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https://www.rpr.lib.ok.us/taxonomy/term/5973/all
enConvalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)
https://www.rpr.lib.ok.us/resource/convalescent-plasma-management-moderate-covid-19-adults-india-open-label-phase-ii
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-10-28T00:00:00-05:00">October 28, 2020</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">British Medical Journal</div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-10-22T00:00:00-05:00">October 22, 2020</span></div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/33093056/" target="_blank">Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1136/bmj.m3939</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/coronavirus" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">coronavirus</a></div>
<div class="field-item even"><a href="/tags/plasma" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">plasma</a></div>
<div class="field-item odd"><a href="/tags/antibody-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">antibody testing</a></div>
<div class="field-item even"><a href="/tags/convalescent-plasma" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">convalescent plasma</a></div>
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<div class="field-label">PMID (1): </div>
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<div class="field-item even">33093056</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/coronavirus" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Coronavirus</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/mesh/antibodies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antibodies</a></div>
<div class="field-item odd"><a href="/mesh/neutralizing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Neutralizing</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>Based upon this RCT, once a COVID-19 patient is hospitalized, treatment with convalescent plasma apparently has little effect on outcomes. James W. Mold, MD, MPH</p>
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<div class="field-item even">Free full text</div>
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<a href="https://pubmed.ncbi.nlm.nih.gov/33093056/" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p>Abstract</p>
<p><strong>Objective</strong> To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India.</p>
<p><strong>Design</strong> Open label, parallel arm, phase II, multicentre, randomised controlled trial.</p>
<p><strong>Setting</strong> 39 public and private hospitals across India.</p>
<p><strong>Participants</strong> 464 adults (≥18 years) admitted to hospital (screened 22 April to 14 July 2020) with confirmed moderate covid-19 (partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO2/FiO2) ratio between 200 mm Hg and 300 mm Hg or a respiratory rate of more than 24/min with oxygen saturation 93% or less on room air): 235 were assigned to convalescent plasma with best standard of care (intervention arm) and 229 to best standard of care only (control arm).</p>
<p><strong>Interventions</strong> Participants in the intervention arm received two doses of 200 mL convalescent plasma, transfused 24 hours apart. The presence and levels of neutralising antibodies were not measured a priori; stored samples were assayed at the end of the study.</p>
<p><strong>Main outcome measure</strong> Composite of progression to severe disease (PaO2/FiO2 <100 mm Hg) or all cause mortality at 28 days post-enrolment.</p>
<p><strong>Results</strong> Progression to severe disease or all cause mortality at 28 days after enrolment occurred in 44 (19%) participants in the intervention arm and 41 (18%) in the control arm (risk difference 0.008 (95% confidence interval −0.062 to 0.078); risk ratio 1.04, 95% confidence interval 0.71 to 1.54).</p>
<p><strong>Conclusion</strong> Convalescent plasma was not associated with a reduction in progression to severe covid-19 or all cause mortality. This trial has high generalisability and approximates convalescent plasma use in real life settings with limited laboratory capacity. A priori measurement of neutralising antibody titres in donors and participants might further clarify the role of convalescent plasma in the management of covid-19.</p>
<p><strong>Trial registration</strong> Clinical Trial Registry of India CTRI/2020/04/024775.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
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<div class="field-item even">Agarwal, Anup, Mukherjee, Aparna, Kumar, Gunjan, Chatterjee, Pranab, Bharnagar, Tarun, Malhotra, Pankaj</div>
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Wed, 28 Oct 2020 05:00:00 +0000Devin Evans1350 at https://www.rpr.lib.ok.us