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https://www.rpr.lib.ok.us/taxonomy/term/4250/all
enAntiviral Therapies for Adults with Mild to Moderate COVID-19 Infection
https://www.rpr.lib.ok.us/resource/antiviral-therapies-adults-mild-moderate-covid-19-infection
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-06-30T00:00:00-05:00">June 30, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">The American Medical Association</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-06-30T00:00:00-05:00">June 30, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
<div class="field-items">
<div class="field-item even">E1-E2</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://jamanetwork.com/journals/jama/fullarticle/2850813?guestAccessKey=55527155-2e66-4e78-8f8f-a49db45f4a45&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=063026" target="_blank">Antiviral Therapies for Adults with Mild to Moderate COVID-19 Infection</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">doi: 10.1001/jama.2026.6918</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/antiviral" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/antiviral-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">antiviral agents</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>RPR Commentary: 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America (IDSA) on the Treatment and Management of COVID-19: Antiviral Treatment for Mild to Moderate COVID-19 in Adults. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-a78741dd8581b866988d2e4c03e79563">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://jamanetwork.com/journals/jama/fullarticle/2850813?guestAccessKey=55527155-2e66-4e78-8f8f-a49db45f4a45&utm_medium=email&utm_source=postup_jn&utm_campaign=article_alert-jama&utm_content=olf-tfl_&utm_term=063026" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>With increasing population immunity through vaccination and prior infection, the risk of severe COVID-19, hospitalization, and death has substantially decreased in all age groups in the US since 2021.1 However, certain populations, especially those aged 65 years or older, remain at increased risk for progression to severe disease. This updated guideline provides a risk-stratified approach to antiviral therapies for patients with mild to moderate COVID-19 (defined as symptoms of respiratory infection with oxygen saturation >94% while breathing room air). Antiviral therapies are most effective when initiated within 5 to 7 days of COVID-19 symptom onset.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Kristen M. Marks, Andrew M. Davis</div>
</div>
</div>
Tue, 30 Jun 2026 21:39:53 +0000Nathan Hinkle3027 at https://www.rpr.lib.ok.usUpdated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026
https://www.rpr.lib.ok.us/resource/updated-evidence-covid-19-rsv-and-influenza-vaccines-2025%E2%80%932026
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-12-11T00:00:00-06:00">December 11, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">New England Journal of Medicine</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-10-29T00:00:00-05:00">October 29, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/41160817/" target="_blank">Updated Evidence for Covid-19, RSV, and Influenza Vaccines for 2025–2026</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1056/NEJMsa2514268</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19-vaccine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 vaccine</a></div>
<div class="field-item odd"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/tags/vaccination-0" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">'Vaccination</a></div>
<div class="field-item odd"><a href="/tags/vaccines" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">vaccines</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">41160817</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19-vaccines-administration-dosage" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines* / administration & dosage</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-vaccines-adverse-effects" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines* / adverse effects</a></div>
<div class="field-item even"><a href="/mesh/covid-19-vaccines-immunology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines* / immunology</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
<div class="field-item even"><a href="/mesh/covid-19-prevention-control" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / prevention & control</a></div>
<div class="field-item odd"><a href="/mesh/guillain-barre-syndrome-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Guillain-Barre Syndrome / epidemiology</a></div>
<div class="field-item even"><a href="/mesh/hospitalization-statistics-numerical-data" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hospitalization / statistics & numerical data</a></div>
<div class="field-item odd"><a href="/mesh/vaccine-efficacy-statistics-numerical-data" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Vaccine Efficacy* / statistics & numerical data</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>An updated summary of the effectiveness data for influenza, COVID, and RSV vaccines. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-936417bca46caad50f8acdd73fe594d9">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/41160817/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Background: Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunization for respiratory viruses during the 2025-2026 season.</p>
<p>Methods: We conducted a systematic review of U.S.-licensed immunizations against coronavirus disease 2019 (Covid-19), respiratory syncytial virus (RSV), and influenza. We searched databases on PubMed/MEDLINE, Embase, and Web of Science for updates of the most recent review by the Advisory Committee on Immunization Practices (ACIP) Evidence-to-Recommendations for each disease, which was performed during the 2023-2024 period. Outcomes included vaccine efficacy and effectiveness against hospitalization, other clinical end points, and safety.</p>
<p>Results: Of 17,263 identified references, 511 studies met the inclusion criteria. Covid-19 mRNA vaccines against the XBB.1.5 subvariant had pooled vaccine effectiveness against hospitalization of 46% (95% confidence interval [CI], 34 to 55; from cohort studies) and 50% (95% CI, 43 to 57; from case-control studies) among adults and 37% (95% CI, 29 to 44) among immunocompromised adults. In a case-control study, vaccines against the KP.2 subvariant showed an effectiveness of 68% (95% CI, 42 to 82). Maternal RSV vaccination (for infant protection), nirsevimab for infants, and RSV vaccines in adults who were 60 years of age or older showed vaccine effectiveness of 68% or more against hospitalization. Influenza vaccination had a pooled vaccine effectiveness of 48% (95% CI, 39 to 55) in adults between the ages of 18 and 64 years and 67% (95% CI, 58 to 75) in children against hospitalization. Safety profiles were consistent with previous evaluations. The diagnosis of myocarditis associated with Covid-19 vaccines occurred at rates of 1.3 to 3.1 per 100,000 doses in male adolescents, with lower risk associated with longer dosing intervals. The RSVpreF vaccine was associated with 18.2 excess cases of Guillain-Barré syndrome per million doses in older adults; a significant association with preterm birth was not observed when the vaccine was administered at 32 to 36 weeks' gestation.</p>
<p>Conclusions: Ongoing peer-reviewed evidence supports the safety and effectiveness of immunizations against Covid-19, RSV, and influenza during the 2025-2026 season. (Funded by the Center for Infectious Disease Research and Policy and the Alumbra Innovations Foundation.).</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Michael S. Abers, Jake Scott, Harleen K. Marwah, Nicole C. McCann, Eric A. Meyerowitz, Aaron Richterman, Derek F. Fleming, Caitlin M. Dugdale</div>
