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https://www.rpr.lib.ok.us/taxonomy/term/2563/all
enConsistency of Direct to Consumer Genetic Testing Results Among Identical Twins
https://www.rpr.lib.ok.us/resource/consistency-direct-consumer-genetic-testing-results-among-identical-twins
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-06-18T00:00:00-05:00">June 18, 2019</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">The American Journal of Medicine</div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-06-15T00:00:00-05:00">June 15, 2019</span></div>
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<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Consistency%20of%20Direct%20to%20Consumer%20Genetic%20Testing%20Results%20Among%20Identical%20Twins" target="_blank">Consistency of Direct to Consumer Genetic Testing Results Among Identical Twins</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Clinical Research Results</div>
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<div class="field-item even"> 10.1016/j.amjmed.2019.04.052</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
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<div class="field-item even"><a href="/tags/consistency" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">consistency</a></div>
<div class="field-item odd"><a href="/tags/genetic-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Genetic testing</a></div>
<div class="field-item even"><a href="/tags/identical-twins" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">identical twins</a></div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/dna" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">DNA</a></div>
<div class="field-item odd"><a href="/mesh/genetic-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">genetic testing</a></div>
<div class="field-item even"><a href="/mesh/direct-consumer-screening-and-testing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Direct-To-Consumer Screening and Testing</a></div>
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<div class="field-item even"><p>This study calls into question the accuracy of direct-to-consumer genetic testing. James W. Mold, MD, MPH</p>
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<div class="field-item even">Free full text</div>
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<a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Consistency%20of%20Direct%20to%20Consumer%20Genetic%20Testing%20Results%20Among%20Identical%20Twins" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field-item even" property="content:encoded"><p>Abstract</p>
<p>Purpose</p>
<p>To evaluate the consistency of 3 commonly used direct to consumer genetic testing kits.</p>
<p>Background</p>
<p>Genetic testing kits are widely marketed by several companies but the consistency of their results is unclear. Since identical twins share the same DNA, their genetic testing results should provide insight into test consistency.</p>
<p>Methods</p>
<p>42 identical twins (21 pairs) provided samples for three testing companies. Outcomes were concordance of ancestry results when i) twin pairs were tested by the same company and ii) the same participant was tested by different companies. Concordance of 8 self-reported traits with 23andMe genetic analyses were also examined.</p>
<p>Results</p>
<p>Concordance of ancestry results when twin pairs were tested by the same company was high, with mean percent agreement ranging from 94.5%–99.2%. Concordance of ancestry results when participants were tested by two different companies was lower, with mean percent agreement ranging from 52.7%–84.1%. Concordance of trait results was variable, ranging from 34.1% for deep sleep and detached earlobes to 90.2% for cleft chin.</p>
<p>Conclusion</p>
<p>The consistency of consumer genetic testing is high for ancestry results within companies but lower and more variable for ancestry results across companies and for specific traits. These results raise questions about the usefulness of such testing.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Huml, A.M., Sullivan C., Figueroa, M., Scott, K., Sehgal, A.R.</div>
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Wed, 19 Jun 2019 00:34:45 +0000Brian Desmarais613 at https://www.rpr.lib.ok.us