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dementia https://www.rpr.lib.ok.us/taxonomy/term/1623/all en Nonpharmacologic management of the behavioural and psychological symptoms of dementia https://www.rpr.lib.ok.us/resource/nonpharmacologic-management-behavioural-and-psychological-symptoms-dementia <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-03-25T00:00:00-05:00">March 25, 2025</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Canadian Medical Association Journal</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-03-24T00:00:00-05:00">March 24, 2025</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">11</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">197</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">E298-E299</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/40127912/" target="_blank">Nonpharmacologic management of the behavioural and psychological symptoms of dementia</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1503/cmaj.241076</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/tags/behavior" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">behavior</a></div> <div class="field-item even"><a href="/tags/nonpharmacological-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">nonpharmacological treatment</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">40127912</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/psychotic-disorders" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Psychotic Disorders</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognition</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>A concise review of non-pharmacological ways to address behavioral issues in patients with dementia. James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-aad61abe68686c62e6c83c9253f57a71"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://pubmed.ncbi.nlm.nih.gov/40127912/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>No abstract available.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Hana Brath, Lesley Wiesenfeld, Nathan M Stall</div> </div> </div> Tue, 25 Mar 2025 15:52:05 +0000 Alex Haga 2595 at https://www.rpr.lib.ok.us The Women’s Health Initiative Randomized Trials and Clinical Practice https://www.rpr.lib.ok.us/resource/women%E2%80%99s-health-initiative-randomized-trials-and-clinical-practice <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-05-13T00:00:00-05:00">May 13, 2024</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">JAMA</div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">JAMA</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-05-01T00:00:00-05:00">May 1, 2024</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/38691368/" target="_blank">The Women’s Health Initiative Randomized Trials and Clinical Practice</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1001/jama.2024.6542</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/vitamin-d" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">vitamin D</a></div> <div class="field-item odd"><a href="/tags/calcium" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">calcium</a></div> <div class="field-item even"><a href="/tags/menopause" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">menopause</a></div> <div class="field-item odd"><a href="/tags/menopausal-women" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Menopausal women</a></div> <div class="field-item even"><a href="/tags/womens-health-0" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Women&#039;s Health</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">38691368</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/nutrients" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Nutrients</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/hysterectomy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hysterectomy</a></div> <div class="field-item odd"><a href="/mesh/chronic-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">chronic disease</a></div> <div class="field-item even"><a href="/mesh/contraindications" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Contraindications</a></div> <div class="field-item odd"><a href="/mesh/colorectal-neoplasms" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Colorectal Neoplasms</a></div> <div class="field-item even"><a href="/mesh/dietary-supplements" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dietary supplements</a></div> <div class="field-item odd"><a href="/mesh/vitamin-d" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">vitamin D</a></div> <div class="field-item even"><a href="/mesh/menopause" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">menopause</a></div> <div class="field-item odd"><a href="/mesh/follow-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">follow-up studies</a></div> <div class="field-item even"><a href="/mesh/dietary-patterns" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dietary Patterns</a></div> <div class="field-item odd"><a href="/mesh/diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diet</a></div> <div class="field-item even"><a href="/mesh/diet-fat-restricted" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diet, fat-restricted</a></div> <div class="field-item odd"><a href="/mesh/breast-neoplasms" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">breast neoplasms</a></div> <div class="field-item even"><a href="/mesh/cardiovascular-diseases" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular diseases</a></div> <div class="field-item odd"><a href="/mesh/medroxyprogesterone-acetate" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Medroxyprogesterone Acetate</a></div> <div class="field-item even"><a href="/mesh/calcium" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">calcium</a></div> <div class="field-item odd"><a href="/mesh/postmenopause" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">postmenopause</a></div> <div class="field-item even"><a href="/mesh/estrogens" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Estrogens</a></div> <div class="field-item odd"><a href="/mesh/conjugated-usp" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Conjugated (USP)</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>A summary review of the results of the Womens Health Initiative Study pertaining to HRT, Vit D/calcium supplementation, and low-fat diet in menopausal women. James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-20273b652dc800920392f996c6d388c6"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://pubmed.ncbi.nlm.nih.gov/38691368/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Importance: Approximately 55 million people in the US and approximately 1.1 billion people worldwide are postmenopausal women. To inform clinical practice about the health effects of menopausal hormone therapy, calcium plus vitamin D supplementation, and a low-fat dietary pattern, the Women's Health Initiative (WHI) enrolled 161 808 postmenopausal US women (N = 68 132 in the clinical trials) aged 50 to 79 years at baseline from 1993 to 1998, and followed them up for up to 20 years.