</div>
</div>
Thu, 11 Dec 2025 22:01:49 +0000Megan George2843 at https://www.rpr.lib.ok.usThe 2024 National Academies of Sciences, Engineering, and Medicine Long COVID Definition: What Clinicians Need to Know
https://www.rpr.lib.ok.us/resource/2024-national-academies-sciences-engineering-and-medicine-long-covid-definition-what
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-08-06T00:00:00-05:00">August 6, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of General Internal Medicine</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-03-10T00:00:00-05:00">March 10, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/40063321/" target="_blank">The 2024 National Academies of Sciences, Engineering, and Medicine Long COVID Definition: What Clinicians Need to Know</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Public Health Announcements</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1007/s11606-025-09415-8</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/long-covid" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Long COVID</a></div>
<div class="field-item even"><a href="/tags/post-acute-sequelae-covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">post-acute sequelae of COVID-19</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">40063321</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-complications" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / complications</a></div>
<div class="field-item even"><a href="/mesh/covid-19-diagnosis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / diagnosis</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / therapy</a></div>
<div class="field-item even"><a href="/mesh/chronic-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">chronic disease</a></div>
<div class="field-item odd"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div>
<div class="field-item even"><a href="/mesh/national-academies-science" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">National Academies of Science</a></div>
<div class="field-item odd"><a href="/mesh/engineering" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Engineering</a></div>
<div class="field-item even"><a href="/mesh/and-medicine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">and Medicine</a></div>
<div class="field-item odd"><a href="/mesh/us" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">U.S.</a></div>
<div class="field-item even"><a href="/mesh/health-and-medicine-division-0" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Health and Medicine Division*</a></div>
<div class="field-item odd"><a href="/mesh/post-acute-covid-19-syndrome" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">post-acute COVID-19 syndrome</a></div>
<div class="field-item even"><a href="/mesh/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
<div class="field-item odd"><a href="/mesh/united-statesepidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">United States/epidemiology</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>A definition of long-COVID from the National Academy of Medicine. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-b2f48a2a41a2283d350fc39f1a99ea42">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/40063321/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Millions of Americans affected by Long COVID (LC) report difficulty accessing care and support. One barrier is obtaining a diagnosis. In response, US federal agencies commissioned a National Academies of Sciences, Engineering, and Medicine (NASEM) committee to re-examine the existing federal definitions for LC. The Committee concluded that LC is "an infection-associated chronic condition (IACC) occurring after SARS-CoV-2 infection that is present for at least 3 months as a continuous, relapsing and remitting, or progressive disease state that can present as singular or multiple symptoms and/or diagnosable conditions." The full report was released in June 2024. We briefly highlight features and aspects of the definition that may help clinicians identify those who remain undiagnosed and improve care for all LC patients.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Lily Chu, Karyn Bishof, Abigail A Dumes, E Wesley Ely, Paule V Joseph, Andrea B Troxel</div>
</div>
</div>
Wed, 06 Aug 2025 22:16:16 +0000Megan George2721 at https://www.rpr.lib.ok.usLong COVID in Young Children, School-Aged Children, and Teens
https://www.rpr.lib.ok.us/resource/long-covid-young-children-school-aged-children-and-teens
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-07-08T00:00:00-05:00">July 8, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA Pediatrics</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-05-27T00:00:00-05:00">May 27, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/40423990/" target="_blank">Long COVID in Young Children, School-Aged Children, and Teens</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Patient Education Materials</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jamapediatrics.2025.1415</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/children" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">children</a></div>
<div class="field-item even"><a href="/tags/long-covid" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Long COVID</a></div>
<div class="field-item odd"><a href="/tags/long-covid-syndrome" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Long COVID Syndrome</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">40423990</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/post-acute-covid-19-syndrome" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">post-acute COVID-19 syndrome</a></div>
<div class="field-item odd"><a href="/mesh/child" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">child</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Information for parents about Long COVID Syndrome in children. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-8c068f4e427bee900ff28eac18284f22">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/40423990/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>This JAMA Pediatrics Patient Page describes the symptoms of long COVID in children.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Rachel S Gross, Megan Carmilani, Melissa S Stockwell</div>
</div>
</div>
Tue, 08 Jul 2025 16:31:55 +0000Hope Smashey2693 at https://www.rpr.lib.ok.usAn Evidence-Based Approach to Covid-19 Vaccination
https://www.rpr.lib.ok.us/resource/evidence-based-approach-covid-19-vaccination
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-05-27T00:00:00-05:00">May 27, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">NEJM</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-05-20T00:00:00-05:00">May 20, 2025</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/40392534/" target="_blank">An Evidence-Based Approach to Covid-19 Vaccination</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1056/NEJMsb2506929</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/vaccination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">vaccination</a></div>
<div class="field-item even"><a href="/tags/policy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Policy</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">40392534</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/mesh/vaccination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">vaccination</a></div>
