Deprecated : Return type of DrupalCacheArray::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 362 Deprecated : Return type of DrupalCacheArray::offsetGet($offset) should either be compatible with ArrayAccess::offsetGet(mixed $offset): mixed, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 369 Deprecated : Return type of DrupalCacheArray::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 381 Deprecated : Return type of DrupalCacheArray::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 388
mass screening
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Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-11-12T00:00:00-06:00">November 12, 2020</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">Annals of Family Medicine</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-11-01T00:00:00-05:00">November 1, 2020</span></div>
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<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
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<div class="field-item even">6</div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">18</div>
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<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
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<div class="field-item even">545-552</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/33168683/" target="_blank">Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">https://doi.org/10.1370/afm.2582</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/cancer-screening" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cancer screening</a></div>
<div class="field-item odd"><a href="/tags/health-services" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">health services</a></div>
<div class="field-item even"><a href="/tags/low-dose-computed-tomography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">low-dose computed tomography</a></div>
<div class="field-item odd"><a href="/tags/lung-cancer" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">lung cancer</a></div>
<div class="field-item even"><a href="/tags/mass-screening" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mass screening</a></div>
<div class="field-item odd"><a href="/tags/overdiagnosis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">overdiagnosis</a></div>
<div class="field-item even"><a href="/tags/preventive-medicine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">preventive medicine</a></div>
<div class="field-item odd"><a href="/tags/public-health" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">public health</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>An unbiased meta-analysis documenting that screening with low-dose CT reduces lung cancer mortality with a 20% rate of overdiagnoses. The number needed to screen to prevent one lung cancer death is 294. However, there is as yet no conclusive evidence that it reduces all-cause mortality. James W. Mold, MD, MPH</p>
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<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
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<div class="field-item even">Free full text</div>
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<a href="https://pubmed.ncbi.nlm.nih.gov/33168683/" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field field-name-body field-type-text-with-summary field-label-hidden">
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<div class="field-item even" property="content:encoded"><p>Abstract</p>
<p><strong>Purpose: </strong>Benefit of lung cancer screening using low-dose computed tomography (LDCT) in reducing lung cancer-specific and all-cause mortality is unclear. We undertook a meta-analysis to assess its associations with outcomes.</p>
<p><strong>Methods: </strong>We searched the literature and previous systematic reviews to identify randomized controlled trials comparing LDCT screening with usual care or chest radiography. We performed meta-analysis using a random effects model. The primary outcomes were lung cancer-specific mortality, all-cause mortality, and the cumulative incidence ratio of lung cancer between screened and unscreened groups as a measure of overdiagnosis.</p>
<p><strong>Results: </strong>Meta-analysis was based on 8 trials with 90,475 patients that had a low risk of bias. There was a significant reduction in lung cancer-specific mortality with LDCT screening (relative risk = 0.81; 95% CI, 0.74-0.89); the estimated absolute risk reduction was 0.4% (number needed to screen = 250). The reduction in all-cause mortality was not statistically significant (relative risk = 0.96; 95% CI, 0.92-1.01), but the absolute reduction was consistent with that for lung cancer-specific mortality (0.34%; number needed to screen = 294). In the studies with the longest duration of follow-up, the incidence of lung cancer was 25% higher in the screened group, corresponding to a 20% rate of overdiagnosis.</p>
<p><strong>Conclusions: </strong>This meta-analysis showing a significant reduction in lung cancer-specific mortality, albeit with a tradeoff of likely overdiagnosis, supports recommendations to screen individuals at elevated risk for lung cancer with LDCT.</p>
<p><strong>Keywords: </strong>cancer screening; health services; low-dose computed tomography; lung cancer; mass screening; overdiagnosis; preventive medicine; public health.</p>
<p>© 2020 Annals of Family Medicine, Inc.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Ebell, M.H., Bentivegna, M., Hulme, C.</div>
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Thu, 12 Nov 2020 16:45:00 +0000
Brian Desmarais
1380 at https://www.rpr.lib.ok.us