Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Jeffrey Wilson — Sun, 24 Feb 2019 19:23:57 +0000

Date Added:

February 24, 2019

Journal/Publication:

The AAPS Journal

Publisher:

American Association of Pharmaceutical Scientists

Publication Date:

January 1, 2013

Issue:

Volume:

Pages:

195-218

URL:

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

Type:

Meta-analyses, Reviews, and Guidelines

Format:

Article

DOI (1):

10.1208/s12248-012-9432-8

Keywords

curcumin

curcuma

PMID (1):

23143785

MeSH

This is a fairly comprehensive review of the effects of curcumin on human health seen in clinical trials.

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Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways. Extensive clinical trials over the past quarter century have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in humans. Some promising effects have been observed in patients with various pro-inflammatory diseases including cancer, cardiovascular disease, arthritis, uveitis, ulcerative proctitis, Crohn's disease, ulcerative colitis, irritable bowel disease, tropical pancreatitis, peptic ulcer, gastric ulcer, idiopathic orbital inflammatory pseudotumor, oral lichen planus, gastric inflammation, vitiligo, psoriasis, acute coronary syndrome, atherosclerosis, diabetes, diabetic nephropathy, diabetic microangiopathy, lupus nephritis, renal conditions, acquired immunodeficiency syndrome, β-thalassemia, biliary dyskinesia, Dejerine-Sottas disease, cholecystitis, and chronic bacterial prostatitis. Curcumin has also shown protection against hepatic conditions, chronic arsenic exposure, and alcohol intoxication. Dose-escalating studies have indicated the safety of curcumin at doses as high as 12 g/day over 3 months. Curcumin's pleiotropic activities emanate from its ability to modulate numerous signaling molecules such as pro-inflammatory cytokines, apoptotic proteins, NF-κB, cyclooxygenase-2, 5-LOX, STAT3, C-reactive protein, prostaglandin E(2), prostate-specific antigen, adhesion molecules, phosphorylase kinase, transforming growth factor-β, triglyceride, ET-1, creatinine, HO-1, AST, and ALT in human participants. In clinical trials, curcumin has been used either alone or in combination with other agents. Various formulations of curcumin, including nanoparticles, liposomal encapsulation, emulsions, capsules, tablets, and powder, have been examined. In this review, we discuss in detail the various human diseases in which the effect of curcumin has been investigated.

Author/s:

Gupta, Subash C., Patchva, Sridevi, Aggarwal, Bharat B.

Turmeric Dosage: How Much Should You Take Per Day?

Tracy Ashby — Fri, 22 Feb 2019 06:00:00 +0000

Date Added:

February 22, 2019

Journal/Publication:

Healthline

Publisher:

Healthline Media

Publication Date:

June 11, 2018

URL:

Turmeric Dosage: How Much Should You Take Per Day?

Type:

Patient Education Materials

Format:

Article

Keywords

MeSH

A patient-friendly, evidence-based, referenced summary of the possible benefits and hazards of supplemental curcumin.

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You may know turmeric primarily as a spice, but it’s also used in Ayurvedic medicine, a holistic approach to health that originated in India over 3,000 years ago.

Turmeric supplements are now widely available for medicinal use, but knowing how much to take can be confusing.

Here’s a look at the uses and benefits of turmeric, effective doses and safety concerns.

Author/s:

Meixner, Makayla