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https://www.rpr.lib.ok.us/taxonomy/term/7674/all en https://www.rpr.lib.ok.us/resource/efficacy-and-safety-nonantibiotic-outpatient-treatment-mild-acute-diverticulitis-dinamo <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2021-11-02T00:00:00-05:00">November 2, 2021</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Annals of Surgery</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2021-11-01T00:00:00-05:00">November 1, 2021</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">5</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">274</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">e435-e442</div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1097/SLA.0000000000005031</div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">34183510</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div> <div class="field-item odd"><a href="/mesh/amoxicillin-potassium-clavulanate-combination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Amoxicillin-potassium clavulanate combination</a></div> <div class="field-item even"><a href="/mesh/anti-bacterial-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">anti-bacterial agents</a></div> <div class="field-item odd"><a href="/mesh/prospective-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">prospective studies</a></div> <div class="field-item even"><a href="/mesh/outpatients" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">outpatients</a></div> <div class="field-item odd"><a href="/mesh/anti-inflammatory-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Anti-Inflammatory Agents</a></div> <div class="field-item even"><a href="/mesh/ambulatory-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Ambulatory Care</a></div> <div class="field-item odd"><a href="/mesh/hospitalization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hospitalization</a></div> <div class="field-item even"><a href="/mesh/pain-management" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pain management</a></div> <div class="field-item odd"><a href="/mesh/emergency-service-hospital" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Emergency Service, hospital</a></div> <div class="field-item even"><a href="/mesh/hospitals" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hospitals</a></div> <div class="field-item odd"><a href="/mesh/tomography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tomography</a></div> <div class="field-item even"><a href="/mesh/pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pain</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>Apparently it isn’t necessary to treat patients with mild diverticulitis with antibiotics.</p> </div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-0937e24cb9b9995a59ae8bd569b9f807"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://journals.lww.com/annalsofsurgery/Fulltext/2021/11000/Efficacy_and_Safety_of_Nonantibiotic_Outpatient.37.aspx" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Objective:<br /> Mild AD can be treated safely and effectively on an outpatient basis without antibiotics.</p> <p>Summary of Background Data:<br /> In recent years, it has shown no benefit of antibiotics in the treatment of uncomplicated AD in hospitalized patients. Also, outpatient treatment of uncomplicated AD has been shown to be safe and effective.</p> <p>Methods:<br /> A Prospective, multicentre, open-label, noninferiority, randomized controlled trial, in 15 hospitals of patients consulting the emergency department with symptoms compatible with AD.</p> <p>The Participants were patients with mild AD diagnosed by Computed Tomography meeting the inclusion criteria were randomly assigned to control arm (ATB-Group): classical treatment (875/125 mg/8 h amoxicillin/clavulanic acid apart from anti-inflammatory and symptomatic treatment) or experimental arm (Non-ATB-Group): experimental treatment (antiinflammatory and symptomatic treatment). Clinical controls were performed at 2, 7, 30, and 90 days.</p> <p>The primary endpoint was hospital admission. Secondary endpoints included number of emergency department revisits, pain control and emergency surgery in the different arms.</p> <p>Results:<br /> Four hundred and eighty patients meeting the inclusion criteria were randomly assigned to Non-ATB-Group (n = 242) or ATB-Group (n = 238). Hospitalization rates were: ATB-Group 14/238 (5.8%) and Non-ATB-Group 8/242 (3.3%) [mean difference 2.58%, 95% confidence interval (CI) 6.32 to -1.17], confirming noninferiority margin. Revisits: ATB-Group 16/238 (6.7%) and Non-ATB-Group 17/242 (7%) (mean difference -0.3, 95% CI 4.22 to -4.83). Poor pain control at 2 days follow up: ATB-Group 13/230 (5.7%), Non-ATB-Group 5/221 (2.3%) (mean difference 3.39, 95% CI 6.96 to -0.18).</p> <p>Conclusions:<br /> Nonantibiotic outpatient treatment of mild AD is safe and effective and is not inferior to current standard treatment.</p> <p>Trial registration:<br /> ClinicalTrials.gov (NCT02785549); EU Clinical Trials Register (2016-001596-75)</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Mora-López, L., Ruiz-Edo, N., Estrada-Ferrer, O., Piñana-Campón, M. L., Labró-Ciurans, M., Escuder-Perez, J., Sales-Mallafré, R., Rebasa-Cladera, P., Navarro-Soto, S., Serra-Aracil, X.</div> </div> </div> Tue, 02 Nov 2021 05:00:00 +0000 Bethie Seay 1698 at https://www.rpr.lib.ok.us