<div class="field-item even"><a href="/mesh/policy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Policy</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>An evidence-based review and recommendations regarding COVID vaccination. James W. Mold, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-f07f3b041a02f3bbc1252b101052de01">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/40392534/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>No abstract available.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Vinay Prasad, Martin A Makary</div>
</div>
</div>
Tue, 27 May 2025 13:16:39 +0000Alex Haga2649 at https://www.rpr.lib.ok.usPersonal protective effect of wearing surgical face masks in public spaces on self-reported respiratory symptoms in adults: pragmatic randomised superiority trial
https://www.rpr.lib.ok.us/resource/personal-protective-effect-wearing-surgical-face-masks-public-spaces-self-reported
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-08-26T00:00:00-05:00">August 26, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">BMJ</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">BMJ Publishing Group</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-07-24T00:00:00-05:00">July 24, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">386</div>
</div>
</div>
<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
<div class="field-items">
<div class="field-item even">e078918</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/39048132/" target="_blank">Personal protective effect of wearing surgical face masks in public spaces on self-reported respiratory symptoms in adults: pragmatic randomised superiority trial</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1136/bmj-2023-078918</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/betacoronavirus" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Betacoronavirus</a></div>
<div class="field-item odd"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/tags/masks" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">masks</a></div>
<div class="field-item odd"><a href="/tags/face-masks" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">face masks</a></div>
<div class="field-item even"><a href="/tags/respiratory-tract-infections" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">respiratory tract infections</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">39048132</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/betacoronavirus" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Betacoronavirus</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/mesh/masks" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">masks</a></div>
<div class="field-item odd"><a href="/mesh/respiratory-tract-infections" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">respiratory tract infections</a></div>
<div class="field-item even"><a href="/mesh/coronavirus-infections" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Coronavirus Infections</a></div>
<div class="field-item odd"><a href="/mesh/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Advising high-risk patients to wear facial masks when out in public appears to make some sense. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-80defe007a809be569ed5953169ac428">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/39048132/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Objective: To evaluate the personal protective effects of wearing versus not wearing surgical face masks in public spaces on self-reported respiratory symptoms over a 14 day period.</p>
<p>Design: Pragmatic randomised superiority trial.</p>
<p>Setting: Norway.</p>
<p>Participants: 4647 adults aged ≥18 years: 2371 were assigned to the intervention arm and 2276 to the control arm.</p>
<p>Interventions: Participants in the intervention arm were assigned to wear a surgical face mask in public spaces (eg, shopping centres, streets, public transport) over a 14 day period (mask wearing at home or work was not mentioned). Participants in the control arm were assigned to not wear a surgical face mask in public places.</p>
<p>Main outcome measures: The primary outcome was self-reported respiratory symptoms consistent with a respiratory infection. Secondary outcomes included self-reported and registered covid-19 infection.</p>
<p>Results: Between 10 February 2023 and 27 April 2023, 4647 participants were randomised of whom 4575 (2788 women (60.9%); mean age 51.0 (standard deviation 15.0) years) were included in the intention-to-treat analysis: 2313 (50.6%) in the intervention arm and 2262 (49.4%) in the control arm. 163 events (8.9%) of self-reported symptoms consistent with respiratory infection were reported in the intervention arm and 239 (12.2%) in the control arm. The marginal odds ratio was 0.71 (95% confidence interval (CI) 0.58 to 0.87; P=0.001) favouring the face mask intervention. The absolute risk difference was -3.2% (95% CI -5.2% to -1.3%; P<0.001). No statistically significant effect was found on self- reported (marginal odds ratio 1.07, 95% CI 0.58 to 1.98; P=0.82) or registered covid-19 infection (effect estimate and 95% CI not estimable owing to lack of events in the intervention arm).</p>
<p>Conclusion: Wearing a surgical face mask in public spaces over 14 days reduces the risk of self-reported symptoms consistent with a respiratory infection, compared with not wearing a surgical face mask.</p>
<p>Trial registration: ClinicalTrials.gov NCT05690516.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Runar Barstad Solberg, Atle Fretheim, Ingeborg Hess Elgersma, Mette Fagernes, Bjørn Gunnar Iversen, Lars G Hemkens, Christopher James Rose, Petter Elstrøm</div>
</div>
</div>
Mon, 26 Aug 2024 15:29:19 +0000Erin Blanchette2393 at https://www.rpr.lib.ok.usOlgotrelvir as a Single-Agent Treatment of Nonhospitalized Patients with Covid-19
https://www.rpr.lib.ok.us/resource/olgotrelvir-single-agent-treatment-nonhospitalized-patients-covid-19
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-06-16T00:00:00-05:00">June 16, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">NEJM Evidence</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-05-28T00:00:00-05:00">May 28, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">6</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">3</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/38804790/" target="_blank">Olgotrelvir as a Single-Agent Treatment of Nonhospitalized Patients with Covid-19</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1056/EVIDoa2400026</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/antiviral" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral</a></div>
<div class="field-item even"><a href="/tags/oral" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">oral</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">38804790</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-drug-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Drug Treatment</a></div>
<div class="field-item even"><a href="/mesh/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
<div class="field-item odd"><a href="/mesh/antiviral-agents-administration-dosage" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral Agents* / administration & dosage</a></div>
<div class="field-item even"><a href="/mesh/antiviral-agents-adverse-effects" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral Agents* / adverse effects</a></div>
<div class="field-item odd"><a href="/mesh/antiviral-agents-therapeutic-use-0" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral Agents* / therapeutic use</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Olgotrelvir (Ovydso) is an oral antiviral that can reduce the severity and duration of COVID-19 infections in outpatients. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-9557c5e3d38972b2b1c70a98ab54b48c">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/38804790/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Background: Olgotrelvir is an oral antiviral with dual mechanisms of action targeting severe acute respiratory syndrome coronavirus 2 main protease (i.e., Mpro) and human cathepsin L. It has potential to serve as a single-agent treatment of coronavirus disease 2019 (Covid-19).</p>