</p> <p>Observations: The WHI clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for treating moderate to severe vasomotor and other menopausal symptoms. These benefits of hormone therapy in early menopause, combined with lower rates of adverse effects of hormone therapy in early compared with later menopause, support initiation of hormone therapy before age 60 years for women without contraindications to hormone therapy who have bothersome menopausal symptoms. The WHI results do not support routinely recommending calcium plus vitamin D supplementation for fracture prevention in all postmenopausal women. However, calcium and vitamin D are appropriate for women who do not meet national guidelines for recommended intakes of these nutrients through diet. A low-fat dietary pattern with increased fruit, vegetable, and grain consumption did not prevent the primary outcomes of breast or colorectal cancer but was associated with lower rates of the secondary outcome of breast cancer mortality during long-term follow-up.</p> <p>Conclusions and relevance: For postmenopausal women, the WHI randomized clinical trials do not support menopausal hormone therapy to prevent cardiovascular disease or other chronic diseases. Menopausal hormone therapy is appropriate to treat bothersome vasomotor symptoms among women in early menopause, without contraindications, who are interested in taking hormone therapy. The WHI evidence does not support routine supplementation with calcium plus vitamin D for menopausal women to prevent fractures or a low-fat diet with increased fruits, vegetables, and grains to prevent breast or colorectal cancer. A potential role of a low-fat dietary pattern in reducing breast cancer mortality, a secondary outcome, warrants further study.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Manson, J.E., Crandall, C.J., Rossouw, J.E.</div> </div> </div> Mon, 13 May 2024 21:25:57 +0000 Alex Haga 2307 at https://www.rpr.lib.ok.us Effects of dance therapy on cognitive and mental health in adults aged 55 years and older with mild cognitive impairment: a systematic review and meta-analysis https://www.rpr.lib.ok.us/resource/effects-dance-therapy-cognitive-and-mental-health-adults-aged-55-years-and-older-mild <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-11-13T00:00:00-06:00">November 13, 2023</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">BMC Geriatrics</div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">BioMed Central</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2023-10-26T00:00:00-05:00">October 26, 2023</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">23</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">695</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-04406-y" target="_blank">Effects of dance therapy on cognitive and mental health in adults aged 55 years and older with mild cognitive impairment: a systematic review and meta-analysis</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1186/s12877-023-04406-y</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/dance-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dance therapy</a></div> <div class="field-item odd"><a href="/tags/mild-cognitive-impairment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Mild cognitive impairment</a></div> <div class="field-item even"><a href="/tags/older-adults" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">older adults</a></div> <div class="field-item odd"><a href="/tags/cognitive" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognitive</a></div> <div class="field-item even"><a href="/tags/mental-health" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mental health</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">37880590</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aged</a></div> <div class="field-item odd"><a href="/mesh/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognition</a></div> <div class="field-item even"><a href="/mesh/cognitive-dysfunction-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognitive Dysfunction* / therapy</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/dance-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dance therapy</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>Dance therapy improves cognitive function in people with mild cognitive impairment. Makes sense (Music plus physical activity). James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-08a29374b6f9f6cd4a8dc5ab8566a2a0"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-023-04406-y" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Background: Individuals with mild cognitive impairment are at high risk of developing dementia. Dance therapy has promising applications in delaying cognitive decline. However, the effectiveness of dance therapy for older adults with mild cognitive impairment is unclear. The objective of this review was to evaluate the effectiveness of dance therapy on global cognitive function, specific cognitive subdomains, quality of life, and mental health in older adults with mild cognitive impairment to enrich health management strategies for dementia.</p> <p>Methods: Electronic databases and grey literature were searched from inception up to September 23, 2023. The language was limited to English and Chinese. Relevant studies were screened and assessed for risk of bias. A meta-analysis and subgroup analyses stratified by measurement instrument, dance type, intervention duration, and frequency were conducted using the STATA 16.0 software. This review was conducted in accordance with the PRISMA guidelines.</p> <p>Results: Ten studies involving 984 participants aged 55 years and over who met the eligibility criteria were included. Dance therapy significantly improved global cognitive function, memory, executive function, attention, language, and mental health (i.e., depression and neuropsychiatric symptoms). However, the effects of dance therapy on processing speed, visuospatial ability, and quality of life in older adults with mild cognitive impairment remain inconclusive. Moreover, dance interventions of longer duration (&gt; 3 months) improved global cognition more than shorter interventions.</p> <p>Conclusion: This review reported that dance therapy was effective in improving global cognitive function, memory, executive function, attention, language, and mental health (i.e., depression and neuropsychiatric symptoms). Hence, it may be an effective non-pharmacological complementary treatment for older adults with mild cognitive impairment.