Deprecated: Return type of DrupalCacheArray::offsetExists($offset) should either be compatible with ArrayAccess::offsetExists(mixed $offset): bool, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 362
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Deprecated: Return type of DrupalCacheArray::offsetSet($offset, $value) should either be compatible with ArrayAccess::offsetSet(mixed $offset, mixed $value): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 381
Deprecated: Return type of DrupalCacheArray::offsetUnset($offset) should either be compatible with ArrayAccess::offsetUnset(mixed $offset): void, or the #[\ReturnTypeWillChange] attribute should be used to temporarily suppress the notice in /home/rprlib/prod72/www/includes/bootstrap.inc on line 388 Adults Aged 80 years or older
https://www.rpr.lib.ok.us/taxonomy/term/12825/all
enStatin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study
https://www.rpr.lib.ok.us/resource/statin-therapy-primary-prevention-and-clinical-outcomes-adults-aged-80-and-older-1
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-09T00:00:00-05:00">March 9, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of the American Geriatrics Society</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Wiley Periodicals LLC</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-07T00:00:00-06:00">March 7, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.70375" target="_blank">Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even"> https://doi.org/10.1111/jgs.70375Digital Object Identifier (DOI) </div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/statin-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">statin therapy</a></div>
<div class="field-item odd"><a href="/tags/geriatrics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Geriatrics</a></div>
<div class="field-item even"><a href="/tags/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular disease</a></div>
<div class="field-item odd"><a href="/tags/adults-aged-80-years-or-older" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Adults Aged 80 years or older</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiovascular Disease</a></div>
<div class="field-item odd"><a href="/mesh/hydroxymethylglutaryl-coa-reductase-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hydroxymethylglutaryl-CoA Reductase Inhibitors</a></div>
<div class="field-item even"><a href="/mesh/follow-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">follow-up studies</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>RPR Commentary: Statins taken for primary prevention in adults over 80 were associated with a reduction in 4-year mortality rates of 31%. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-8d42095bafa60a1f1d3b93a5b3753dd8">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.70375" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older. Methods: We conducted a population-based retrospective cohort study using electronic medical records and pharmacy dispensing data from Clalit Health Services in Israel, covering the period from January 2015 to December 2020. Patients aged ≥ 80 years without prior CVD who were persistent statin users were compared with similar patients not receiving statins. Exclusions included prior CVD, dialysis, or death within 1 year of follow-up. Outcomes included all-cause mortality, new coronary events, myopathy, dementia, and diabetes mellitus. Cox proportional hazards models, adjusted for potential confounders, were used to assess the association between statin use and clinical outcomes. Results: Among 15,745 patients (mean age 84.5 years; 66% female), 8413 were statin users. Over a 4-year mean follow-up, statin use was associated with a 31% reduction in mortality (HR 0.69; 95% CI: 0.34–0.74; p < 0.001) and a 20% reduction in new coronary events (HR 0.80; 95% CI: 0.68–0.94; p = 0.008). No significant differences were observed in the incidence of myopathy, diabetes, or dementia. Benefits were not observed in patients who discontinued statins before age 80. Conclusions: In patients aged ≥ 80 years, statin therapy for primary prevention was associated with reduced all-cause mortality and coronary morbidity, without increased risk of adverse events. Early discontinuation diminished these benefits.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Wafaa Hamodi, Ophir Lavon, Samir Kassem</div>
</div>
</div>
Mon, 09 Mar 2026 21:11:08 +0000Nathan Hinkle2937 at https://www.rpr.lib.ok.usStatin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study
https://www.rpr.lib.ok.us/resource/statin-therapy-primary-prevention-and-clinical-outcomes-adults-aged-80-and-older-0
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-09T00:00:00-05:00">March 9, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of the American Geriatrics Society</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Wiley Periodicals LLC</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-07T00:00:00-06:00">March 7, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.70375" target="_blank">Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even"> https://doi.org/10.1111/jgs.70375Digital Object Identifier (DOI) </div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/statin-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">statin therapy</a></div>
<div class="field-item odd"><a href="/tags/geriatrics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Geriatrics</a></div>
<div class="field-item even"><a href="/tags/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular disease</a></div>
<div class="field-item odd"><a href="/tags/adults-aged-80-years-or-older" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Adults Aged 80 years or older</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiovascular Disease</a></div>
<div class="field-item odd"><a href="/mesh/hydroxymethylglutaryl-coa-reductase-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hydroxymethylglutaryl-CoA Reductase Inhibitors</a></div>
