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https://www.rpr.lib.ok.us/taxonomy/term/8112/all en https://www.rpr.lib.ok.us/resource/treat-or-not-treat-effect-urate-lowering-therapy-renal-function-blood-pressure-and-safety <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2022-05-10T00:00:00-05:00">May 10, 2022</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Journal of the American Board of Family Medicine </div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">Journal of the American Board of Family Medicine</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2022-01-16T00:00:00-06:00">January 16, 2022</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">1</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">35</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">140-151</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.jabfm.org/content/35/1/140" target="_blank">To Treat or Not to Treat? Effect of Urate-Lowering Therapy on Renal Function, Blood Pressure and Safety in Patients with Asymptomatic Hyperuricemia: A Systematic Review and Network Meta-Analysis</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.3122/jabfm.2022.01.210273</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/asymptomatic-hyperuricemia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Asymptomatic Hyperuricemia</a></div> <div class="field-item odd"><a href="/tags/blood-pressure" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">blood pressure</a></div> <div class="field-item even"><a href="/tags/disease-management" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Disease Management</a></div> <div class="field-item odd"><a href="/tags/family-medicine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">family medicine</a></div> <div class="field-item even"><a href="/tags/network-meta-analysis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Network Meta-Analysis</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">35039419</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/united-states" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">United States</a></div> <div class="field-item odd"><a href="/mesh/uric-acid" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Uric Acid</a></div> <div class="field-item even"><a href="/mesh/febuxostat" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Febuxostat</a></div> <div class="field-item odd"><a href="/mesh/allopurinol" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Allopurinol</a></div> <div class="field-item even"><a href="/mesh/benzbromarone" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Benzbromarone</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>Lowering uric acid levels in patients with asymptomatic hyperuricemia appears to have beneficial effects on renal function and/or blood pressure, depending upon the medication used, with very few significant adverse effects. James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-2a78b3a23760eb5d21f4acc78fbd9d7d"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.jabfm.org/content/35/1/140" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Purpose: Hyperuricemia is associated with increased cardiovascular risk. Because patients with asymptomatic hyperuricemia (AH) experience no immediate discomfort and there are possible side effects of urate-lowering drugs, treatment for AH is controversial. We aimed to perform a network meta-analysis (NMA) to investigate the effects of different urate-lowering therapies (ULTs) on serum uric acid level, renal function, blood pressure (BP), and safety in AH patients.</p> <p>Methods: This NMA focused on AH patients. The intervention group (patients receiving urate-lowering drugs) was compared with others using other types of drugs, placebo, or usual care. We undertook a NMA under the frequentist framework by R.</p> <p>Results: Thirteen eligible trials were identified. The interventions included allopurinol, febuxostat, and benzbromarone, which are not approved in the United States. Benzbromarone and allopurinol had the best efficacy on lowering serum uric acid level in short-term and long-term follow-up (mean difference [MD] = -3.05; 95% CI, -5.19 to -0.91 vs MD = -3.17; 95% CI, -5.19 to -1.15). Patients using allopurinol had significantly higher eGFR than using placebo in both short-term and long-term follow-up (MD = 3.07; 95% CI, 0.18 to 5.95 vs MD = 4.10; 95% CI, 2.66 to 5.54). No difference in BP was found between groups, except for febuxostat to diastolic BP after long-term treatment (MD = -1.47; 95% CI, -2.91 to -0.04). No statistically increased odds of safety events were found with the use of ULT.</p> <p>Conclusions: Our result showed that in AH patients, allopurinol has a renoprotective effect. Febuxostat has a significant impact in lowering diastolic BP. ULT does not result in a higher risk of safety events.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Tien, Y., Shih, M., Tien, C., Huang, H., Tu, Y.</div> </div> </div> Tue, 10 May 2022 05:00:00 +0000 Saige Blanchard 1790 at https://www.rpr.lib.ok.us