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https://www.rpr.lib.ok.us/taxonomy/term/2006/all
enWhat Are Polygenic Scores and Why Are They Important?
https://www.rpr.lib.ok.us/resource/what-are-polygenic-scores-and-why-are-they-important
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-04-09T00:00:00-05:00">April 9, 2019</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">JAMA</div>
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<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">American Medical Association</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-04-08T00:00:00-05:00">April 8, 2019</span></div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even">10.1001/jama.2019.3893</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/mendelian-disorders" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mendelian disorders</a></div>
<div class="field-item odd"><a href="/tags/monogenic-traits" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">monogenic traits</a></div>
<div class="field-item even"><a href="/tags/polygenic-scores" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">polygenic scores</a></div>
<div class="field-item odd"><a href="/tags/genetics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">genetics</a></div>
<div class="field-item even"><a href="/tags/genomics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">genomics</a></div>
<div class="field-item odd"><a href="/tags/precision-health" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">precision health</a></div>
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<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">30958510</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/eye-color" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">eye color</a></div>
<div class="field-item odd"><a href="/mesh/multifactorial-inheritance" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">multifactorial inheritance</a></div>
<div class="field-item even"><a href="/mesh/genomics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">genomics</a></div>
<div class="field-item odd"><a href="/mesh/dna" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">DNA</a></div>
<div class="field-item even"><a href="/mesh/risk-factors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">risk factors</a></div>
<div class="field-item odd"><a href="/mesh/cardiovascular-diseases" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular diseases</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>Polygenic prediction scores are the next thing to watch for in the genomics arena. It is probably worth reading about them now. This is a concise 1 ½-page summary. James W. Mold, MD, MPH</p>
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<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Commercial full text (fees may apply)</div>
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<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
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<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-fba90a95741f8adf28c6be9452588deb">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://jamanetwork.com/journals/jama/fullarticle/2730627" class="btn btn-primary" target="_blank">View</a> </div>
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</div></div>
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<div class="field field-name-body field-type-text-with-summary field-label-hidden">
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<div class="field-item even" property="content:encoded"><p><a href="https://sites.jamanetwork.com/genetics/index.html#mendelian-disorder">Mendelian disorders</a> and monogenic traits result from combinations of <a href="https://sites.jamanetwork.com/genetics/index.html#variant">variants</a> in 1 or a few genes that have a large effect on the propensity for developing a certain disease or characteristic. In contrast, <a href="https://sites.jamanetwork.com/genetics/index.html#complex-trait">complex traits</a>, such as eye color or cardiovascular disease, are determined by variations occurring in many genes that have smaller effect sizes and act over long periods of time, often in concert with environmental factors. The cumulative risk derived from aggregating contributions of the many DNA variants associated with a complex trait or disease is referred to as a polygenic risk score (also known as a genetic risk score). This JAMA Genomics and Precision Health article explains polygenic risk scores as determinants of an individual’s inherited risk for complex disease.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Sugrue, Leo P., Desikan, Rahul S.</div>
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Tue, 09 Apr 2019 05:00:00 +0000Tracy Ashby499 at https://www.rpr.lib.ok.us