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https://www.rpr.lib.ok.us/taxonomy/term/12025/all
enTestosterone Treatment in Middle-Aged and Older Men with Hypogonadism
https://www.rpr.lib.ok.us/resource/testosterone-treatment-middle-aged-and-older-men-hypogonadism
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-09-02T00:00:00-05:00">September 2, 2025</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">The New England Journal of Medicine</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2025-08-06T00:00:00-05:00">August 6, 2025</span></div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/40768717/" target="_blank">Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
<div class="field-items">
<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1056/NEJMra2404637</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/testosterone" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">testosterone</a></div>
<div class="field-item odd"><a href="/tags/hypogonadism" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">hypogonadism</a></div>
<div class="field-item even"><a href="/tags/libido" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Libido</a></div>
<div class="field-item odd"><a href="/tags/anemia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">anemia</a></div>
<div class="field-item even"><a href="/tags/pulmonary-embolism" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pulmonary embolism</a></div>
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</div>
<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">40768717</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
<div class="field-items">
<div class="field-item even"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div>
<div class="field-item odd"><a href="/mesh/male" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">male</a></div>
<div class="field-item even"><a href="/mesh/middle-aged" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Middle Aged</a></div>
<div class="field-item odd"><a href="/mesh/testosterone" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Testosterone</a></div>
<div class="field-item even"><a href="/mesh/prediabetic-state" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Prediabetic State</a></div>
<div class="field-item odd"><a href="/mesh/glycemic-control" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Glycemic control</a></div>
<div class="field-item even"><a href="/mesh/libido" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Libido</a></div>
<div class="field-item odd"><a href="/mesh/cardiovascular-diseases" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">cardiovascular diseases</a></div>
<div class="field-item even"><a href="/mesh/urinary-retention" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Urinary Retention</a></div>
<div class="field-item odd"><a href="/mesh/hypogonadism" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Hypogonadism</a></div>
<div class="field-item even"><a href="/mesh/prostatic-neoplasms" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">prostatic neoplasms</a></div>
<div class="field-item odd"><a href="/mesh/cognitive-dysfunction-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Cognitive Dysfunction* / therapy</a></div>
<div class="field-item even"><a href="/mesh/pulmonary-embolism" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">pulmonary embolism</a></div>
<div class="field-item odd"><a href="/mesh/lower-urinary-tract-symptoms" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Lower Urinary Tract Symptoms</a></div>
<div class="field-item even"><a href="/mesh/anemia" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Anemia</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
<div class="field-items">
<div class="field-item even"><p>A review of testosterone replacement in middle-aged and older men with hypogonadism. James W. Mold, MD, MPH</p>
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<div class="field field-name-field-artifact-document-content field-type-entityreference field-label-hidden">
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<div class="field-item even"><div class="view view-artifact-docs view-id-artifact_docs view-display-id-block view-dom-id-9506c719d60b8e28ce854db63e3cad3d">
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<div class="views-row views-row-1 views-row-odd views-row-first views-row-last">
<a href="https://pubmed.ncbi.nlm.nih.gov/40768717/" class="btn btn-primary" target="_blank">View</a> </div>
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</div></div>
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<div class="field field-name-body field-type-text-with-summary field-label-hidden">
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<div class="field-item even" property="content:encoded"><p>•<br />
In clinical trials involving middle-aged and older men with hypogonadism, testosterone treatment led to improved sexual activity and libido, correction of anemia, and modestly improved energy, mood, and walking ability. (The following key points also refer to findings from clinical trials involving this patient population.)<br />
•<br />
Testosterone treatment did not improve cognition in men without a previously diagnosed cognitive disorder and did not prevent progression to diabetes in men with prediabetes or improve glycemic control in those with diabetes.<br />
•<br />
Testosterone treatment did not increase the risk of major cardiovascular events among men with preexisting cardiovascular disease.<br />
•<br />
Testosterone treatment did not increase the risk of prostate cancer or acute urinary retention and did not worsen lower urinary tract symptoms.<br />
•<br />
Testosterone treatment was associated with an increased risk of clinical fractures and pulmonary embolism.<br />
•<br />
The decision to administer testosterone treatment in a man with hypogonadism should be based on the severity of the hypogonadism and an assessment of the potential benefits and risks of treatment.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
<div class="field-items">
<div class="field-item even">Shalender Bhasin, Peter J Snyder</div>
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Tue, 02 Sep 2025 13:52:11 +0000Megan George2747 at https://www.rpr.lib.ok.us