What Is Hypothyroidism?

Author/s: 
Krista Roberts
Date Added: 
December 12, 2025
Journal/Publication: 
JAMA
Publication Date: 
December 11, 2025
Type: 
Patient Education Materials
DOI (1): 
10.1001/jama.2025.19536

RPR Commentary

Information for patients about hypothyroidism. James W. Mold, MD, MPH

Abstract

Hypothyroidism is a disease of thyroid hormone deficiency.

The most common cause of hypothyroidism worldwide is insufficient intake of iodine, a mineral found in iodized salt and some foods (such as seafood and dairy) that is needed for production of thyroid hormones. In the US and other high-income countries, the most common cause of hypothyroidism is an autoimmune condition called Hashimoto thyroiditis.1