Obstructive sleep apnea (OSA) is a disorder characterized by periods of airflow
cessation (apnea) or reduced airflow (hypopnea) during sleep. The diagnosis and severity of
OSA, and response to therapy, have historically been assessed using the apnea-hypopnea index
(...

Keywords/Tags:
CPAP Obstructive sleep apnea sleep apnea systematic review breathing measures

Cost-effectiveness of management strategies in recurrent acute otitis media

Author/s: Noorbakhsh, K. A., Liu, H., Kurs-Lasky, M., Smith, K. J., Hoberman, A., Shakh, N.

Objective: To evaluate the cost-effectiveness of tympanostomy tube placement vs. nonsurgical medical management, with the option of tympanostomy tube placement in the event of treatment failure, in children with recurrent acute otitis media (AOM).

Study design: A Markov decision model...

Keywords/Tags:
Recurrent acute otitis media ear infections Tympanostomy tube placement nonsurgical medical management acute otitis media

Alcohol Use Disorder and Alcohol-Associated Liver Disease

Author/s: Ramissoon, R., Shah, V. H.

This article is part of a Festschrift commemorating the 50th anniversary of the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the National Institute of Mental Health and later as an independent institute of the National Institutes of Health,...

Keywords/Tags:
alcoholism liver diseases alcoholism complications alcoholism diagnosis alcohol misuse

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