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https://www.rpr.lib.ok.us/taxonomy/term/5039/all
enEfficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial
https://www.rpr.lib.ok.us/resource/efficacy-intra-articular-hypertonic-dextrose-prolotherapy-knee-osteoarthritis-randomized
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-05-13T00:00:00-05:00">May 13, 2020</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">Annals of Family Medicine</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-05-01T00:00:00-05:00">May 1, 2020</span></div>
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<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
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<div class="field-item even">3</div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">18</div>
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<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
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<div class="field-item even">235-242</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/32393559/?from_single_result=Ef%20cacy%20of%20Intra-Articular%20Hypertonic%20Dextrose%20%28Prolotherapy%29%20for%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Controlled%20Trial&expanded_search_query=Ef%20cacy%20of%20Intra-Articular%20Hypertonic%20Dextrose%20%28Prolotherapy%29%20for%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Controlled%20Trial" target="_blank">Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1370/afm.2520</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/prolotherapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Prolotherapy</a></div>
<div class="field-item odd"><a href="/mesh/osteoarthritis-knee" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">osteoarthritis, knee</a></div>
<div class="field-item even"><a href="/mesh/saline-solution" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Saline Solution</a></div>
<div class="field-item odd"><a href="/mesh/quality-life" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">quality of life</a></div>
<div class="field-item even"><a href="/mesh/visual-analog-scale" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Visual Analog Scale</a></div>
<div class="field-item odd"><a href="/mesh/personal-satisfaction" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Personal Satisfaction</a></div>
<div class="field-item even"><a href="/mesh/glucose" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">glucose</a></div>
<div class="field-item odd"><a href="/mesh/universities" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Universities</a></div>
<div class="field-item even"><a href="/mesh/ontario" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Ontario</a></div>
<div class="field-item odd"><a href="/mesh/random-allocation" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">random allocation</a></div>
<div class="field-item even"><a href="/mesh/hong-kong" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hong Kong</a></div>
<div class="field-item odd"><a href="/mesh/injections" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Injections</a></div>
<div class="field-item even"><a href="/mesh/intra-articular" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Intra-Articular</a></div>
<div class="field-item odd"><a href="/mesh/knee-pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Knee Pain</a></div>
<div class="field-item even"><a href="/mesh/knee" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Knee</a></div>
<div class="field-item odd"><a href="/mesh/joint-pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Joint Pain</a></div>
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<div class="field-item even"><p>In this relatively small RCT, prolotherapy was more effective than saline injections for relieving pain and improving function in patients with OA of the knee at 4, 6, and 12 months. James W. Mold, MD, MPH</p>
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<div class="field-item even">Commercial full text (fees may apply)</div>
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<a href="https://pubmed.ncbi.nlm.nih.gov/32393559/?from_single_result=Ef%20cacy%20of%20Intra-Articular%20Hypertonic%20Dextrose%20%28Prolotherapy%29%20for%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Controlled%20Trial&expanded_search_query=Ef%20cacy%20of%20Intra-Articular%20Hypertonic%20Dextrose%20%28Prolotherapy%29%20for%20Knee%20Osteoarthritis%3A%20A%20Randomized%20Controlled%20Trial" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p> </p>
<p><strong>Purpose: </strong>To test the efficacy of intra-articular hypertonic dextrose prolotherapy (DPT) vs normal saline (NS) injection for knee osteoarthritis (KOA).</p>
<p><strong>Methods: </strong>A single-center, parallel-group, blinded, randomized controlled trial was conducted at a university primary care clinic in Hong Kong. Patients with KOA (n = 76) were randomly allocated (1:1) to DPT or NS groups for injections at weeks 0, 4, 8, and 16. The primary outcome was the Western Ontario McMaster University Osteoarthritis Index (WOMAC; 0-100 points) pain score. The secondary outcomes were the WOMAC composite, function and stiffness scores; objectively assessed physical function test results; visual analogue scale (VAS) for knee pain; and EuroQol-5D score. All outcomes were evaluated at baseline and at 16, 26, and 52 weeks using linear mixed model.</p>
<p><strong>Results: </strong>Randomization produced similar groups. The WOMAC pain score at 52 weeks showed a difference-in-difference estimate of -10.34 (95% CI, -19.20 to -1.49, <em>P</em> = 0.022) points. A similar favorable effect was shown on the difference-in-difference estimate on WOMAC function score of -9.55 (95% CI, -17.72 to -1.39, <em>P</em> = 0.022), WOMAC composite score of -9.65 (95% CI, -17.77 to -1.53, <em>P</em> = 0.020), VAS pain intensity score of -10.98 (95% CI, -21.36 to -0.61, <em>P</em> = 0.038), and EuroQol-5D VAS score of 8.64 (95% CI, 1.36 to 5.92, <em>P</em> = 0.020). No adverse events were reported.</p>
<p><strong>Conclusion: </strong>Intra-articular dextrose prolotherapy injections reduced pain, improved function and quality of life in patients with KOA compared with blinded saline injections. The procedure is straightforward and safe; the adherence and satisfaction were high.</p>
<p><strong>Keywords: </strong>intra-articular hypertonic dextrose; knee osteoarthritis; normal saline; prolotherapy; randomized clinical trial.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Sit, R.W.S., Wu, R.W., Reeves, K.D., Chan, D.C.C., Yip, B.H.K., Chung, V.C.H., Wong, S.</div>
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Wed, 13 May 2020 23:54:05 +0000Brian Desmarais1144 at https://www.rpr.lib.ok.us