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Chen-shan Huang, Yuan-jiao Yan, Yu-ting Luo, Rong Lin, Hong Li</div> </div> </div> Mon, 13 Nov 2023 16:54:42 +0000 Erin Blanchette 2151 at https://www.rpr.lib.ok.us Effectiveness of a Mouth Care Program Provided by Nursing Home Staff vs Standard Care on Reducing Pneumonia Incidence: A Cluster Randomized Trial https://www.rpr.lib.ok.us/resource/effectiveness-mouth-care-program-provided-nursing-home-staff-vs-standard-care-reducing <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-06-22T00:00:00-05:00">June 22, 2020</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">JAMA Network Open</div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">American Medical Association</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-06-01T00:00:00-05:00">June 1, 2020</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">6</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">3</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/32558913/" target="_blank">Effectiveness of a Mouth Care Program Provided by Nursing Home Staff vs Standard Care on Reducing Pneumonia Incidence: A Cluster Randomized Trial</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">https://doi.org/10.1001/jamanetworkopen.2020.4321</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/aspiration" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aspiration</a></div> <div class="field-item odd"><a href="/tags/dental-hygienists" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dental hygienists</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/long-term-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">long-term care</a></div> <div class="field-item odd"><a href="/mesh/female" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">female</a></div> <div class="field-item even"><a href="/mesh/incidence" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">incidence</a></div> <div class="field-item odd"><a href="/mesh/caregivers" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">caregivers</a></div> <div class="field-item even"><a href="/mesh/control-groups" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Control Groups</a></div> <div class="field-item odd"><a href="/mesh/oral-health" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">oral health</a></div> <div class="field-item even"><a href="/mesh/oral-hygiene" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Oral Hygiene</a></div> <div class="field-item odd"><a href="/mesh/p-30-composite-resin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">P-30 composite resin</a></div> <div class="field-item even"><a href="/mesh/north-carolina" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">North Carolina</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/hospitalization" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hospitalization</a></div> <div class="field-item odd"><a href="/mesh/pneumonia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pneumonia</a></div> <div class="field-item even"><a href="/mesh/nursing-home" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">nursing home</a></div> <div class="field-item odd"><a href="/mesh/medical-records" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Medical Records</a></div> <div class="field-item even"><a href="/mesh/mouth" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mouth</a></div> <div class="field-item odd"><a href="/mesh/attitude" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">attitude</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>The organisms responsible for pneumonia live in the mouth. Technically, nearly all pneumonias are due to aspiration.  At least one RCT in Japan showed that excellent oral hygiene (by dental hygienists) in NHs can reduce the incidence of pneumonia.  This study showed that enhanced oral hygiene performed by nurses reduced pneumonia episodes for the first year, and then the effect waned.  James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-d08bd8842bae15c39b693f994d9f48b8"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://pubmed.ncbi.nlm.nih.gov/32558913/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Abstract</p> <p><strong>Importance: </strong>Pneumonia affects more than 250 000 nursing home (NH) residents annually. A strategy to reduce pneumonia is to provide daily mouth care, especially to residents with dementia.</p> <p><strong>Objective: </strong>To evaluate the effectiveness of Mouth Care Without a Battle, a program that increases staff knowledge and attitudes regarding oral hygiene, changes mouth care, and improves oral hygiene, in reducing the incidence of pneumonia among NH residents.</p> <p><strong>Design, setting, and participants: </strong>This pragmatic cluster randomized trial observing 2152 NH residents for up to 2 years was conducted from September 2014 to May 2017. Data collectors were masked to study group. The study included 14 NHs from regions of North Carolina that evidenced proportionately high rehospitalization rates for pneumonia and long-term care residents. Nursing homes were pair matched and randomly assigned to intervention or control groups.</p> <p><strong>Intervention: </strong>Mouth Care Without a Battle is a standardized program that teaches that mouth care is health care, provides instruction on individualized techniques and products for mouth care, and trains caregivers to provide care to residents who are resistant and in special situations. The control condition was standard mouth care.</p> <p><strong>Main outcomes and measures: </strong>Pneumonia incidence (primary) and hospitalization and mortality (secondary), obtained from medical records.</p> <p><strong>Results: </strong>Overall, the study enrolled 2152 residents (mean [SD] age, 79.4 [12.4] years; 1281 [66.2%] women; 1180 [62.2%] white residents). Participants included 1219 residents (56.6%) in 7 intervention NHs and 933 residents (43.4%) in 7 control NHs. During the 2-year study period, the incidence rate of pneumonia per 1000 resident-days was 0.67 and 0.72 in the intervention and control NHs, respectively. Neither the primary (unadjusted) nor secondary (covariate-adjusted) analyses found a significant reduction in pneumonia due to Mouth Care Without a Battle during 2 years (unadjusted incidence rate ratio, 0.90; upper bound of 1-sided 95% CI, 1.24; P = .27; adjusted incidence rate ratio, 0.92; upper bound of 1-sided 95% CI, 1.27; P = .30). In the second year, the rate of pneumonia was nonsignificantly higher in intervention NHs. Adjusted post hoc analyses limited to the first year found a significant reduction in pneumonia incidence in intervention NHs (IRR, 0.69; upper bound of 1-sided 95% CI, 0.94; P = .03).