<p>Methods: We conducted a phase 3, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of olgotrelvir in 1212 nonhospitalized adult participants with mild to moderate Covid-19, irrespective of risk factors, who were randomly assigned to receive orally either 600 mg of olgotrelvir or placebo twice daily for 5 days. The primary and key secondary end points were time to sustained recovery of a panel of 11 Covid-19-related symptoms and the viral ribonucleic acid (RNA) load. The safety end point was incidence of treatment-emergent adverse events.</p>
<p>Results: The baseline characteristics of 1212 participants were similar in the two groups. In the modified intention-to-treat population (567 patients in the placebo group and 558 in the olgotrelvir group), the median time to symptom recovery was 205 hours in the olgotrelvir group versus 264 hours in the placebo group (hazard ratio, 1.29; 95% confidence interval [CI], 1.13 to 1.46; P<0.001). The least squares mean (95% CI) changes of viral RNA load from baseline were -2.20 (-2.59 to -1.81) log10 copies/ml in olgotrelvir-treated participants and -1.40 (-1.79 to -1.01) in participants receiving placebo at day 4. Skin rash (3.3%) and nausea (1.5%) were more frequent in the olgotrelvir group than in the placebo group; there were no treatment-related serious adverse events, and no deaths were reported.</p>
<p>Conclusions: Olgotrelvir as a single-agent treatment significantly improved symptom recovery. Adverse effects were not dose limiting. (Funded by Sorrento Therapeutics, a parent company of ACEA Therapeutics; ClinicalTrials.gov number, NCT05716425.).</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Rongmeng Jiang, Bing Han, Wanhong Xu, Xiaoying Zhang, Chunxian Peng, Qiang Dang, Wei Sun, Ling Lin</div>
</div>
</div>
Sun, 16 Jun 2024 18:56:52 +0000Alex Haga2331 at https://www.rpr.lib.ok.usTilt Table Testing
https://www.rpr.lib.ok.us/resource/tilt-table-testing-0
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-04-23T00:00:00-05:00">April 23, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-04-11T00:00:00-05:00">April 11, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/38602671/" target="_blank">Tilt Table Testing</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jama.2024.0004</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/tilt-table-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tilt table testing</a></div>
<div class="field-item odd"><a href="/tags/syncope" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">syncope</a></div>
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/dyspnea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dyspnea</a></div>
<div class="field-item even"><a href="/tags/electrocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">electrocardiography</a></div>
<div class="field-item odd"><a href="/tags/echocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Echocardiography</a></div>
<div class="field-item even"><a href="/tags/tilt-table" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tilt table</a></div>
<div class="field-item odd"><a href="/tags/physical-examination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Physical Examination</a></div>
<div class="field-item even"><a href="/tags/cardiac-catheterization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiac Catheterization</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">38602671</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/hydrocortisone" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hydrocortisone</a></div>
<div class="field-item odd"><a href="/mesh/methacholine-chloride" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Methacholine Chloride</a></div>
<div class="field-item even"><a href="/mesh/bronchoscopy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Bronchoscopy</a></div>
<div class="field-item odd"><a href="/mesh/dizziness" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dizziness</a></div>
<div class="field-item even"><a href="/mesh/oxygen-saturation" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Oxygen Saturation</a></div>
<div class="field-item odd"><a href="/mesh/sitting-position" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">sitting position</a></div>
<div class="field-item even"><a href="/mesh/walk-test" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Walk Test</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/mesh/dyspnea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dyspnea</a></div>
<div class="field-item odd"><a href="/mesh/electrocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Electrocardiography</a></div>
<div class="field-item even"><a href="/mesh/echocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Echocardiography</a></div>
<div class="field-item odd"><a href="/mesh/physical-examination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Physical Examination</a></div>
<div class="field-item even"><a href="/mesh/cardiac-catheterization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiac Catheterization</a></div>
<div class="field-item odd"><a href="/mesh/fatigue" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">fatigue</a></div>
<div class="field-item even"><a href="/mesh/blood-cell-count" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">blood cell count</a></div>
<div class="field-item odd"><a href="/mesh/thyrotropin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Thyrotropin</a></div>
<div class="field-item even"><a href="/mesh/chest-pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Chest Pain</a></div>
<div class="field-item odd"><a href="/mesh/tomography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tomography</a></div>
<div class="field-item even"><a href="/mesh/nausea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Nausea</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>A summary and example of how to use tilt table testing in patients with syncope and various other fairly common symptoms. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Commercial full text (fees may apply)</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-cb32f781b9022e10c5e09b16b3b2ca67">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/38602671/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>A 43-year-old woman presented with a 1-year history of recurring symptoms of sudden onset of fatigue, palpitations, dyspnea, chest pain, lightheadedness, and nausea that were associated with standing and resolved with sitting. These symptoms began 1 month after mild COVID-19 infection. At presentation, while supine, blood pressure (BP) was 123/70 mm Hg and heart rate (HR) was 90/min; while seated, BP was 120/80 and HR was 93/min; after standing for 1 minute, BP was 124/80 and HR was 119/min. Physical examination results were normal. Oxygen saturation was 98% at rest while breathing room air. She had no oxygen desaturation during a 6-minute walk test but walked only 282 m (45% predicted). Complete blood cell count, morning cortisol, and thyrotropin blood levels were normal. Electrocardiogram (ECG), chest computed tomography, pulmonary function testing, methacholine challenge, bronchoscopy, echocardiography, and cardiac catheterization findings were normal. During tilt table testing, the patient experienced lightheadedness and nausea when moved from horizontal to the upright position. Results of the tilt table test are shown in the Table and Figure.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Chesire, W.P., Dudenkov, D.V., Munipalli, B.</div>
