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Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)

Author/s: Agarwal, Anup, Mukherjee, Aparna, Kumar, Gunjan, Chatterjee, Pranab, Bharnagar, Tarun, Malhotra, Pankaj

Abstract

Objective To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India.

Design Open label, parallel arm, phase II, multicentre, randomised controlled trial.

...

Keywords/Tags:
COVID-19 coronavirus plasma antibody testing convalescent plasma

Medical Care of Adults With Down Syndrome: A Clinical Guideline

Author/s: Tsou, Amy Y., Bulova, Peter, Capone, George, Chicoine, Brian, Global Down Syndrome Foundation Medical Care Guidelines for Adults with Down Syndrome Workgroup

Abstract

Importance: Down syndrome is the most common chromosomal condition, and average life expectancy has increased substantially, from 25 years in 1983 to 60 years in 2020. Despite the unique clinical comorbidities among adults with Down syndrome, there are no...

Lung Cancer Screening with Low-Dose CT: a Meta-Analysis

Author/s: Hoffman, Richard M., Atallah, Rami P., Struble, Roger D., Badgett, Robert G

Background: Randomized controlled trials have evaluated the efficacy of low-dose CT (LDCT) lung cancer screening on lung cancer (LC) outcomes.

Objective: Meta-analyze LDCT lung cancer screening trials.

Methods: We identified...

Keywords/Tags:
low-dose computed tomography lung cancer screening lung neoplasms meta-analysis mortality

Management of Colonic Diverticulitis

Author/s: Balk, E.M., Adam, G.P., Cao, W., Bhuma, M.R., Mehta, S., Saldanha, Saldanha, I.J., Beland, M.D., Shah, N.

Not available
Keywords/Tags:
Diverticulitis Colonic diseases treatment diagnosis

Life Expectancy after Bariatric Surgery in the Swedish Obese Subjects Study

Author/s: Carlsson, Lena M.S., Sjöholm, Kajsa, Jacobson, Peter, Andersson-Assarsson, Johanna C., Svensson, Per-Arne, Taube, Magdalena, Carlsson, Björn, Peltonen, Markku

BACKGROUND

Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.

METHODS

We used the Gompertz proportional hazards regression model to compare mortality and life expectancy...

Keywords/Tags:
Life expectancy obesity bariatric surgery

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2020 Recommendations of the International Antiviral Society–USA Panel

Author/s: Saag, Michael S., Gandhi, Rajesh T., Hoy, Jennifer F., Landovitz, Raphael J., Thompson, Melanie A., Sax, Paul E., Smith, Savey M., Benson, Constance A., Buchbinder, Susan P., Del Rio, Carlos, Eron Jr., Joseph J., Fätkenheuer, Gerd, Günthard, Huldrych F., Molina, Jean-Michel, Jacobsen, Donna M., Volberding, Paul A.

Importance  Data on the use of antiretroviral drugs, including new drugs and formulations, for the treatment and prevention of HIV infection continue to guide optimal practices.

Objective  To evaluate new data and incorporate them into current...

Keywords/Tags:
antiretroviral drugs HIV disease COVID-19

Antibiotic Choice and Clinical Outcomes in Ambulatory Children with Community-Acquired Pneumonia

Author/s: Lipsett, Susan C., Hall, Matthew, Ambroggio, Lilliam, Hersh, Adam L., Shah, Samir S., Brogan, Thomas V., Gerber, Jeffrey S., Williams, Derek J., Grijalva, Carlos G., Blaschke, Anne J., Neuman, Mark I.

Objectives

To describe antibiotic prescribing patterns in ambulatory children with community acquired pneumonia, and to assess the relationship between antibiotic selection and clinical outcomes.

Study design

This was a retrospective cohort study of ambulatory Medicaid-...

Keywords/Tags:
antibiotic stewardship outcomes research macrolides complex chronic condition

Influenza Vaccine for 2020-2021

Author/s: American Medical Association

Not available. 
Keywords/Tags:
influenza vaccine

Ensuring Patient Protections When Tapering Opioids: Consensus Panel Recommendations

Author/s: Covington, Edward C, Argoff, Charles E, Ballantyne, Jane C, Cowan, Penney, Gazelka, Halena M, Kertesz, Stefan G, Manhapra, Ajay, Murphy, Jennifer L, Stanos, Steven P Jr., Sullivan, Mark D

Long-term opioid therapy has the potential for serious adverse outcomes and is often used in a vulnerable population. Because adverse effects or failure to maintain benefits is common with long-term use, opioid taper or discontinuation may be indicated in certain patients. Concerns about the...

Keywords/Tags:
opioids Opioid-Related Disorders opioid therapy long-term care

Risk of COVID-19 During Air Travel

Author/s: Pombal, Rui, Hosegood, Ian, Powell, David

Not available.

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