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https://www.rpr.lib.ok.us/taxonomy/term/3113/all
enEstimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study
https://www.rpr.lib.ok.us/resource/estimates-all-cause-mortality-and-cause-specific-mortality-associated-proton-pump
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-09-18T00:00:00-05:00">September 18, 2019</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">BMJ</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">BMJ Publishing Group Limited</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-05-29T00:00:00-05:00">May 29, 2019</span></div>
</div>
</div>
<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
<div class="field-items">
<div class="field-item even">I1580</div>
</div>
</div>
<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
<div class="field-items">
<div class="field-item even">365</div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31147311" target="_blank">Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1136/bmj.l1580</div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/proton-pump-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">proton pump inhibitors</a></div>
<div class="field-item odd"><a href="/tags/mortality" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mortality</a></div>
<div class="field-item even"><a href="/tags/peptic-ulcer" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">peptic ulcer</a></div>
<div class="field-item odd"><a href="/tags/longitudinal-study" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">longitudinal study</a></div>
<div class="field-item even"><a href="/tags/veterans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">veterans</a></div>
</div>
</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
<div class="field-items">
<div class="field-item even">31147311</div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aged</a></div>
<div class="field-item odd"><a href="/mesh/cardiovascular-diseasesmortality" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular diseases/mortality</a></div>
<div class="field-item even"><a href="/mesh/cause-death" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cause of death</a></div>
<div class="field-item odd"><a href="/mesh/cohort-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cohort studies</a></div>
<div class="field-item even"><a href="/mesh/female" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">female</a></div>
<div class="field-item odd"><a href="/mesh/gastrointestinal-neoplasmsmortality" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">gastrointestinal neoplasms/mortality</a></div>
<div class="field-item even"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div>
<div class="field-item odd"><a href="/mesh/longitudinal-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Longitudinal Studies</a></div>
<div class="field-item even"><a href="/mesh/male" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">male</a></div>
<div class="field-item odd"><a href="/mesh/middle-aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Middle Aged</a></div>
<div class="field-item even"><a href="/mesh/mortality" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Mortality</a></div>
<div class="field-item odd"><a href="/mesh/peptic-ulcerprevention-control" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Peptic Ulcer/prevention & control</a></div>
<div class="field-item even"><a href="/mesh/proton-pump-inhibitorstherapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">proton pump inhibitors/therapeutic use</a></div>
<div class="field-item odd"><a href="/mesh/renal-insufficiency" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">renal insufficiency</a></div>
<div class="field-item even"><a href="/mesh/chronicmortality" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">chronic/mortality</a></div>
<div class="field-item odd"><a href="/mesh/risk-factors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">risk factors</a></div>
<div class="field-item even"><a href="/mesh/united-statesepidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">United States/epidemiology</a></div>
<div class="field-item odd"><a href="/mesh/veterans-healthstatistics-numerical-data" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">veterans health/statistics & numerical data</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Predictably PPIs are not as safe for long term use as we had hoped. It’s not wise to mess with Mother Nature. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-2c3fd54c654adddfee69ea615fe42497">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://www.ncbi.nlm.nih.gov/pubmed/31147311" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>OBJECTIVE:</p>
<p>To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs).</p>
<p>DESIGN:</p>
<p>Longitudinal observational cohort study.</p>
<p>SETTING:</p>
<p>US Department of Veterans Affairs.</p>
<p>PARTICIPANTS:</p>
<p>New users of PPIs (n=157 625) or H2 blockers (n=56 842).</p>
<p>MAIN OUTCOME MEASURES:</p>
<p>All cause mortality and cause specific mortality associated with taking PPIs (values reported as number of attributable deaths per 1000 patients taking PPIs).</p>
<p>RESULTS:</p>
<p>There were 45.20 excess deaths (95% confidence interval 28.20 to 61.40) per 1000 patients taking PPIs. Circulatory system diseases (number of attributable deaths per 1000 patients taking PPIs 17.47, 95% confidence interval 5.47 to 28.80), neoplasms (12.94, 1.24 to 24.28), infectious and parasitic diseases (4.20, 1.57 to 7.02), and genitourinary system diseases (6.25, 3.22 to 9.24) were associated with taking PPIs. There was a graded relation between cumulative duration of PPI exposure and the risk of all cause mortality and death due to circulatory system diseases, neoplasms, and genitourinary system diseases. Analyses of subcauses of death suggested that taking PPIs was associated with an excess mortality due to cardiovascular disease (15.48, 5.02 to 25.19) and chronic kidney disease (4.19, 1.56 to 6.58). Among patients without documented indication for acid suppression drugs (n=116 377), taking PPIs was associated with an excess mortality due to cardiovascular disease (22.91, 11.89 to 33.57), chronic kidney disease (4.74, 1.53 to 8.05), and upper gastrointestinal cancer (3.12, 0.91 to 5.44). Formal interaction analyses suggested that the risk of death due to these subcauses was not modified by a history of cardiovascular disease, chronic kidney disease, or upper gastrointestinal cancer. Taking PPIs was not associated with an excess burden of transportation related mortality and death due to peptic ulcer disease (as negative outcome controls).</p>
<p>CONCLUSIONS:</p>
<p>Taking PPIs is associated with a small excess of cause specific mortality including death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer. The burden was also observed in patients without an indication for PPI use. Heightened vigilance in the use of PPI may be warranted.</p>
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</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Xie, Y, Bowe, B, Yan, Y, Xian, H, Li, T, Al-Aly, Z</div>
</div>
</div>
Wed, 18 Sep 2019 17:02:59 +0000John Bayhi746 at https://www.rpr.lib.ok.us