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Deprecated: Return type of DrupalCacheArray::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 388 Diabetic Retinopathy
https://www.rpr.lib.ok.us/taxonomy/term/6723/all
enThe relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus
https://www.rpr.lib.ok.us/resource/relationship-between-exacerbated-diabetic-peripheral-neuropathy-and-metformin-treatment
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2021-03-03T00:00:00-06:00">March 3, 2021</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">Scientific Reports</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2021-01-21T00:00:00-06:00">January 21, 2021</span></div>
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<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
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<div class="field-item even">11</div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">1</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/33479439/" target="_blank">The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1038/s41598-021-81631-8</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/diabetes-type-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diabetes, type 2</a></div>
<div class="field-item odd"><a href="/tags/metformin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">metformin</a></div>
<div class="field-item even"><a href="/tags/insulin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">insulin</a></div>
<div class="field-item odd"><a href="/tags/metformin-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Metformin Treatment</a></div>
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<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">33479439</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/metformin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Metformin</a></div>
<div class="field-item odd"><a href="/mesh/diabetic-neuropathies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diabetic neuropathies</a></div>
<div class="field-item even"><a href="/mesh/nad" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">NAD</a></div>
<div class="field-item odd"><a href="/mesh/diabetic-retinopathy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Diabetic Retinopathy</a></div>
<div class="field-item even"><a href="/mesh/insulin-secretion" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Insulin Secretion</a></div>
<div class="field-item odd"><a href="/mesh/diabetes-mellitus" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diabetes mellitus</a></div>
<div class="field-item even"><a href="/mesh/type-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Type 2</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>This study suggests that prolonged treatment with metformin is associated with reduced Vitamin B12 levels and an increased incidence of distal peripheral neuropathy. James W. Mold, MD, MPH</p>
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<div class="field-item even">Free full text</div>
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<a href="https://pubmed.ncbi.nlm.nih.gov/33479439/" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p>Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN). This study aimed to determine whether or not metformin is a risk factor for DPN. We compared MTD to non-metformin-treated diabetics (NMTD) clinically using the Toronto Clinical Scoring System (TCSS), laboratory (methylmalonic acid, cobalamin, and homocysteine), and electrophysiological studies. Median homocysteine and methylmalonic acid levels in MTD vs. NMTD were 15.3 vs. 9.6 µmol/l; P < 0.001 and 0.25 vs. 0.13 µmol/l; P = 0.02, respectively with high statistical significance in MTD. There was a significantly lower plasma level of cobalamin in MTD than NMTD. Spearman's correlation showed a significant negative correlation between cobalamin and increased dose of metformin and a significant positive correlation between TCSS and increased dose of metformin. Logistic regression analysis showed that MTD had significantly longer metformin use duration, higher metformin dose > 2 g, higher TCSS, lower plasma cobalamin, and significant higher homocysteine. Diabetics treated with metformin for prolonged duration and higher doses were associated with lower cobalamin and more severe DPN.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Hashem, Manal Mohammed, Esmael, Ahmed, Nassar, Abdelfattah Kasem, El-Sherif, Mohammed</div>
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Wed, 03 Mar 2021 06:00:00 +0000Devin Evans1510 at https://www.rpr.lib.ok.us