</p> <p><strong>Conclusions and relevance: </strong>This matched-pairs cluster randomized trial of a mouth care program compared with standard care was not effective in reducing pneumonia incidence at 2 years, although reduction was found during the first year. The lack of significant results in the second year may be associated with sustainability. Improving mouth care in US NHs may require the presence and support of dedicated oral care aides.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Zimmerman, S., Sloane, P.D., Ward, K., Wretman, C.J., Stearns, S.C., Poole, P., Preisser, J.S.</div> </div> </div> Mon, 22 Jun 2020 15:39:47 +0000 Brian Desmarais 1208 at https://www.rpr.lib.ok.us Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia https://www.rpr.lib.ok.us/resource/diagnosis-and-treatment-clinical-alzheimer%E2%80%99s-type-dementia <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-05-01T00:00:00-05:00">May 1, 2020</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Comparative Effectiveness Review</div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">Agency for Healthcare Research and Quality</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-04-20T00:00:00-05:00">April 20, 2020</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://effectivehealthcare.ahrq.gov/products/alzheimers-type-dementia/research" target="_blank">Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">https://doi.org/10.23970/AHRQEPCCER223</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/cognitive-screening-tests" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cognitive screening tests</a></div> <div class="field-item odd"><a href="/tags/alzheimers-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">alzheimer&#039;s disease</a></div> <div class="field-item even"><a href="/tags/treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">treatment</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/cholinesterase-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cholinesterase Inhibitors</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognition</a></div> <div class="field-item odd"><a href="/mesh/treatment-outcome" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">treatment outcome</a></div> <div class="field-item even"><a href="/mesh/biomarkers" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Biomarkers</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>A review of the evidence regarding cognitive screening tests used to “diagnose” (identify patients with cognitive impairment that could be Alzheimer’s Disease) and the (lack of) effectiveness of currently available medications use to treat it.  James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-1af298b4949d327e429a3bbd13571169"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://effectivehealthcare.ahrq.gov/products/alzheimers-type-dementia/research" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p><strong>Objective.</strong> To summarize evidence on: (1) the accuracy of brief cognitive tests for identifying clinical Alzheimer’s-type dementia (CATD) in individuals with suspected cognitive impairment; (2) the accuracy of biomarkers for identifying Alzheimer’s disease (AD) in individuals with dementia; and (3) the benefits and harms of prescription drugs and supplements for cognition, function, and behavioral and psychological symptoms of dementia (BPSD) in patients with CATD.</p> <p><strong>Data sources.</strong> Electronic bibliographic databases to March 2019, ClinicalTrials.gov, systematic review bibliographies.</p> <p><strong>Review methods.</strong> Cognitive test accuracy studies must have used explicit CATD diagnostic criteria and a non-CATD control group. Biomarker accuracy studies must have used neuropathologic criteria to define AD cases and non-AD controls. All treatment trials must have enrolled participants with CATD; those evaluating BPSD enrolled individuals with CATD and BPSD. Minimum trial duration was 2 weeks for agitation, aggression, psychosis, and disinhibited sexual behavior, and 24 weeks for other outcomes. Two reviewers rated risk of bias (ROB) and strength of evidence. One reviewer extracted data; a second checked accuracy. We analyzed English-language studies with low or medium ROB.</p> <p><strong>Results.</strong> We analyzed 56 unique studies on the accuracy of brief cognitive tests for CATD, 24 on accuracy of biomarkers for AD (15 brain imaging, nine cerebrospinal fluid [CSF] testing), and 67 trials of CATD treatment (54 reporting cognition or function, 13 reporting BPSD). Multiple brief cognitive tests were highly sensitive and specific (&gt;0.8) for distinguishing CATD from normal cognition, but less so for distinguishing mild CATD from normal cognition or CATD from mild cognitive impairment (MCI). Based on few studies, compared with clinical evaluation alone, amyloid positron emission tomography (PET), fluorodeoxyglucose (FDG)-PET, and combinations of CSF tests added to clinical evaluation may improve accuracy for distinguishing AD from non-AD dementia. Regardless of CATD severity, cholinesterase-inhibitors produced small improvements in cognition and function compared with placebo but may increase serious adverse events and withdrawals due to adverse events. For moderate to severe CATD, memantine plus a cholinesterase inhibitor slightly improved global change and inconsistently improved cognition, but not function, compared with a cholinesterase inhibitor alone. Evidence was mostly insufficient about the effects of prescription drugs and supplements on agitation, aggression, psychosis, or disinhibited sexual behavior.</p> <p><strong>Conclusion.</strong> Brief cognitive tests accurately distinguished CATD from normal cognition, but were less accurate distinguishing smaller clinical differences. Whether biomarkers improve diagnostic accuracy when added to clinical evaluation needs further verification, but potential benefits of testing are limited by lack of effective treatments for AD and non-AD dementias. Cholinesterase-inhibitors slightly outperformed placebo for cognition and function, but evidence of whether any drug treatments improved BPSD was largely insufficient.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Hemmy, L.S, Fink, H.A., Linskens, E.J., Silverman, P.G., MacDonald, R., McCarten, J.R., Talley, K.M.C., Desai, P.J., Forte, M.L., Miller, M.A., Brasure, M., Nelson, V.A., Taylor, B.C., Ng, W., Ouellette, J.M., Greer, N.L., Sheets, K.M., Wilt, T.J., Butler, M.