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https://www.rpr.lib.ok.us/taxonomy/term/8961/all
enAmoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children
https://www.rpr.lib.ok.us/resource/amoxicillin-versus-other-antibiotic-agents-treatment-acute-otitis-media-children
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2022-12-11T00:00:00-06:00">December 11, 2022</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">The Journal of Pediatrics</div>
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<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
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<div class="field-item even">Elsevier</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2022-08-06T00:00:00-05:00">August 6, 2022</span></div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">251</div>
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<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
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<div class="field-item even">98-105</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://www.jpeds.com/article/S0022-3476(22)00674-6/fulltext?dgcid=raven_jbs_etoc_email" target="_blank">Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1016/j.jpeds.2022.07.053</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/amoxicillin-potassium-clavulanate-combination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Amoxicillin-Potassium Clavulanate Combination</a></div>
<div class="field-item odd"><a href="/tags/amoxicillin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">amoxicillin</a></div>
<div class="field-item even"><a href="/tags/cefdinir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cefdinir</a></div>
<div class="field-item odd"><a href="/tags/azithromycin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Azithromycin</a></div>
<div class="field-item even"><a href="/tags/acute-otitis-media" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">acute otitis media</a></div>
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<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">35944719</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/otitis-media-drug-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Otitis Media* / drug therapy</a></div>
<div class="field-item odd"><a href="/mesh/amoxicillin-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Amoxicillin* / therapeutic use</a></div>
<div class="field-item even"><a href="/mesh/anti-bacterial-agents-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Anti-bacterial Agents / therapeutic use</a></div>
<div class="field-item odd"><a href="/mesh/cefdinir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cefdinir</a></div>
<div class="field-item even"><a href="/mesh/azithromycin-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Azithromycin / therapeutic use</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>This retrospective cohort study reaffirms that acute otitis almost always resolves and that amoxicillin is as good or better than other antibiotics for treatment, when treatment is deemed necessary. James W. Mold, MD, MPH</p>
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<div class="field-item even">Free full text</div>
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<a href="https://www.jpeds.com/article/S0022-3476(22)00674-6/fulltext?dgcid=raven_jbs_etoc_email" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p>Objectives: The objective of the study was to compare the antibiotic treatment failure and recurrence rates between antibiotic agents (amoxicillin, amoxicillin-clavulanate, cefdinir, and azithromycin) for children with uncomplicated acute otitis media (AOM).</p>
<p>Study design: We completed a retrospective cohort study of children 6 months-12 years of age with uncomplicated AOM identified in a nationwide claims database. The primary exposure was the antibiotic agent, and the primary outcomes were treatment failure and recurrence. Logistic regression was used to estimate ORs, and analyses were stratified by primary exposure, patient age, and antibiotic duration.</p>
<p>Results: Among the 1 051 007 children included in the analysis, 56.6% were prescribed amoxicillin, 13.5% were prescribed amoxicillin-clavulanate, 20.6% were prescribed cefdinir, and 9.3% were prescribed azithromycin. Most prescriptions (93%) were for 10 days, and 98% were filled within 1 day of the medical encounter. Treatment failure and recurrence occurred in 2.2% (95% CI: 2.1, 2.2) and 3.3% (3.2, 3.3) of children, respectively. Combined failure and recurrence rates were low for all agents including amoxicillin (1.7%; 1.7, 1.8), amoxicillin-clavulanate (11.3%; 11.1, 11.5), cefdinir (10.0%; 9.8, 10.1), and azithromycin (9.8%; 9.6, 10.0).</p>
<p>Conclusions: Despite microbiologic changes in AOM etiology, treatment failure and recurrence were uncommon for all antibiotic agents and were lower for amoxicillin than for other agents. These findings support the continued use of amoxicillin as a first-line agent for AOM when antibiotics are prescribed.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Frost, H. M., Bizune, D., Gerber, J. S., Hersh, A. L., Hicks, L. A., Tsay, S. V.</div>
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Sun, 11 Dec 2022 06:00:00 +0000Aubrey Delammermore1939 at https://www.rpr.lib.ok.us