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https://www.rpr.lib.ok.us/taxonomy/term/10950/all
enLong-Term Use of Muscle Relaxant Medications for Chronic Pain: A Systematic Review
https://www.rpr.lib.ok.us/resource/long-term-use-muscle-relaxant-medications-chronic-pain-systematic-review
<div class="field field-name-field-artifact-uploaded-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Date Added: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-09-25T00:00:00-05:00">September 25, 2024</span></div>
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<div class="field field-name-field-artifact-journal field-type-text field-label-inline clearfix">
<div class="field-label">Journal/Publication: </div>
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<div class="field-item even">JAMA Network Open</div>
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<div class="field field-name-field-artifact-published-date field-type-datetime field-label-inline clearfix">
<div class="field-label">Publication Date: </div>
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<div class="field-item even"><span class="date-display-single" property="dc:date" datatype="xsd:dateTime" content="2024-09-19T00:00:00-05:00">September 19, 2024</span></div>
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<div class="field field-name-field-artifact-issue field-type-text field-label-inline clearfix">
<div class="field-label">Issue: </div>
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<div class="field-item even">9</div>
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<div class="field field-name-field-artifact-volume field-type-text field-label-inline clearfix">
<div class="field-label">Volume: </div>
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<div class="field-item even">7</div>
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<div class="field field-name-field-artifact-url field-type-link-field field-label-inline clearfix">
<div class="field-label">URL: </div>
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<div class="field-item even"><a href="https://pubmed.ncbi.nlm.nih.gov/39298168/" target="_blank">Long-Term Use of Muscle Relaxant Medications for Chronic Pain: A Systematic Review</a></div>
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<div class="field field-name-field-artifact-type field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Type: </div>
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<div class="field-item even">Meta-analyses, Reviews, and Guidelines</div>
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<div class="field field-name-field-artifact-format field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Format: </div>
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<div class="field-item even">Article</div>
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<div class="field field-name-field-artifact-doi-1 field-type-text field-label-inline clearfix">
<div class="field-label">DOI (1): </div>
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<div class="field-item even">10.1001/jamanetworkopen.2024.34835</div>
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<div class="field field-name-field-artifact-keywords field-type-taxonomy-term-reference field-label-above">
<div class="field-label">Keywords </div>
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<div class="field-item even"><a href="/tags/chronic-pain" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">chronic pain</a></div>
<div class="field-item odd"><a href="/tags/muscle-relaxants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">muscle relaxants</a></div>
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<div class="field field-name-field-artifact-pmid-1 field-type-text field-label-inline clearfix">
<div class="field-label">PMID (1): </div>
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<div class="field-item even">39298168</div>
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<div class="field field-name-field-artifact-mesh field-type-taxonomy-term-reference field-label-above">
<div class="field-label">MeSH </div>
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<div class="field-item even"><a href="/mesh/chronic-pain-therapy" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Chronic Pain* / therapy</a></div>
<div class="field-item odd"><a href="/mesh/muscle-relaxants" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Muscle Relaxants</a></div>
<div class="field-item even"><a href="/mesh/central-therapeutic-use" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Central / therapeutic use</a></div>
<div class="field-item odd"><a href="/mesh/humans" typeof="skos:Concept" property="rdfs:label skos:prefLabel" datatype="">Humans</a></div>
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<div class="field field-name-field-artifact-editor-note field-type-text-long field-label-hidden">
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<div class="field-item even"><p>Aside from a few specific indications, muscle relaxants do not benefit patients with chronic pain. James W. Mold, MD, MPH</p>
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<div class="field-item even">Free full text</div>
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<a href="https://pubmed.ncbi.nlm.nih.gov/39298168/" class="btn btn-primary" target="_blank">View</a> </div>
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<div class="field field-name-body field-type-text-with-summary field-label-hidden">
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<div class="field-item even" property="content:encoded"><p>Importance: Stricter opioid prescribing guidelines have increased prescriptions of skeletal muscle relaxants (SMRs) for chronic pain, but the efficacy of long-term use of SMRs for chronic pain is unknown.</p>
<p>Objective: To systematically review the effectiveness or efficacy of long-term use of SMRs for chronic pain.</p>
<p>Evidence review: Two reviewers systematically searched Ovid MEDLINE, Embase (Ovid), Web of Science, CINAHL, and Cochrane through December 4, 2023. They included articles published in English, Spanish, or Italian. Only randomized clinical trials (RCTs) and cohort studies with comparator groups evaluating at least 1-month duration of SMRs for chronic pain were included. The reviewers dually reviewed data abstraction, risk-of-bias, and quality. They characterized studies by chronic pain syndrome: low back pain, fibromyalgia, headaches, painful cramps or spasticity, and other syndromes.</p>
<p>Findings: A total of 30 RCTs with 1314 participants and 14 cohort studies with 1168 participants assessed SMRs for chronic pain. Studies were primarily short-term (4-6 weeks). Nine unique SMRs were represented by the studies identified. Eleven studies (25%) examined baclofen, 8 (18%) examined tizanidine, and 7 (16%) examined cyclobenzaprine. Evidence for effectiveness was strongest for SMRs used for trigeminal neuralgia, neck pain, and painful cramps; evidence suggested SMRs for fibromyalgia, low back pain, and other syndromes were not more beneficial than placebo. The most common adverse effects were sedation and dry mouth. RCTs had a low to moderate risk of bias, and the quality of cohort studies was fair to good.</p>
<p>Conclusions and relevance: In this systematic review of long-term use of SMRs for chronic pain, findings suggest that their long-term use may benefit patients with painful spasms or cramps and neck pain; their long-term use for low back pain, fibromyalgia, and headaches did not appear to be beneficial. Clinicians should be vigilant for adverse effects and consider deprescribing if pain-related goals are not met.</p>
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<div class="field field-name-field-resource-author field-type-taxonomy-term-reference field-label-inline clearfix">
<div class="field-label">Author/s: </div>
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<div class="field-item even">Benjamin J Oldfield, Brynna Gleeson, Kenneth L Morford, Zoe Adams, Melissa C Funaro, William C Becker, Jessica S Merlin</div>
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Wed, 25 Sep 2024 13:18:36 +0000Alex Haga2427 at https://www.rpr.lib.ok.us