</div> </div> </div> Fri, 01 May 2020 15:44:37 +0000 Brian Desmarais 1128 at https://www.rpr.lib.ok.us The Potential Emergence of Disease-Modifying Treatments for Alzheimer Disease: The Role of Primary Care in Managing the Patient Journey https://www.rpr.lib.ok.us/resource/potential-emergence-disease-modifying-treatments-alzheimer-disease-role-primary-care <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2020-01-09T00:00:00-06:00">January 9, 2020</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Journal of the American Board of Family Medicine</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-11-01T00:00:00-05:00">November 1, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">6</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">32</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">931-940</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=The%20Potential%20Emergence%20of%20Disease-Modifying%20Treatments%20for%20Alzheimer%20Disease%3A%20The%20Role%20of%20Primary%20Care%20in%20Managing%20the%20Patient%20Journey" target="_blank">The Potential Emergence of Disease-Modifying Treatments for Alzheimer Disease: The Role of Primary Care in Managing the Patient Journey</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.3122/jabfm.2019.06.180328</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/alzheimer-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Alzheimer Disease</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/alzheimer-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">alzheimer disease</a></div> <div class="field-item odd"><a href="/mesh/diagnostic-tests" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Diagnostic Tests</a></div> <div class="field-item even"><a href="/mesh/routine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">routine</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/disease-progression" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Disease Progression</a></div> <div class="field-item odd"><a href="/mesh/prevalence" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">prevalence</a></div> <div class="field-item even"><a href="/mesh/publications" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Publications</a></div> <div class="field-item odd"><a href="/mesh/primary-health-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">primary health care</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>This opinion piece provides an update on the status of diagnostic tests and possible new treatments for Alzheimer’s Disease. I am posting it so that you can answer patients’ and families’ questions.  I do believe that adding a brief cognitive test to the AWV makes sense, since, for clinical purposes, you need to know whether patients have short term memory deficits, and the only way to reliably determine that is with testing.  In my practice and in the one I now attend as a patient, we/they use(d) the Short Blessed Test (SBT), which only takes the nurse about 2-3 minutes to administer.  James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-8b41e9930f9396c32bae136f69b9ab9b"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=The%20Potential%20Emergence%20of%20Disease-Modifying%20Treatments%20for%20Alzheimer%20Disease%3A%20The%20Role%20of%20Primary%20Care%20in%20Managing%20the%20Patient%20Journey" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Despite recent setbacks, disease-modifying treatments (DMTs) for Alzheimer disease (AD) might become available within a few years. These DMTs are likely to be used in the early stages of AD to avoid the progression to manifest dementia, which implies that a large reservoir of prevalent cases would need to be evaluated when DMTs first become available. Primary care providers (PCPs) would play a vital role in managing the patient flow to specialty care. We review the literature on diagnostic tests that could be used by PCPs and estimate the impact of different testing approaches on demand for specialty care.While many tests have been evaluated, only the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) perform acceptably for detection of early-stage cognitive decline with sensitivities and specificities of 55% to 82% and 72% to 84%, respectively, for the MMSE; and 77% to 96% and 73% to 95%, respectively, for the MoCA. However, neither test is sufficiently specific for the AD pathology and would result in 4 to 5 false positives for each true positive. Blood-based tests for AD biomarkers may soon become available for clinical use. A plasma amyloid-β (Aβ) test has been shown to have a sensitivity of up to 97% and specificity of up to 81%. Adding this test to the MMSE or MoCA could reduce false positives by approximately 80%.These findings suggest a combination of brief cognitive tests and blood-based biomarker tests will allow PCPs to identify patients with potential early stage AD efficiently and triage them for further evaluation.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Lam, J., Hlávka, J., Mattke, S.</div> </div> </div> Thu, 09 Jan 2020 15:51:26 +0000 Brian Desmarais 905 at https://www.rpr.lib.ok.us Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial https://www.rpr.lib.ok.us/resource/sex-difference-effects-low-dose-aspirin-prevention-dementia-patients-type-2-diabetes-long <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-12-09T00:00:00-06:00">December 9, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Diabetes Care</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-12-04T00:00:00-06:00">December 4, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sex%20Difference%20in%20Effects%20of%20Low-Dose%20Aspirin%20on%20Prevention%20of%20Dementia%20in%20Patients%20With%20Type%202%20Diabetes%3A%20A%20Long-term%20Follow-up%20Study%20of%20a%20Randomized%20Clinical%20Trial" target="_blank">Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial.</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.2337/dc19-1188</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/aspirin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aspirin</a></div> <div class="field-item odd"><a href="/tags/low-dose-aspirin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">low-dose aspirin</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/aspirin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aspirin</a></div> <div class="field-item odd"><a href="/mesh/diabetes-mellitus-type-2" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diabetes mellitus, type 2</a></div> <div class="field-item even"><a href="/mesh/follow-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">follow-up studies</a></div> <div class="field-item odd"><a href="/mesh/incidence" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">incidence</a></div> <div class="field-item even"><a href="/mesh/primary-prevention" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">primary prevention</a></div> <div class="field-item odd"><a href="/mesh/atherosclerosis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">atherosclerosis</a></div> <div class="field-item even"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>And yet more information about the potential value (reduced risk of dementia) of low-dose aspirin, this time in women with Type 2 diabetes.