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https://www.rpr.lib.ok.us/taxonomy/term/12607/all en https://www.rpr.lib.ok.us/resource/exacerbation-risk-patients-bronchiectasis-receiving-dpp-1-inhibitors-vs-placebo-meta <div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Date Added:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-02-03T00:00:00-06:00">February 3, 2026</span></div> </div> </div> <div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix"> <div class="field-label">Journal/Publication:&nbsp;</div> <div class="field-items"> <div class="field-item even">Respiratory Medicine</div> </div> </div> <div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix"> <div class="field-label">Publication Date:&nbsp;</div> <div class="field-items"> <div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2026-01-31T00:00:00-06:00">January 31, 2026</span></div> </div> </div> <div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix"> <div class="field-label">URL:&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/41443427/" target="_blank">Exacerbation risk in patients with bronchiectasis receiving DPP-1 inhibitors vs placebo: A meta-analysis of RCTs</a></div> </div> </div> <div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Type:&nbsp;</div> <div class="field-items"> <div class="field-item even">Clinical Research Results</div> </div> </div> <div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Format:&nbsp;</div> <div class="field-items"> <div class="field-item even">Article</div> </div> </div> <div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix"> <div class="field-label">DOI (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">10.1016/j.rmed.2025.108607</div> </div> </div> <div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above"> <div class="field-label">Keywords&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/tags/bronchiectasis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Bronchiectasis</a></div> <div class="field-item odd"><a href="/tags/dpp-1-inhibitor" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">DPP-1 inhibitor</a></div> <div class="field-item even"><a href="/tags/dipeptidyl-peptidases-and-tripeptidyl-peptidases" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dipeptidyl-peptidases and tripeptidyl-peptidases</a></div> <div class="field-item odd"><a href="/tags/meta-analysis" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">meta-analysis</a></div> </div> </div> <div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix"> <div class="field-label">PMID (1):&nbsp;</div> <div class="field-items"> <div class="field-item even">41443427</div> </div> </div> <div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above"> <div class="field-label">MeSH&nbsp;</div> <div class="field-items"> <div class="field-item even"><a href="/mesh/bronchiectasis-drug-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Bronchiectasis* / drug therapy</a></div> <div class="field-item odd"><a href="/mesh/bronchiectasis-physiopathology" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Bronchiectasis* / physiopathology</a></div> <div class="field-item even"><a href="/mesh/dipeptidyl-peptidase-iv-inhibitors-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Dipeptidyl-Peptidase IV Inhibitors* / therapeutic use</a></div> <div class="field-item odd"><a href="/mesh/disease-progression" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Disease Progression</a></div> <div class="field-item even"><a href="/mesh/forced-expiratory-volume-drug-effects" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Forced Expiratory Volume / drug effects</a></div> <div class="field-item odd"><a href="/mesh/randomized-controlled-trials-topic" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Randomized Controlled Trials as Topic</a></div> <div class="field-item even"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div> <div class="field-item odd"><a href="/mesh/male" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">male</a></div> <div class="field-item even"><a href="/mesh/adult" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Adult</a></div> <div class="field-item odd"><a href="/mesh/female" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">female</a></div> </div> </div> <div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden"> <div class="field-items"> <div class="field-item even"><p>GLP-1 inhibitors appear to benefit patients with bronchiectasis apart from their weight reduction effect. James W. Mold, MD, MPH</p> </div> </div> </div> <div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden"> <div class="field-items"> <div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-3d509892406b15c7a3b24e0816dab55d"> <div class="view-content"> <div class="views-row views-row-1 views-row-odd views-row-first views-row-last"> <a href="https://pubmed.ncbi.nlm.nih.gov/41443427/" class="btn btn-primary" target="_blank">View</a> </div> </div> </div></div> </div> </div> <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <div class="field-items"> <div class="field-item even" property="content:encoded"><p>Background: No therapies have been approved to alter bronchiectasis progression. Dipeptidyl peptidase-1 (DPP-1) inhibitors, which target neutrophil serine protease activation, are under investigation as potential disease-modifying agents.</p> <p>Methods: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing DPP-1 inhibitors versus placebo in patients with non-cystic fibrosis bronchiectasis. PubMed, Cochrane, EMBASE, Web of Science, Scopus, ClinicalTrials.gov, and ICTRP were searched from inception until April 26, 2025. Primary outcomes included time to first exacerbation and proportion of patients remaining exacerbation-free. Secondary outcomes included post-bronchodilator % Forced Expiratory Volume in 1 s (FEV1), Quality of Life-Bronchiectasis (QoL-B) questionnaire scores, and rate of adverse events. Time-to-event outcome was analyzed using Kaplan-Meier (KM)-estimated individual patient data (IPD), whereas random-effects meta-analyses were performed for remaining outcomes.</p> <p>Results: 2523 patients from four RCTs were included, of whom 1689 (66.9 %) received DPP-1 inhibitors. Compared with placebo, DPP-1 inhibitors prolonged the time to first exacerbation (HR 0.79; 95 % CI: 0.71 to 0.88) and increased the proportion of patients remaining exacerbation-free (RR 1.33; 95 % CI 1.12 to 1.58). A slower decline in post-bronchodilator % FEV1 was observed (MD 1.1 %; 95 % CI 0.05 to 2.15), but no difference in QoL-B scores (MD 1.35; 95 % CI -0.72 to 3.42). The safety profile of DPP-1 inhibitors was acceptable and comparable to placebo. Moderate certainty was found across endpoints.</p> <p>Conclusions: DPP-1 inhibitors prolong time to first exacerbation and reduce exacerbation rates in patients with bronchiectasis, with an acceptable safety profile. These findings support their potential as a disease-modifying strategy.</p> <p>Registration: PROSPERO (CRD420251042542).</p> <p>Keywords: Bronchiectasis; DPP-1 inhibitor; Dipeptidyl-peptidases and tripeptidyl-peptidases; Meta-analysis; Randomized controlled trials; Systematic review.</p> </div> </div> </div> <div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix"> <div class="field-label">Author/s:&nbsp;</div> <div class="field-items"> <div class="field-item even">Giulia Carvalhal, Júlia Moreira Diniz, Larissa Calixto Hespanhol, David Curi Barbosa Izoton Cabral, Jafar Aljazeeri</div> </div> </div> Tue, 03 Feb 2026 14:17:01 +0000 Megan George 2887 at https://www.rpr.lib.ok.us