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https://www.rpr.lib.ok.us/taxonomy/term/9743/all
enNirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections
https://www.rpr.lib.ok.us/resource/nirmatrelvir-or-molnupiravir-use-and-severe-outcomes-omicron-infections
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-10-04T00:00:00-05:00">October 4, 2023</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">JAMA Network Open</div>
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<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
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<div class="field-item even">AMA</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-09-21T00:00:00-05:00">September 21, 2023</span></div>
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<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
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<div class="field-item even">9</div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">6</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=100123%3Fadv%3D000003220113" target="_blank">Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1001/jamanetworkopen.2023.35077</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/ritonavir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Ritonavir</a></div>
<div class="field-item even"><a href="/tags/molnupiravir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Molnupiravir</a></div>
<div class="field-item odd"><a href="/tags/covid-19-variants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 variants</a></div>
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<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">37733342</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-vaccines" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines</a></div>
<div class="field-item even"><a href="/mesh/covid-19-drug-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Drug Treatment</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>High risk outpatients with COVID (omicron type) appear to benefit from either molnupiravir or nirmatrelvir. James W. Mold, MD, MPH</p>
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<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
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<div class="field-item even">Free full text</div>
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<a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=100123%3Fadv%3D000003220113" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p>Question: What outcomes are associated with ritonavir-boosted nirmatrelvir or molnupiravir use for outpatient treatment of SARS-CoV-2 Omicron subvariants, particularly BQ.1.1 and XBB.1.5, in high-risk individuals?</p>
<p>Findings: In a cohort study of 68 867 patients who received a diagnosis of COVID-19 at Cleveland Clinic from April 1, 2022, to February 20, 2023, and who were at high risk of progressing to severe COVID-19, both nirmatrelvir and molnupiravir use were significantly associated with reductions in hospitalization and death. The association was observed across subgroups defined by age, race and ethnicity, date of diagnosis, vaccination status, previous infection status, and coexisting conditions.</p>
<p>Meaning: These findings suggest that both nirmatrelvir and molnupiravir can be used to treat nonhospitalized patients who are at high risk of progressing to severe COVID-19.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Lin, Dan-Yu, Huang, Shuaiqi, Abi Fadel, Francois</div>
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Wed, 04 Oct 2023 05:00:00 +0000Rowan Hutchins2119 at https://www.rpr.lib.ok.us