</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Commercial full text (fees may apply)</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-d775d8d581a8d24ef0270370c63e61c5"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Sex%20Difference%20in%20Effects%20of%20Low-Dose%20Aspirin%20on%20Prevention%20of%20Dementia%20in%20Patients%20With%20Type%202%20Diabetes%3A%20A%20Long-term%20Follow-up%20Study%20of%20a%20Randomized%20Clinical%20Trial" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>OBJECTIVE:</p> <p>To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women.</p> <p>RESEARCH DESIGN AND METHODS:</p> <p>This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care-controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia.</p> <p>RESULTS:</p> <p>Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58-1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36-0.95), but not in men (HR 1.27, 95% CI 0.75-2.13) (<em>P</em> interaction = 0.03).</p> <p>CONCLUSIONS:</p> <p>Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Matsumoto, C., Ogawa, H., Saito, Y., Okada S., Soejima, H., Sakuma, M., Masuda, I., Nakayama, M., Doi, N., Jinnouchi, H., Waki, M., Morimoto, T., JPAD Trial Investigators</div> </div> </div> Mon, 09 Dec 2019 19:29:10 +0000 Brian Desmarais 869 at https://www.rpr.lib.ok.us Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study https://www.rpr.lib.ok.us/resource/anticholinergic-drug-exposure-and-risk-dementia-nested-case-control-study <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-06-27T00:00:00-05:00">June 27, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Journal of the American Medical Association Internal Medicine</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-06-24T00:00:00-05:00">June 24, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/31233095" target="_blank">Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1001/jamainternmed.2019.0677.</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/tags/middle-aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">middle aged</a></div> <div class="field-item even"><a href="/tags/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cognition</a></div> <div class="field-item odd"><a href="/tags/antipsychotic-drugs" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antipsychotic drugs</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/muscarinic-antagonists" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Muscarinic Antagonists</a></div> <div class="field-item odd"><a href="/mesh/antipsychotic-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">antipsychotic agents</a></div> <div class="field-item even"><a href="/mesh/middle-aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Middle Aged</a></div> <div class="field-item odd"><a href="/mesh/anticonvulsants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Anticonvulsants</a></div> <div class="field-item even"><a href="/mesh/confounding-factors-epidemiology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Confounding Factors (Epidemiology)</a></div> <div class="field-item odd"><a href="/mesh/urinary-bladder" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Urinary Bladder</a></div> <div class="field-item even"><a href="/mesh/cholinergic-antagonists" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cholinergic antagonists</a></div> <div class="field-item odd"><a href="/mesh/antidepressive-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">antidepressive agents</a></div> <div class="field-item even"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/mesh/antiparkinson-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antiparkinson Agents</a></div> <div class="field-item even"><a href="/mesh/primary-health-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">primary health care</a></div> <div class="field-item odd"><a href="/mesh/general-practice" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">General Practice</a></div> <div class="field-item even"><a href="/mesh/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognition</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p> I am only posting this article because your patients may ask about it.  The research design isn’t very strong, and the association strengths aren’t terribly impressive.  The dementia diagnoses weren’t confirmed, and I can’t tell whether patients were still taking the meds, which we know can cause acute cognitive impairment..   James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Commercial full text (fees may apply)</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-3e346c127430c9a51b445a0c287c0c11"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/31233095" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>IMPORTANCE:</p> <p>Anticholinergic medicines have short-term cognitive adverse effects, but it is uncertain whether long-term use of these drugs is associated with an increased risk of dementia.</p> <p>OBJECTIVE:</p> <p>To assess associations between anticholinergic drug treatments and risk of dementia in persons 55 years or older.</p> <p>DESIGN, SETTING, AND PARTICIPANTS:</p> <p>This nested case-control study took place in general practices in England that contributed to the QResearch primary care database. The study evaluated whether exposure to anticholinergic drugs was associated with dementia risk in 58 769 patients with a diagnosis of dementia and 225 574 controls 55 years or older matched by age, sex, general practice, and calendar time. Information on prescriptions for 56 drugs with strong anticholinergic properties was used to calculate measures of cumulative anticholinergic drug exposure. Data were analyzed from May 2016 to June 2018.</p> <p>EXPOSURES:</p> <p>The primary exposure was the total standardized daily doses (TSDDs) of anticholinergic drugs prescribed in the 1 to 11 years prior to the date of diagnosis of dementia or equivalent date in matched controls (index date).</p> <p>MAIN OUTCOMES AND MEASURES:</p> <p>Odds ratios (ORs) for dementia associated with cumulative exposure to anticholinergic drugs, adjusted for confounding variables.</p> <p>RESULTS:</p> <p>Of the entire study population (284 343 case patients and matched controls), 179 365 (63.1%) were women, and the mean (SD) age of the entire population was 82.2 (6.8) years. The adjusted OR for dementia increased from 1.06 (95% CI, 1.03-1.09) in the lowest overall anticholinergic exposure category (total exposure of 1-90 TSDDs) to 1.49 (95% CI, 1.44-1.54) in the highest category (&gt;1095 TSDDs), compared with no anticholinergic drug prescriptions in the 1 to 11 years before the index date. There were significant increases in dementiarisk for the anticholinergic antidepressants (adjusted OR [AOR], 1.29; 95% CI, 1.24-1.34), antiparkinson drugs (AOR, 1.52; 95% CI, 1.16-2.00), antipsychotics (AOR, 1.70; 95% CI, 1.53-1.90), bladder antimuscarinic drugs (AOR, 1.65; 95% CI, 1.56-1.75), and antiepileptic drugs (AOR, 1.39; 95% CI, 1.22-1.57) all for more than 1095 TSDDs. Results were similar when exposures were restricted to exposure windows of 3 to 13 years (AOR, 1.46; 95% CI, 1.41-1.52) and 5 to 20 years (AOR, 1.44; 95% CI, 1.32-1.57) before the index date for more than 1095 TSDDs. Associations were stronger in cases diagnosed before the age of 80 years. The population-attributable fraction associated with total anticholinergic drug exposure during the 1 to 11 years before diagnosis was 10.3%.