What Is Narcolepsy?

Author/s: 
Sum-Ping, O., Mignot, E.
Date Added: 
May 10, 2023
Journal/Publication: 
JAMA
Publisher: 
American Medical Association
Publication Date: 
May 5, 2023
Type: 
Patient Education Materials
Format: 
Article
DOI (1): 
10.1001/jama.2023.5149
PMID (1): 
37145499

RPR Commentary

Illustrated information on narcolepsy for patients. James W. Mold, MD, MPH

Abstract

Narcolepsy is a chronic disorder that causes excessive daytime sleepiness
and other symptoms that are due to abnormal rapid eye movement (REM) sleep.
Other signs and symptoms:
• Quick transitions into REM sleep
• Vivid dreams, hallucinations, and sleep paralysis
• Cataplexy (sudden, short periods of muscle weakness triggered
by strong emotions, typically laughter) in narcolepsy type 1
Narcolepsy type 1 occurs when the hypothalamus produces little or no orexin,
a hormone that helps maintain wakefulness and controls REM (dreaming) sleep.
Narcolepsy type 2 does not have a known cause.

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