</div>
</div>
Tue, 23 Apr 2024 17:41:24 +0000Alex Haga2279 at https://www.rpr.lib.ok.usTilt Table Testing
https://www.rpr.lib.ok.us/resource/tilt-table-testing
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-04-23T00:00:00-05:00">April 23, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-04-11T00:00:00-05:00">April 11, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/38602671/" target="_blank">Tilt Table Testing</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jama.2024.0004</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/tilt-table-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tilt table testing</a></div>
<div class="field-item odd"><a href="/tags/syncope" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">syncope</a></div>
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/dyspnea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dyspnea</a></div>
<div class="field-item even"><a href="/tags/electrocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">electrocardiography</a></div>
<div class="field-item odd"><a href="/tags/echocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Echocardiography</a></div>
<div class="field-item even"><a href="/tags/tilt-table" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tilt table</a></div>
<div class="field-item odd"><a href="/tags/physical-examination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Physical Examination</a></div>
<div class="field-item even"><a href="/tags/cardiac-catheterization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiac Catheterization</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">38602671</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/hydrocortisone" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hydrocortisone</a></div>
<div class="field-item odd"><a href="/mesh/methacholine-chloride" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Methacholine Chloride</a></div>
<div class="field-item even"><a href="/mesh/bronchoscopy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Bronchoscopy</a></div>
<div class="field-item odd"><a href="/mesh/dizziness" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dizziness</a></div>
<div class="field-item even"><a href="/mesh/oxygen-saturation" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Oxygen Saturation</a></div>
<div class="field-item odd"><a href="/mesh/sitting-position" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">sitting position</a></div>
<div class="field-item even"><a href="/mesh/walk-test" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Walk Test</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/mesh/dyspnea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dyspnea</a></div>
<div class="field-item odd"><a href="/mesh/electrocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Electrocardiography</a></div>
<div class="field-item even"><a href="/mesh/echocardiography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Echocardiography</a></div>
<div class="field-item odd"><a href="/mesh/physical-examination" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Physical Examination</a></div>
<div class="field-item even"><a href="/mesh/cardiac-catheterization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiac Catheterization</a></div>
<div class="field-item odd"><a href="/mesh/fatigue" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">fatigue</a></div>
<div class="field-item even"><a href="/mesh/blood-cell-count" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">blood cell count</a></div>
<div class="field-item odd"><a href="/mesh/thyrotropin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Thyrotropin</a></div>
<div class="field-item even"><a href="/mesh/chest-pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Chest Pain</a></div>
<div class="field-item odd"><a href="/mesh/tomography" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">tomography</a></div>
<div class="field-item even"><a href="/mesh/nausea" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Nausea</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>A summary and example of how to use tilt table testing in patients with syncope and various other fairly common symptoms. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Commercial full text (fees may apply)</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-5fbf513eda8e2a576bd4130b26a09b84">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/38602671/" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>A 43-year-old woman presented with a 1-year history of recurring symptoms of sudden onset of fatigue, palpitations, dyspnea, chest pain, lightheadedness, and nausea that were associated with standing and resolved with sitting. These symptoms began 1 month after mild COVID-19 infection. At presentation, while supine, blood pressure (BP) was 123/70 mm Hg and heart rate (HR) was 90/min; while seated, BP was 120/80 and HR was 93/min; after standing for 1 minute, BP was 124/80 and HR was 119/min. Physical examination results were normal. Oxygen saturation was 98% at rest while breathing room air. She had no oxygen desaturation during a 6-minute walk test but walked only 282 m (45% predicted). Complete blood cell count, morning cortisol, and thyrotropin blood levels were normal. Electrocardiogram (ECG), chest computed tomography, pulmonary function testing, methacholine challenge, bronchoscopy, echocardiography, and cardiac catheterization findings were normal. During tilt table testing, the patient experienced lightheadedness and nausea when moved from horizontal to the upright position. Results of the tilt table test are shown in the Table and Figure.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Chesire, W.P., Dudenkov, D.V., Munipalli, B.</div>
</div>
</div>
Tue, 23 Apr 2024 17:40:59 +0000Alex Haga2277 at https://www.rpr.lib.ok.usOutpatient randomized controlled trials to reduce COVID-19 hospitalization: Systematic review and meta-analysis
https://www.rpr.lib.ok.us/resource/outpatient-randomized-controlled-trials-reduce-covid-19-hospitalization-systematic-review
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-01-18T00:00:00-06:00">January 18, 2024</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of Medical Virology</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Wiley Online Library</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-12-17T00:00:00-06:00">December 17, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">12</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">95</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/38105461/" target="_blank">Outpatient randomized controlled trials to reduce COVID-19 hospitalization: Systematic review and meta-analysis</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1002/jmv.29310</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/convalescent-plasma" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">convalescent plasma</a></div>
<div class="field-item even"><a href="/tags/monoclonal-antibody" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">monoclonal antibody</a></div>
<div class="field-item odd"><a href="/tags/outpatients" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">outpatients</a></div>
<div class="field-item even"><a href="/tags/randomized-controlled-trial" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">randomized controlled trial</a></div>