</p> <p>CONCLUSIONS AND RELEVANCE:</p> <p>Exposure to several types of strong anticholinergic drugs is associated with an increased risk ofdementia. These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Coupland, C.A.C., Hill, T., Dening, T., Morriss, R., Moore M., Hippisley-Cox J.</div> </div> </div> Thu, 27 Jun 2019 13:04:17 +0000 Brian Desmarais 633 at https://www.rpr.lib.ok.us Some benefits from donepezil in Alzheimer’s disease https://www.rpr.lib.ok.us/resource/some-benefits-donepezil-alzheimer%E2%80%99s-disease <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-06-20T00:00:00-05:00">June 20, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">British Journal of General Practice</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2013-03-01T00:00:00-06:00">March 1, 2013</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">63</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">608</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">150</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582964/" target="_blank">Some benefits from donepezil in Alzheimer’s disease</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Meta-analyses, Reviews, and Guidelines</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.3399/bjgp13X664333</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/donepezil" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">donepezil</a></div> <div class="field-item odd"><a href="/tags/alzheimers-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">alzheimer&#039;s disease</a></div> <div class="field-item even"><a href="/tags/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/tags/brain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">brain</a></div> <div class="field-item even"><a href="/tags/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cognition</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/donepezil" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">donepezil</a></div> <div class="field-item odd"><a href="/mesh/cholinesterase-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cholinesterase Inhibitors</a></div> <div class="field-item even"><a href="/mesh/acetylcholine" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Acetylcholine</a></div> <div class="field-item odd"><a href="/mesh/indans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Indans</a></div> <div class="field-item even"><a href="/mesh/piperidines" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Piperidines</a></div> <div class="field-item odd"><a href="/mesh/alzheimer-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">alzheimer disease</a></div> <div class="field-item even"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/mesh/cognition" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognition</a></div> <div class="field-item even"><a href="/mesh/synaptic-transmission" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Synaptic Transmission</a></div> <div class="field-item odd"><a href="/mesh/brain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">brain</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>RPR Commentary: This is a summary of the data available to date on the effectiveness of donepezil for treatment of patients with Alzheimer’s Disease.  I told patients and their families that if a small improvement in functional abilities would make a huge difference in quality of life (e.g. could remain at home 6 months longer), it is probably worth trying donepezil.  Otherwise the expense and side effects are not worth the very small benefit.  5 to 10mg seems to be enough.   James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-8237d08b4302efca88d488dd42e9bbb2"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582964/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>CLINICAL QUESTION</p> <p>How effective is exercise-based cardiac rehabilitation on mortality, morbidity, and health-related quality of life (QOL) in patients with coronary heart disease (CHD)?</p> <p>BOTTOM LINE</p> <p>Compared to usual care, in medium to longer-term follow-up (≥12 months) exercise-based cardiac rehabilitation was found to be effective in reducing overall and cardiovascular mortality in patients with CHD, and appeared to reduce the risk of hospital admissions in the shorter term (&lt;12 months follow-up). There was no reduction seen in the risk of total myocardial infarction, coronary artery bypass graft, or percutaneous transluminal coronary angioplasty.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">McAvoy, B.R.</div> </div> </div> Thu, 20 Jun 2019 12:57:52 +0000 Brian Desmarais 623 at https://www.rpr.lib.ok.us Legal Advocacy To Improve Care For Older Adults With Complex Needs https://www.rpr.lib.ok.us/resource/legal-advocacy-improve-care-older-adults-complex-needs <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-05-20T00:00:00-05:00">May 20, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Health Affairs</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-05-17T00:00:00-05:00">May 17, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.healthaffairs.org/do/10.1377/hblog20190514.199890/full/?utm_source=Newsletter&amp;utm_medium=email&amp;utm_content=Legal%20Advocacy%20For%20Older%20Adults%20With%20Complex%20Needs%3B%20Zero-Premium%20Health%20Insurance%20Plans%20In%20Federal%20Marketplaces&amp;utm_campaign=HAT%205-17-19&amp;" target="_blank">Legal Advocacy To Improve Care For Older Adults With Complex Needs</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Public Health Announcements</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Web Page</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/elderly-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Elderly care</a></div> <div class="field-item odd"><a href="/tags/elder-abuse" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">elder abuse</a></div> <div class="field-item even"><a href="/tags/social-workers" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">social workers</a></div> <div class="field-item odd"><a href="/tags/home-care" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">home care</a></div> <div class="field-item even"><a href="/tags/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/tags/medicare" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">medicare</a></div> <div class="field-item even"><a href="/tags/elderly" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">elderly</a></div> <div