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https://www.rpr.lib.ok.us/taxonomy/term/12638/all en https://www.rpr.lib.ok.us/resource/association-between-medication-use-and-vitamin-b12-deficiency-elderly-population-cross <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-02-09T00:00:00-06:00">February 9, 2026</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">BMC Geriatrics</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-02-03T00:00:00-06:00">February 3, 2026</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/41634610/" target="_blank">The association between medication use and vitamin B12 deficiency in the elderly population: a cross- sectional study</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1186/s12877-026-07040-6</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/metformin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">metformin</a></div> <div class="field-item odd"><a href="/tags/metformin-treatment" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Metformin Treatment</a></div> <div class="field-item even"><a href="/tags/anticonvulsants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">anticonvulsants</a></div> <div class="field-item odd"><a href="/tags/antacids" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antacids</a></div> <div class="field-item even"><a href="/tags/vitamin-b-12-deficiency" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Vitamin B 12 Deficiency</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">41634610</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/hypoglycemic-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hypoglycemic agents</a></div> <div class="field-item odd"><a href="/mesh/metformin" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Metformin</a></div> <div class="field-item even"><a href="/mesh/vitamin-b-12" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Vitamin B 12</a></div> <div class="field-item odd"><a href="/mesh/lipids" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Lipids</a></div> <div class="field-item even"><a href="/mesh/anticonvulsants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Anticonvulsants</a></div> <div class="field-item odd"><a href="/mesh/antacids" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Antacids</a></div> <div class="field-item even"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div> <div class="field-item odd"><a href="/mesh/adult" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Adult</a></div> <div class="field-item even"><a href="/mesh/aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">aged</a></div> <div class="field-item odd"><a href="/mesh/infant" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">infant</a></div> <div class="field-item even"><a href="/mesh/dietary-supplements" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">dietary supplements</a></div> <div class="field-item odd"><a href="/mesh/hypoglycemic-agents" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hypoglycemic agents</a></div> <div class="field-item even"><a href="/mesh/vitamin-b-12-deficiency" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Vitamin B 12 Deficiency</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>Perhaps patients who are taking metformin should be routinely put on oral B12 and then monitored, James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-2a806461e4b4fc3c232ba5a6a287ec78"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://pubmed.ncbi.nlm.nih.gov/41634610/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Background<br /> Vitamin B12 deficiency is common in the elderly population and can cause severe complications. The use of certain medication has in previous studies been associated with vitamin B12 deficiency in the general population. To identify elderly patients at risk for vitamin B12 deficiency due to medication use, we evaluated the association between medication use and vitamin B12 deficiency in the elderly population.</p> <p>Methods<br /> Hospitalized geriatric patients 65 years of age or over with a serum vitamin B12 measurement within one week of the admittance date were included. Patients were classified as either B12 normal (258–635 pmol/L) or B12 deficient (&lt; 148 pmol/L). Upon hospital admission patients’ medication use was verified. The association between vitamin B12 deficiency and the use of antacid, antiepileptic, antidiabetic, lipid lowering and other medication was evaluated by univariate and multivariate analyses.</p> <p>Results<br /> Of the 7132 patients included in the study, 532 (7.5%) had vitamin B12 deficiency and 3433 (48.1%) patients had normal vitamin B12 concentrations. Metformin use was significantly and independently (adjusted OR 2.5; 95% CI 1.7–3.6) associated with a dose-dependent higher risk of vitamin B12 deficiency. The use of other medication evaluated in this study was not associated with vitamin B12 deficiency.</p> <p>Conclusions<br /> Metformin use is significantly associated with vitamin B12 deficiency in the elderly, and this risk rises with higher metformin doses. Monitoring and timely start of vitamin B12 supplementation along with the lowest possible metformin dose are essential to prevent complications.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Monique P H Tillemans, Thijs J Giezen, Toine C G Egberts, Kees J Kalisvaart</div> </div> </div> Mon, 09 Feb 2026 16:51:18 +0000 Megan George 2893 at https://www.rpr.lib.ok.us