<div class="field-item odd"><a href="/tags/small-molecule-antivirals" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">small molecule antivirals</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">38105461</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/antibodies-monoclonal-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antibodies, Monoclonal / therapeutic use</a></div>
<div class="field-item odd"><a href="/mesh/antiviral-agents-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiviral Agents / therapeutic use</a></div>
<div class="field-item even"><a href="/mesh/covid-19-serotherapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Serotherapy</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / therapy</a></div>
<div class="field-item even"><a href="/mesh/outpatients" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">outpatients</a></div>
<div class="field-item odd"><a href="/mesh/randomized-controlled-trials-topic" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Randomized Controlled Trials as Topic</a></div>
<div class="field-item even"><a href="/mesh/hospitalization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hospitalization</a></div>
<div class="field-item odd"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>A comparison of the impact of various treatments for COVID-19 on rates of hospitalizations. Figure 5 provides the best summary. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
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</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-92f8acff3d6bf71c0ddf89264b6e1324">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://onlinelibrary.wiley.com/doi/10.1002/jmv.29310" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>This COVID-19 outpatient randomized controlled trials (RCTs) systematic review compares hospitalization outcomes amongst four treatment classes over pandemic period, geography, variants, and vaccine status. Outpatient RCTs with hospitalization endpoint were identified in Pubmed searches through May 2023, excluding RCTs <30 participants (PROSPERO-CRD42022369181). Risk of bias was extracted from COVID-19-NMA, with odds ratio utilized for pooled comparison. Searches identified 281 studies with 61 published RCTs for 33 diverse interventions analyzed. RCTs were largely unvaccinated cohorts with at least one COVID-19 hospitalization risk factor. Grouping by class, monoclonal antibodies (mAbs) (OR = 0.31 [95% CI = 0.24-0.40]) had highest hospital reduction efficacy, followed by COVID-19 convalescent plasma (CCP) (OR = 0.69 [95% CI = 0.53-0.90]), small molecule antivirals (OR = 0.78 [95% CI = 0.48-1.33]), and repurposed drugs (OR = 0.82 [95% CI: 0.72-0.93]). Earlier in disease onset interventions performed better than later. This meta-analysis allows approximate head-to-head comparisons of diverse outpatient interventions. Omicron sublineages (XBB and BQ.1.1) are resistant to mAbs Despite trial heterogeneity, this pooled comparison by intervention class indicated oral antivirals are the preferred outpatient treatment where available, but intravenous interventions from convalescent plasma to remdesivir are also effective and necessary in constrained medical resource settings or for acute and chronic COVID-19 in the immunocompromised.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Daniele Focosi, David J. Sullivan, Daniel F. Hanley, Mario Cruciani, Massimo Franchini, Jiangda Ou, Arturo Casadevall, Nigel Paneth</div>
</div>
</div>
Thu, 18 Jan 2024 18:39:33 +0000Linda Fowler2203 at https://www.rpr.lib.ok.usNirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections
https://www.rpr.lib.ok.us/resource/nirmatrelvir-or-molnupiravir-use-and-severe-outcomes-omicron-infections
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-10-04T00:00:00-05:00">October 4, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA Network Open</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">AMA</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-09-21T00:00:00-05:00">September 21, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">9</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">6</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=100123%3Fadv%3D000003220113" target="_blank">Nirmatrelvir or Molnupiravir Use and Severe Outcomes From Omicron Infections</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jamanetworkopen.2023.35077</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/ritonavir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Ritonavir</a></div>
<div class="field-item even"><a href="/tags/molnupiravir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Molnupiravir</a></div>
<div class="field-item odd"><a href="/tags/covid-19-variants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 variants</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">37733342</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-vaccines" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines</a></div>
<div class="field-item even"><a href="/mesh/covid-19-drug-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Drug Treatment</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>High risk outpatients with COVID (omicron type) appear to benefit from either molnupiravir or nirmatrelvir. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-8e733a5d95e78d8a7bcee6e095072beb">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2809779?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=100123%3Fadv%3D000003220113" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Question: What outcomes are associated with ritonavir-boosted nirmatrelvir or molnupiravir use for outpatient treatment of SARS-CoV-2 Omicron subvariants, particularly BQ.1.1 and XBB.1.5, in high-risk individuals?</p>
<p>Findings: In a cohort study of 68 867 patients who received a diagnosis of COVID-19 at Cleveland Clinic from April 1, 2022, to February 20, 2023, and who were at high risk of progressing to severe COVID-19, both nirmatrelvir and molnupiravir use were significantly associated with reductions in hospitalization and death. The association was observed across subgroups defined by age, race and ethnicity, date of diagnosis, vaccination status, previous infection status, and coexisting conditions.</p>
<p>Meaning: These findings suggest that both nirmatrelvir and molnupiravir can be used to treat nonhospitalized patients who are at high risk of progressing to severe COVID-19.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Lin, Dan-Yu, Huang, Shuaiqi, Abi Fadel, Francois</div>
</div>
</div>
Wed, 04 Oct 2023 05:00:00 +0000Rowan Hutchins2119 at https://www.rpr.lib.ok.usOutpatient Treatment for COVID-19
https://www.rpr.lib.ok.us/resource/outpatient-treatment-covid-19
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-09-27T00:00:00-05:00">September 27, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">AMA</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-08-16T00:00:00-05:00">August 16, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://jamanetwork.com/journals/jama/fullarticle/2808687?guestAccessKey=3ef6c699-3c89-4843-9008-03433769bb45&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=081623&adv=000003220113" target="_blank">Outpatient Treatment for COVID-19</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Patient Education Materials</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jama.2023.16666</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/outpatient" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">outpatient</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">37585210</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
<div class="field-item odd"><a href="/mesh/outpatients" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">outpatients</a></div>