class="field-item odd"><a href="/tags/aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aged</a></div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/social-workers" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Social Workers</a></div> <div class="field-item odd"><a href="/mesh/elder-abuse" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Elder Abuse</a></div> <div class="field-item even"><a href="/mesh/social-welfare" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Social Welfare</a></div> <div class="field-item odd"><a href="/mesh/home-care-services" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Home Care Services</a></div> <div class="field-item even"><a href="/mesh/legal-services" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">legal services</a></div> <div class="field-item odd"><a href="/mesh/united-states" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">United States</a></div> <div class="field-item even"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item odd"><a href="/mesh/literacy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Literacy</a></div> <div class="field-item even"><a href="/mesh/housing" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Housing</a></div> <div class="field-item odd"><a href="/mesh/medicare" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">medicare</a></div> <div class="field-item even"><a href="/mesh/transportation" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Transportation</a></div> <div class="field-item odd"><a href="/mesh/aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aged</a></div> <div class="field-item even"><a href="/mesh/social-isolation" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Social Isolation</a></div> <div class="field-item odd"><a href="/mesh/case-managers" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Case Managers</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>A review of the important underappreciated role of legal advocates in supporting health care-related needs of older adults.  James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Free full text</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-c794cf66c9bfa0eec60d77e0a2586d78"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.healthaffairs.org/do/10.1377/hblog20190514.199890/full/?utm_source=Newsletter&amp;utm_medium=email&amp;utm_content=Legal%20Advocacy%20For%20Older%20Adults%20With%20Complex%20Needs%3B%20Zero-Premium%20Health%20Insurance%20Plans%20In%20Federal%20Marketplaces&amp;utm_campaign=HAT%205-17-19&amp;=" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Legal advocacy is a <a href="https://www.ncbi.nlm.nih.gov/pubmed/29505366" target="_blank">recognized strategy</a> to address social factors that influence the health of populations with complex care needs. Such advocacy can <a href="https://www.ncbi.nlm.nih.gov/pubmed/23020301" target="_blank">improve housing stability</a>, <a href="https://www.healthaffairs.org/doi/10.1377/hlthaff.2017.0759" target="_blank">increase access to public benefits</a> that support a host of social needs, assure that medical and financial proxy decision makers are in place, and <a href="https://www.ncbi.nlm.nih.gov/pubmed/23698668" target="_blank">reduce psychosocial distress</a>. </p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Hooper, Sarah, Parekh, Ami, Fabiny, Anne, Teitelbaum, Joel</div> </div> </div> Mon, 20 May 2019 05:00:00 +0000 Brian Desmarais 564 at https://www.rpr.lib.ok.us What Are the Components to the MIND Diet? https://www.rpr.lib.ok.us/resource/what-are-components-mind-diet <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2019-02-24T00:00:00-06:00">February 24, 2019</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Journal of the Academy of Nutrition and Dietetics</div> </div> </div> <div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix"> <div class="field-label">Publisher:&nbsp;</div> <div class="field-items"> <div class="field-item even">Elsevier</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2015-09-27T00:00:00-05:00">September 27, 2015</span></div> </div> </div> <div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix"> <div class="field-label">Issue:&nbsp;</div> <div class="field-items"> <div class="field-item even">10</div> </div> </div> <div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix"> <div class="field-label">Volume:&nbsp;</div> <div class="field-items"> <div class="field-item even">115</div> </div> </div> <div class="field field-name-field-artifact-pages field-type-text field-label-inline clearfix"> <div class="field-label">Pages:&nbsp;</div> <div class="field-items"> <div class="field-item even">1744</div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26407649" target="_blank">What Are the Components to the MIND Diet?</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Decision Aids, Patient Education Materials</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1016/j.jand.2015.08.002</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diet</a></div> <div class="field-item odd"><a href="/tags/mind-diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">MIND diet</a></div> <div class="field-item even"><a href="/tags/mediterranean-diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">mediterranean diet</a></div> <div class="field-item odd"><a href="/tags/dash-diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">DASH diet</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">26407649</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/alzheimer-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">alzheimer disease</a></div> <div class="field-item odd"><a href="/mesh/dementia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dementia</a></div> <div class="field-item even"><a href="/mesh/diet" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">diet</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>The MIND diet is a combination of the Mediterranean and DASH diets.  This short article provides lists of included and excluded foods.</p> </div> </div> </div> <div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden"> <div class="field-items"> <div class="field-item even">Commercial full text (fees may apply)</div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-721bce206a2cd1c7b0ca6f22ed76e16e"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26407649" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>The MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) has been attributed to improved cognitive thinking and lowering the risk and slowing the progression of Alzheimer disease—the leading cause of dementia.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Marcason, Wendy</div> </div> </div> Sun, 24 Feb 2019 19:51:26 +0000 Jeffrey Wilson 407 at https://www.rpr.lib.ok.us