<div class="field-item even"><a href="/mesh/follow-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">follow-up studies</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>RPR Commentary: Statins taken for primary prevention in adults over 80 were associated with a reduction in 4-year mortality rates of 31%. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-f9332e0b59b52f993a80cd75c9707a72">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.70375" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older. Methods: We conducted a population-based retrospective cohort study using electronic medical records and pharmacy dispensing data from Clalit Health Services in Israel, covering the period from January 2015 to December 2020. Patients aged ≥ 80 years without prior CVD who were persistent statin users were compared with similar patients not receiving statins. Exclusions included prior CVD, dialysis, or death within 1 year of follow-up. Outcomes included all-cause mortality, new coronary events, myopathy, dementia, and diabetes mellitus. Cox proportional hazards models, adjusted for potential confounders, were used to assess the association between statin use and clinical outcomes. Results: Among 15,745 patients (mean age 84.5 years; 66% female), 8413 were statin users. Over a 4-year mean follow-up, statin use was associated with a 31% reduction in mortality (HR 0.69; 95% CI: 0.34–0.74; p < 0.001) and a 20% reduction in new coronary events (HR 0.80; 95% CI: 0.68–0.94; p = 0.008). No significant differences were observed in the incidence of myopathy, diabetes, or dementia. Benefits were not observed in patients who discontinued statins before age 80. Conclusions: In patients aged ≥ 80 years, statin therapy for primary prevention was associated with reduced all-cause mortality and coronary morbidity, without increased risk of adverse events. Early discontinuation diminished these benefits.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Wafaa Hamodi, Ophir Lavon, Samir Kassem</div>
</div>
</div>
Mon, 09 Mar 2026 21:10:43 +0000Nathan Hinkle2935 at https://www.rpr.lib.ok.usStatin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study
https://www.rpr.lib.ok.us/resource/statin-therapy-primary-prevention-and-clinical-outcomes-adults-aged-80-and-older
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-09T00:00:00-05:00">March 9, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
<div class="field-items">
<div class="field-item even">Journal of the American Geriatrics Society</div>
</div>
</div>
<div class="field field-name-field-artifact-publisher field-type-text field-label-inline clearfix">
<div class="field-label">Publisher: </div>
<div class="field-items">
<div class="field-item even">Wiley Periodicals LLC</div>
</div>
</div>
<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
<div class="field-items">
<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-03-07T00:00:00-06:00">March 7, 2026</span></div>
</div>
</div>
<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
<div class="field-items">
<div class="field-item even"><a href="https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.70375" target="_blank">Statin Therapy for Primary Prevention and Clinical Outcomes in Adults Aged 80 and Older: A Retrospective Comparative Cohort Study</a></div>
</div>
</div>
<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Clinical Research Results</div>
</div>
</div>
<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
<div class="field-items">
<div class="field-item even">Article</div>
</div>
</div>
<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
<div class="field-items">
<div class="field-item even"> https://doi.org/10.1111/jgs.70375Digital Object Identifier (DOI) </div>
</div>
</div>
<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
<div class="field-items">
<div class="field-item even"><a href="/tags/statin-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">statin therapy</a></div>
<div class="field-item odd"><a href="/tags/geriatrics" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Geriatrics</a></div>
<div class="field-item even"><a href="/tags/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular disease</a></div>
<div class="field-item odd"><a href="/tags/adults-aged-80-years-or-older" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Adults Aged 80 years or older</a></div>
</div>
</div>
<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/cardiovascular-disease" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cardiovascular Disease</a></div>
<div class="field-item odd"><a href="/mesh/hydroxymethylglutaryl-coa-reductase-inhibitors" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hydroxymethylglutaryl-CoA Reductase Inhibitors</a></div>
<div class="field-item even"><a href="/mesh/follow-studies" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">follow-up studies</a></div>
</div>
</div>
<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>RPR Commentary: Statins taken for primary prevention in adults over 80 were associated with a reduction in 4-year mortality rates of 31%. James W. Mold, MD, MPH</p>
</div>
</div>
</div>
<div class="field field-name-field-artifact-text-availability field-type-list-text field-label-hidden">
<div class="field-items">
<div class="field-item even">Free full text</div>
</div>
</div>
<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
<div class="field-items">
<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-15acd32f97f0d9610a62c3a5dd29949e">
<div class="view-content">
<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.70375" class="btn btn-primary" target="_blank">View</a> </div>
</div>
</div></div>
</div>
</div>
<div class="field field-name-body field-type-text-with-summary field-label-hidden">
<div class="field-items">
<div class="field-item even" property="content:encoded"><p>ABSTRACT Background: Evidence supporting the use of statins for primary prevention of cardiovascular disease (CVD) in individuals aged≥ 80 years remains limited. This study aimed to evaluate the long-term clinical benefits and safety of statins for primary prevention in patients aged 80 years and older. Methods: We conducted a population-based retrospective cohort study using electronic medical records and pharmacy dispensing data from Clalit Health Services in Israel, covering the period from January 2015 to December 2020. Patients aged ≥ 80 years without prior CVD who were persistent statin users were compared with similar patients not receiving statins. Exclusions included prior CVD, dialysis, or death within 1 year of follow-up. Outcomes included all-cause mortality, new coronary events, myopathy, dementia, and diabetes mellitus. Cox proportional hazards models, adjusted for potential confounders, were used to assess the association between statin use and clinical outcomes. Results: Among 15,745 patients (mean age 84.5 years; 66% female), 8413 were statin users. Over a 4-year mean follow-up, statin use was associated with a 31% reduction in mortality (HR 0.69; 95% CI: 0.34–0.74; p < 0.001) and a 20% reduction in new coronary events (HR 0.80; 95% CI: 0.68–0.94; p = 0.008). No significant differences were observed in the incidence of myopathy, diabetes, or dementia. Benefits were not observed in patients who discontinued statins before age 80. Conclusions: In patients aged ≥ 80 years, statin therapy for primary prevention was associated with reduced all-cause mortality and coronary morbidity, without increased risk of adverse events. Early discontinuation diminished these benefits.</p>
</div>
</div>
</div>
<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Wafaa Hamodi, Ophir Lavon, Samir Kassem</div>
</div>
</div>
Mon, 09 Mar 2026 21:10:39 +0000Nathan Hinkle2933 at https://www.rpr.lib.ok.us