<div class="field-item even"><a href="/mesh/ritonavir" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Ritonavir</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Information for patients about outpatient treatment options for COVID-19. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-17785850a5a79aec832881cbc29c3f24">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://jamanetwork.com/journals/jama/fullarticle/2808687?guestAccessKey=3ef6c699-3c89-4843-9008-03433769bb45&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=081623&adv=000003220113" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Outpatient Treatment for COVID-19</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Raglow, Zoe, Malani, Preeti N., Petty, Lindsey A.</div>
</div>
</div>
Wed, 27 Sep 2023 05:00:00 +0000Rowan Hutchins2085 at https://www.rpr.lib.ok.usEvaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity
https://www.rpr.lib.ok.us/resource/evaluation-waning-sars-cov-2-vaccine%E2%80%93induced-immunity
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-06-06T00:00:00-05:00">June 6, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">JAMA Netw Open</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">American Medical Association</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-05-03T00:00:00-05:00">May 3, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">6</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">5</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2804451?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=060423" target="_blank">Evaluation of Waning of SARS-CoV-2 Vaccine–Induced Immunity</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jamanetworkopen.2023.10650</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/covid-19-vaccine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 vaccine</a></div>
<div class="field-item even"><a href="/tags/vaccination-0" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">'Vaccination</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">37133863</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-vaccines" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19 Vaccines</a></div>
<div class="field-item even"><a href="/mesh/covid-19-prevention-control" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / prevention & control</a></div>
<div class="field-item odd"><a href="/mesh/covid-19-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19* / epidemiology</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>It looks like the COVID vaccines protect about as long as flu vaccines, 6 months for primary immunization, 9 months for the booster. Sounds like we will be getting one each year. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-5bbf5452aa1faafc7c0b84a47ff3ba68">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2804451?utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamanetworkopen&utm_content=mthlyforyou&utm_term=060423" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Importance Estimates of the rate of waning of vaccine effectiveness (VE) against COVID-19 are key to assess population levels of protection and future needs for booster doses to face the resurgence of epidemic waves.</p>
<p>Objective To quantify the progressive waning of VE associated with the Delta and Omicron variants of SARS-CoV-2 by number of received doses.</p>
<p>Data Sources PubMed and Web of Science were searched from the databases’ inception to October 19, 2022, as well as reference lists of eligible articles. Preprints were included.</p>
<p>Study Selection Selected studies for this systematic review and meta-analysis were original articles reporting estimates of VE over time against laboratory-confirmed SARS-CoV-2 infection and symptomatic disease.</p>
<p>Data Extraction and Synthesis Estimates of VE at different time points from vaccination were retrieved from original studies. A secondary data analysis was performed to project VE at any time from last dose administration, improving the comparability across different studies and between the 2 considered variants. Pooled estimates were obtained from random-effects meta-analysis.</p>
<p>Main Outcomes and Measures Outcomes were VE against laboratory-confirmed Omicron or Delta infection and symptomatic disease and half-life and waning rate associated with vaccine-induced protection.</p>
<p>Results A total of 799 original articles and 149 reviews published in peer-reviewed journals and 35 preprints were identified. Of these, 40 studies were included in the analysis. Pooled estimates of VE of a primary vaccination cycle against laboratory-confirmed Omicron infection and symptomatic disease were both lower than 20% at 6 months from last dose administration. Booster doses restored VE to levels comparable to those acquired soon after the administration of the primary cycle. However, 9 months after booster administration, VE against Omicron was lower than 30% against laboratory-confirmed infection and symptomatic disease. The half-life of VE against symptomatic infection was estimated to be 87 days (95% CI, 67-129 days) for Omicron compared with 316 days (95% CI, 240-470 days) for Delta. Similar waning rates of VE were found for different age segments of the population.</p>
<p>Conclusions and Relevance These findings suggest that the effectiveness of COVID-19 vaccines against laboratory-confirmed Omicron or Delta infection and symptomatic disease rapidly wanes over time after the primary vaccination cycle and booster dose. These results can inform the design of appropriate targets and timing for future vaccination programs.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Menegale, Francesco, Manica, Mattia, Zardini, Agnese, Guzzetta, Giorgio, Marziano, Valentina, d'Andrea, Valeria, Trentini, Filippo, Ajelli, Marco, Poletti, Piero, Merler, Stefano</div>
</div>
</div>
Tue, 06 Jun 2023 05:00:00 +0000Rowan Hutchins2053 at https://www.rpr.lib.ok.usDynamics of Naturally-Acquired Immunity Against SARS-CoV-2 in Children and Adolescents
https://www.rpr.lib.ok.us/resource/dynamics-naturally-acquired-immunity-against-sars-cov-2-children-and-adolescents
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-03-04T00:00:00-06:00">March 4, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">The Journal of Pediatrics</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Elsevier</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-03-02T00:00:00-06:00">March 2, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://www.jpeds.com/article/S0022-3476(23)00128-2/fulltext?dgcid=raven_jbs_aip_email" target="_blank">Dynamics of Naturally-Acquired Immunity Against SARS-CoV-2 in Children and Adolescents</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1016/j.jpeds.2023.02.016</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/tags/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
<div class="field-item even"><a href="/tags/waning-immunity" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">waning immunity</a></div>
<div class="field-item odd"><a href="/tags/naturally-aquired-immunity" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">naturally aquired immunity</a></div>
<div class="field-item even"><a href="/tags/infection-induced-immunity" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">infection-induced immunity</a></div>
<div class="field-item odd"><a href="/tags/adolescents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">adolescents</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/adolescent" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">adolescent</a></div>
<div class="field-item odd"><a href="/mesh/reinfection" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Reinfection</a></div>
<div class="field-item even"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item odd"><a href="/mesh/sars-cov-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">SARS-CoV-2</a></div>
<div class="field-item even"><a href="/mesh/retrospective-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">retrospective studies</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Children and adolescents appear to develop long-lasting immunity after natural infection with COVID-19. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
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<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-99322dc4e2b5cad8bc98bf853972e89d">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://www.jpeds.com/article/S0022-3476(23)00128-2/fulltext?dgcid=raven_jbs_aip_email" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
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<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Background<br />
To evaluate the duration of protection against reinfection conferred by a previous SARS-CoV-2 infection in children and adolescents.<br />
Methods<br />
We applied two complementary approaches: a matched test-negative, case-control design and a retrospective cohort design. 458,959 unvaccinated individuals aged 5-18 years were included. Analyses focused on July 1 to December 13, 2021, a period of Delta variant dominance in Israel. We evaluated three SARS-CoV-2-related outcomes: documented PCR confirmed infection or reinfection, symptomatic infection or reinfection, and SARS-CoV-2-related hospitalization or death.<br />
Findings<br />
Overall, children and adolescents who were previously infected acquired durable protection against reinfection with SARS-CoV-2 for at least 18 months. Importantly, no SARS-CoV-2-related deaths were recorded in either the SARS-CoV-2 naïve group or the previously infected group. Effectiveness of naturally-acquired immunity against a recurrent infection reached 89.2% (95% CI: 84.7%-92.4%) three to six months after first infection, mildly declining to 82.5% (95% CI, 79.1%-85.3%) 9-12 months after infection, with a slight non-significant waning trend up to 18 months after infection. Additionally, we found that ages 5-11 years exhibited no significant waning of naturally acquired protection throughout the outcome period, whereas waning protection in the 12-18 year-old age group was more prominent, but still mild.<br />
Interpretation<br />
Children and adolescents who were previously infected with SARS-CoV-2 remain protected to a high degree for 18 months. Further research is needed to examine naturally-acquired immunity against Omicron and newer emerging variants.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Patalon, T., Saciuk, Y., Perez, G., Peretz, A., Ben-Tov, A., Gazit, S.</div>
</div>
</div>
Sat, 04 Mar 2023 06:00:00 +0000Aubrey Delammermore1995 at https://www.rpr.lib.ok.usManagement of chronic respiratory diseases during viral pandemics: A concise review of guidance and recommendations
https://www.rpr.lib.ok.us/resource/management-chronic-respiratory-diseases-during-viral-pandemics-concise-review-guidance-and
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-01-07T00:00:00-06:00">January 7, 2023</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of Family Medicine and Primary Care</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Wolters Kluwer</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2022-11-01T00:00:00-05:00">November 1, 2022</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">11</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">11</div>
</div>
</div>
<div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix">
<div class="field-label">Pages: </div>
<div class="field-items">
<div class="field-item even">6633-6639</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://journals.lww.com/jfmpc/Fulltext/2022/11000/Management_of_chronic_respiratory_diseases_during.5.aspx/?cid=eTOC%20Issues.2021-jfmpc-01697686-202211000-00000&rid=V_0000000132003641&TargetID=&EjpToken=HL6S2BaHFY1sIMTMTC3dFZEpJ-2XOVQs2n0dVWQYhTt75ObB6q1lvzUvDqD6nBqjTC2-qFrb71UnyxfBeQ" target="_blank">Management of chronic respiratory diseases during viral pandemics: A concise review of guidance and recommendations</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even"> 10.4103/jfmpc.jfmpc_974_21</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/asthma" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">asthma</a></div>
<div class="field-item odd"><a href="/tags/interstitial-lung-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">interstitial lung disease</a></div>
<div class="field-item even"><a href="/tags/management" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">management</a></div>
<div class="field-item odd"><a href="/tags/recommendations" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">recommendations</a></div>
<div class="field-item even"><a href="/tags/copd" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">copd</a></div>
<div class="field-item odd"><a href="/tags/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/pandemics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pandemics</a></div>
<div class="field-item odd"><a href="/mesh/respiration-disorders" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Respiration Disorders</a></div>
<div class="field-item even"><a href="/mesh/pulmonary-disease-chronic-obstructive" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pulmonary disease, chronic obstructive</a></div>
<div class="field-item odd"><a href="/mesh/covid-19" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">COVID-19</a></div>
<div class="field-item even"><a href="/mesh/respiratory-insufficiency" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Respiratory Insufficiency</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Important evidence-based strategies for reducing morbidity and mortality from acute respiratory infections in patients with chronic lung diseases. James W. Mold MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
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<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://journals.lww.com/jfmpc/Fulltext/2022/11000/Management_of_chronic_respiratory_diseases_during.5.aspx/?cid=eTOC%20Issues.2021-jfmpc-01697686-202211000-00000&rid=V_0000000132003641&TargetID=&EjpToken=HL6S2BaHFY1sIMTMTC3dFZEpJ-2XOVQs2n0dVWQYhTt75ObB6q1lvzUvDqD6nBqjTC2-qFrb71UnyxfBeQ" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
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</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an acute respiratory disease that can lead to respiratory failure and death. Although anticipated that patients with chronic respiratory diseases would be at increased risk of SARS-CoV-2 infection and more severe presentations of COVID-19, it is striking that these diseases appear to be underrepresented in the comorbidities reported for patients with COVID-19. The first wave of COVID-19 has taught us important lessons concerning the enormous burden on the hospitals, shortage of beds, cross infections and transmissions, which we coped together. However, with the subsequent waves of COVID-19 or any other viral pandemic, to ensure that patients with respiratory illnesses receive adequate management for their diseases while minimizing their hospital visits for their own safety. Hence, we prepared an evidence-based summary to manage outpatients and inpatients suspected or diagnosed with COPD, asthma and ILD based on the experience of the first wave of COVID-19 and recommendations by expert societies and organizations.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Sharma, P., Mishra, M., Dua, R., Saini, L. K., Sindhwani, G.</div>
</div>
</div>
Sat, 07 Jan 2023 06:00:00 +0000Aubrey Delammermore1951 at https://www.rpr.lib.ok.us